Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing

• Published in: Developmental cell Vol. 53; no. 1; pp. 102 - 116.e8
• Main Authors: Cui, Miao, Wang, Zhaoning, Chen, Kenian, Shah, Akansha M., Tan, Wei, Duan, Lauren, Sanchez-Ortiz, Efrain, Li, Hui, Xu, Lin, Liu, Ning, Bassel-Duby, Rhonda, Olson, Eric N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.04.2020
• Subjects: Animals; Animals, Newborn; Cell Cycle - physiology; Cell Proliferation - physiology; cell survival; Gene Expression Regulation, Developmental - genetics; Heart - physiology; heart regeneration; ischemia; Myocardial Infarction - metabolism; Myocytes, Cardiac - cytology; NFE2L1; NFYa; Regeneration - physiology; Transcription Factors - metabolism; transcriptional response to injury; transcriptional response to injury; cell survival; heart regeneration; NFYa; NFE2L1; ischemia

The adult mammalian heart is incapable of regeneration following injury. In contrast, the neonatal mouse heart can efficiently regenerate during the first week of life. The molecular mechanisms that mediate the regenerative response and its blockade in later life are not understood. Here, by single-...