A randomized, placebo‐controlled, dose‐escalation phase I/II multicenter trial of low‐dose cidofovir for BK polyomavirus nephropathy - Imlay, Hannah; Gnann, John W.; Rooney, James; Peddi, V. Ram; Wiseman, Alexander C.; Josephson, Michelle A.; Kew, Clifton; Young, Jo‐Anne H.; Adey, Deborah B.; Samaniego‐Picota, Milagros; Whitley, Richard J.; Limaye, Ajit P. (Transplant infectious disease, 2024)
Keywords: Adult; Aged; Allografts; Antiviral Agents - administration & dosage; Antiviral Agents - adverse effects; Antiviral Agents - therapeutic use; Antiviral drugs; Biopsy; BK virus; BK Virus - physiology; Case reports; Cidofovir; Cidofovir - administration & dosage; Cidofovir - therapeutic use; Cytosine - administration & dosage; Cytosine - adverse effects; Cytosine - analogs & derivatives; Cytosine - therapeutic use; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glomerular filtration rate; Glomerular Filtration Rate - drug effects; Humans; In vitro methods and tests; Kidney Diseases - virology; kidney transplant; Kidney transplantation; Kidney Transplantation - adverse effects; Male; Middle Aged; Nephropathy; Organophosphonates - administration & dosage; Organophosphonates - adverse effects; Organophosphonates - therapeutic use; Original; Placebos; Polyomavirus Infections - drug therapy; Polyomavirus Infections - virology; randomized controlled trial; Renal failure; Treatment Outcome; Tumor Virus Infections - drug therapy; Tumor Virus Infections - virology; cidofovir; kidney transplant; BK virus; randomized controlled trial