A High-Sensitivity and Low-Power Theranostic Nanosystem for Cell SERS Imaging and Selectively Photothermal Therapy Using Anti-EGFR-Conjugated Reduced Graphene Oxide/Mesoporous Silica/AuNPs Nanosheets

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 12; no. 11; pp. 1458 - 1468
• Main Authors: Chen, Yu-Wei, Liu, Ting-Yu, Chen, Po-Jung, Chang, Po-Hsueh, Chen, San-Yuan
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.03.2016; Wiley Subscription Services, Inc
• Subjects: A549 Cells; Carbon; Cell Survival; cell targeting; cell tracking; Gold - chemistry; Graphene; Graphite - chemistry; Humans; Hyperthermia, Induced; Lasers; Microscopy, Fluorescence; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Nanostructure; Nanotechnology; Oxidation-Reduction; Oxides; Phototherapy; photothermal therapy; Porosity; Raman scattering; Receptor, Epidermal Growth Factor - metabolism; Self assembly; Silicon dioxide; Silicon Dioxide - chemistry; Spectrum Analysis, Raman - methods; surface-enhanced raman scattering; Theranostic Nanomedicine - methods; theranostics; Therapy; surface-enhanced raman scattering; theranostics; cell tracking; cell targeting; photothermal therapy

A high‐sensitivity and low‐power theranostic nanosystem that combines with synergistic photothermal therapy and surface‐enhanced Raman scattering (SERS) mapping is constructed by mesoporous silica self‐assembly on the reduced graphene oxide (rGO) nanosheets with nanogap‐aligned gold nanoparticles (A...