γ‐Tocopherol‐enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice

• Published in: International journal of cancer Vol. 124; no. 7; pp. 1693 - 1699
• Main Authors: Barve, Avantika, Khor, Tin Oo, Nair, Sujit, Reuhl, Kenneth, Suh, Nanjoo, Reddy, Bandaru, Newmark, Harold, Kong, Ah‐Ng
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2009
• Subjects: Animals; antioxidant detoxifying enzymes; Antioxidants - metabolism; Antioxidants - pharmacology; Blotting, Western; Diet; Disease Models, Animal; gamma-Tocopherol - therapeutic use; Immunohistochemistry; Male; Metabolic Detoxication, Phase II; Mice; NF-E2-Related Factor 2 - metabolism; Nrf2; oxidative stress; Oxidoreductases - metabolism; prostate cancer; Prostatic Neoplasms - diet therapy; Prostatic Neoplasms - prevention & control; Reverse Transcriptase Polymerase Chain Reaction; RNA - analysis; Tocopherols - therapeutic use

γ‐tocopherol (γ‐T) alone or in combination with α‐tocopherol has been shown to suppress biomarkers of oxidative stress in asthamatics and human subjects with metabolic syndrome. Oxidative stress has been implicated as a key event in prostate carcinogenesis. Hence, the purpose of this study was to ex...