Correlation of striatal dopamine D2/3 receptor availability with GABA level in the anterior cingulate cortex in healthy controls but not in alcohol‐dependent subjects and individuals at high risk: A multimodal magnetic resonance spectroscopy and positron emission tomography study

• Published in: Addiction biology Vol. 29; no. 6; pp. e13424 - n/a
• Main Authors: Spitta, Gianna, Gleich, Tobias, Rosenthal, Annika, Schubert, Florian, Aydin, Semiha, Heinz, Andreas, Buchert, Ralph, Gallinat, Jürgen
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2024; John Wiley and Sons Inc
• Subjects: Addictions; Adult; Alcohol; alcohol dependence; Alcoholism - diagnostic imaging; Alcoholism - metabolism; Benzamides; Case-Control Studies; Corpus Striatum - diagnostic imaging; Corpus Striatum - metabolism; Cortex (cingulate); Dopamine; Dopamine D2 receptors; dopamine D2/3 receptor; Drug dependence; Female; GABA; gamma-Aminobutyric Acid - metabolism; Glutamic Acid - metabolism; Gyrus Cinguli - diagnostic imaging; Gyrus Cinguli - metabolism; Humans; individuals at high risk; Magnetic Resonance Spectroscopy; Male; Mesolimbic system; Middle Aged; Neostriatum; Neurotransmission; Original; Positron emission tomography; Receptors, Dopamine D2 - metabolism; Receptors, Dopamine D3 - metabolism; Spectrum analysis; Tomography; γ-Aminobutyric acid; GABA; dopamine D2/3 receptor; magnetic resonance spectroscopy; positron emission tomography; alcohol dependence; individuals at high risk

Background The association of impaired dopaminergic neurotransmission with the development and maintenance of alcohol use disorder is well known. More specifically, reduced dopamine D2/3 receptors in the striatum of subjects with alcohol dependence (AD) compared to healthy controls have been found i...