Addressing subject heterogeneity in time‐dependent discrimination for biomarker evaluation

• Published in: Statistics in medicine Vol. 43; no. 7; pp. 1341 - 1353
• Main Authors: Jiang, Xinyang, Li, Wen, Li, Ruosha, Ning, Jing
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 30.03.2024; Wiley Subscription Services, Inc
• Subjects: Area Under Curve; Biomarkers; Computer Simulation; covariate‐specific time‐dependent AUC; Demographics; Humans; Medical prognosis; Predictive analytics; predictive discrimination; Probability; prognostic biomarker; pseudo partial‐likelihood; ROC Curve; Time Factors; predictive discrimination; prognostic biomarker; pseudo partial-likelihood; covariate-specific time-dependent AUC

Accurate discrimination has been the central goal in identifying biomarkers for monitoring disease progression and early detection. Acknowledging the fact that discrimination accuracy of biomarkers for a time‐to‐event outcome often changes over time, local measures such as the time‐dependent receive...