Evaluation of the Pharmacokinetic Drug Interaction of Capmatinib With Itraconazole and Rifampicin and Potential Impact on Renal Transporters in Healthy Subjects - Cui, Xiaoming; Chen, Xinhui; Pognan, Nathalie; Sengupta, Tirtha; Rahmanzadeh, Gholamreza; Kornberger, Ruediger; Giovannini, Monica (Journal of clinical pharmacology, 2023)
Keywords: Area Under Curve; capmatinib; Creatinine; CYP3A; Cystatin C; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 CYP3A Inhibitors - pharmacology; Drug Interactions; drug‐drug interaction; Healthy Volunteers; Humans; itraconazole; Itraconazole - pharmacokinetics; pharmacokinetics; renal transporter; rifampicin; Rifampin - pharmacokinetics; serum creatinine; CYP3A; rifampicin; renal transporter; capmatinib; pharmacokinetics; itraconazole; drug-drug interaction; serum creatinine