Oncofetal protein glypican‐3 is a biomarker and critical regulator of function for neuroendocrine cells in prostate cancer

• Published in: The Journal of pathology Vol. 260; no. 1; pp. 43 - 55
• Main Authors: Butler, William, Xu, Lingfan, Zhou, Yinglu, Cheng, Qing, Hauck, J. Spencer, He, Yiping, Marek, Robert, Hartman, Zachary, Cheng, Liang, Yang, Qing, Wang, Mu‐En, Chen, Ming, Zhang, Hong, Armstrong, Andrew J, Huang, Jiaoti
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.05.2023; Wiley Subscription Services, Inc
• Subjects: Adenocarcinoma; Adenocarcinoma - pathology; Androgen receptors; biomarkers; Biomarkers - metabolism; Calcium homeostasis; Calcium signalling; Castration; Cell differentiation; Cell surface; cellular heterogeneity; Epithelial cells; genitourinary oncology; Glypicans - metabolism; Heparan sulfate proteoglycans; Homeostasis; Humans; immunotherapy; Liver cancer; Male; Neoplasm Recurrence, Local - pathology; neuroendocrine; Neuroendocrine Cells - metabolism; Neuroendocrine Cells - pathology; Precision medicine; precision oncology; Prostate cancer; Prostatic Neoplasms - pathology; Toxicity; Tumor cells; Tumors; precision oncology; prostate cancer; neuroendocrine; biomarkers; immunotherapy; cellular heterogeneity; genitourinary oncology

Neuroendocrine (NE) cells comprise ~1% of epithelial cells in benign prostate and prostatic adenocarcinoma (PCa). However, they become enriched in hormonally treated and castration‐resistant PCa (CRPC). In addition, close to 20% of hormonally treated tumors recur as small cell NE carcinoma (SCNC), c...