Pharmacokinetics of indinavir/ritonavir (800/100 mg) in combination with efavirenz (600 mg) in HIV-1-infected subjects

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 34; no. 2; p. 134
• Main Authors: Boyd, Mark A, Aarnoutse, Rob E, Ruxrungtham, Kiat, Stek, Jr, Michael, van Heeswijk, Rolf P G, Lange, Joep M A, Cooper, David A, Phanuphak, Praphan, Burger, David M
• Format: Journal Article
• Language: English
• Published: United States 01.10.2003
• Subjects: Acquired Immunodeficiency Syndrome - drug therapy; Adult; Anti-HIV Agents - pharmacokinetics; Benzoxazines; Drug Therapy, Combination; Female; HIV-1; Humans; Indinavir - pharmacokinetics; Male; Oxazines - pharmacokinetics; Ritonavir - pharmacokinetics

Addition of efavirenz (600 mg) to indinavir/ritonavir (800/100 mg) results in significant decreases in indinavir levels in healthy volunteers. This study evaluated the steady-state pharmacokinetics of indinavir/ritonavir at 800/100 mg twice daily (bid) in combination with efavirenz at 600 mg once da...