Acute systemic myeloid inflammatory and stress response in severe food allergic reactions

• Published in: Clinical and experimental allergy Vol. 53; no. 5; pp. 536 - 549
• Main Authors: Sharma, Ankit, Rijavec, Matija, Tomar, Sunil, Yamani, Amnah, Ganesan, Varsha, Krempski, James, Schuler, Charles F., Bunyavanich, Supinda, Korosec, Peter, Hogan, Simon P.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2023
• Subjects: Allergens; Animal models; Animals; Biological Phenomena; Cellular stress response; Food allergies; food allergy; Food Hypersensitivity - genetics; Gene expression; Gene mapping; Genes; Humans; IgE; Immune response; Immunoglobulin E; Immunology; Inflammation; Leukocytes (neutrophilic); Leukocytes, Mononuclear; MAP kinase; Mice; Monocytes; neutrophils; NF-κB protein; Peanut Hypersensitivity; Peripheral blood mononuclear cells; Receptors, G-Protein-Coupled; Transcriptomes; Transcriptomics; monocytes; food allergy; neutrophils; IgE

Introduction Food allergic reactions can be severe and potentially life‐threatening and the underlying immunological processes that contribute to the severity of reactions are poorly understood. The aim of this study is to integrate bulk RNA‐sequencing of human and mouse peripheral blood mononuclear...