Effect of highly active antiretroviral therapy on the natural history of anal squamous intraepithelial lesions and anal human papillomavirus infection

• Published in: Journal of acquired immune deficiency syndromes (1999) Vol. 28; no. 5; p. 422
• Main Authors: Palefsky, J M, Holly, E A, Ralston, M L, Da Costa, M, Bonner, H, Jay, N, Berry, J M, Darragh, T M
• Format: Journal Article
• Language: English
• Published: United States 15.12.2001
• Subjects: Adult; Aged; Anal Canal - pathology; Anal Canal - virology; Anti-HIV Agents - therapeutic use; Antiretroviral Therapy, Highly Active; Anus Neoplasms - drug therapy; Anus Neoplasms - pathology; Cohort Studies; Homosexuality, Male; Humans; Male; Middle Aged; Neoplasms, Squamous Cell - drug therapy; Neoplasms, Squamous Cell - pathology; Papillomaviridae; Papillomavirus Infections - drug therapy; Papillomavirus Infections - pathology

The effect of highly active antiretroviral therapy (HAART) on the natural history of anal squamous intraepithelial lesions (ASIL)-the likely anal cancer precursor-and anal human papillomavirus (HPV) infection is unknown. ASIL severity and level of anal HPV DNA were evaluated among HIV-positive men w...