In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction

• Published in: American journal of hematology Vol. 98; no. 7; pp. 1017 - 1028
• Main Authors: D'Alessandro, Angelo, Nouraie, S. Mehdi, Zhang, Yingze, Cendali, Francesca, Gamboni, Fabia, Reisz, Julie A., Zhang, Xu, Bartsch, Kyle W., Galbraith, Matthew D., Gordeuk, Victor R., Gladwin, Mark T.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.07.2023; Wiley Subscription Services, Inc
• Subjects: Anemia, Sickle Cell; Creatinine; Erythrocytes; Erythrocytes - metabolism; Genotypes; Glycolysis; Hematology; Hemoglobin; Hemoglobin, Sickle - metabolism; Hemolytic anemia; Humans; Intermediates; Metabolism; Metabolomics; Pyruvate kinase; Pyruvates - metabolism; Pyruvic acid; Renal function; Sickle cell disease; Sickle Cell Trait; Uric acid

Despite a wealth of exploratory plasma metabolomics studies in sickle cell disease (SCD), no study to date has evaluate a large and well phenotyped cohort to compare the primary erythrocyte metabolome of hemoglobin SS, SC and transfused AA red blood cells (RBCs) in vivo. The current study evaluates...