The impact of DNA double‐strand break repair pathways throughout the carbon ion spread‐out Bragg peak beam

• Published in: Cancer science Vol. 114; no. 12; pp. 4548 - 4557
• Main Authors: Buglewicz, Dylan J., Buglewicz, Jessica K. F., Hirakawa, Hirokazu, Kato, Takamitsu A., Liu, Cuihua, Fang, YaQun, Kusumoto, Tamon, Fujimori, Akira, Sai, Sei
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2023; John Wiley and Sons Inc
• Subjects: Animals; Bragg peak; Carbon; carbon ion radiotherapy; Cell culture; Cell survival; CHO Cells; Cricetinae; Cricetulus; Cytotoxicity; DNA; DNA Breaks, Double-Stranded; DNA damage; DNA damage and repair; DNA End-Joining Repair; DNA Repair; Dosimetry; Double-strand break repair; gamma‐H2AX; Homologous recombination; Humans; Ion beams; Kinases; Mammalian cells; NHEJ; Non-homologous end joining; Original; Ovaries; Radiation therapy; Radiosensitivity; Tumor cells; Yeast; Bragg peak; HR; DNA damage and repair; NHEJ; carbon ion radiotherapy; gamma-H2AX

Following carbon ion beam irradiation in mammalian cells, such as used in carbon ion radiotherapy (CIRT), it has been suggested that the balance between whether nonhomologous end joining (NHEJ) or homologous recombination (HR) is utilized depends on the DNA double‐strand break (DSB) complexity. Here...