Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis

• Published in: Brain pathology (Zurich, Switzerland) Vol. 35; no. 4; pp. e13322 - n/a
• Main Authors: Magliozzi, R., Hametner, S., Mastantuono, M., Mensi, A., Karimian, M., Griffiths, L., Watkins, L. M., Poli, A., Berti, G. M., Barusolo, E., Bellini, B., Rossi, S., Gveric, D., Stratton, J. A., Akassoglou, K., Magon, S., Nicholas, R., Reynolds, R., Howell, O. W., Monaco, S.
• Format: Journal Article
• Language: English
• Published: Switzerland John Wiley & Sons, Inc 01.07.2025; John Wiley and Sons Inc
• Subjects: Adult; Aged; Antigen presentation; Antigen processing; CD11c antigen; CD163 antigen; Cerebrospinal fluid; Choroid plexus; Choroid Plexus - immunology; Choroid Plexus - metabolism; Choroid Plexus - pathology; Correlation; CXCL13 protein; Female; Fibrinogen; Gene expression; Gene sequencing; gradient; Humans; Immune response; Immune system; Immunofluorescence; Inflammation; Inflammation - pathology; Innate immunity; Macrophages; Macrophages - pathology; Major histocompatibility complex; Male; Microglia; Middle Aged; Multiple sclerosis; Multiple Sclerosis - pathology; Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid; Multiple Sclerosis, Chronic Progressive - immunology; Multiple Sclerosis, Chronic Progressive - pathology; Neuropathology; Phenotypes; Sequence analysis; Ventricle (lateral); Ventricles (cerebral); inflammation; multiple sclerosis; gradient; choroid plexus
• ISSN: 1015-6305; 1750-3639; 1750-3639
• DOI: 10.1111/bpa.13322

Among the intrathecal inflammatory niches where compartmentalized inflammation persists and plays a pivotal role in progressive multiple sclerosis (MS), choroid plexus (CP) has recently received renewed attention. To better characterize the neuropathological/molecular correlates of CP in progressive...