The Discovery of New Cyanobactins from Cyanothece PCC 7425 Defines a New Signature for Processing of Patellamides

• Published in: Chembiochem : a European journal of chemical biology Vol. 13; no. 18; pp. 2683 - 2689
• Main Authors: Houssen, Wael E., Koehnke, Jesko, Zollman, David, Vendome, Jeremie, Raab, Andrea, Smith, Margaret C. M., Naismith, James H., Jaspars, Marcel
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 21.12.2012; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Subjects: Amino Acid Sequence; Biochemistry & Molecular Biology; biosynthetic engineering; Chemistry, Medicinal; Crystal structure; cyanobactins; Cyanothece - metabolism; Life Sciences & Biomedicine; Models, Molecular; Molecular Sequence Data; natural products; Peptides, Cyclic - chemistry; Peptides, Cyclic - metabolism; Pharmacology & Pharmacy; Protein Processing, Post-Translational; Protein Structure, Tertiary; ribosomal peptides; Science & Technology; Serine Proteases - chemistry; Serine Proteases - metabolism; subtilisin proteases; subtilisin proteases; SUBTILISIN; ribosomal peptides; cyanobactins; biosynthetic engineering; PEPTIDE; MARINE NATURAL-PRODUCTS; REFINEMENT; natural products; GENE-CLUSTER; BIOSYNTHESIS; SEQUENCE; EXPRESSION; MACROCYCLIZATION; LISSOCLINUM-PATELLA

Cyanobactins, including patellamides, are a group of cyanobacterial post‐translationally modified ribosomal cyclic peptides. The final product should in theory be predictable from the sequence of the precursor peptide and the associated tailoring enzymes. Understanding the mechanism and recognition...