Use of finger-prick dried blood spots (fpDBS) and capillary electrophoresis for carbohydrate deficient transferrin (CDT) screening in forensic toxicology

• Published in: Electrophoresis Vol. 37; no. 21; pp. 2867 - 2874
• Main Authors: Bertaso, Anna, Sorio, Daniela, Vandoros, Anthula, De Palo, Elio F., Bortolotti, Federica, Tagliaro, Franco
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.10.2016
• Subjects: Adult; Aged; Alcohol; Alcoholism - blood; Alcoholism - diagnosis; Blood; blood sampling; blood serum; capillary electrophoresis; CDT; centrifugation; Chromatography, High Pressure Liquid - methods; Dried Blood Spot Testing - methods; Electrophoresis; Electrophoresis, Capillary - methods; Female; Finger-prick dried blood spot; forensic sciences; Forensic Toxicology - methods; high performance liquid chromatography; HPLC; Humans; hydrochloric acid; iron; Limit of Detection; Linear Models; Male; Middle Aged; Reproducibility of Results; Samples; Screening; Screening analysis; Serums; Statistical analysis; Statistical methods; toxicology; Transferrin; Transferrin - analogs & derivatives; Transferrin - analysis; Alcohol; CDT; Screening analysis; Finger-prick dried blood spot; HPLC

Continued progress in chronic alcohol abuse investigation requires the development of less invasive procedures for screening purposes. The application of finger‐prick and related dried blood spots (fpDBS) for carbohydrate deficient transferrin (CDT) detection appears suitable for this aim. Therefore...