N‐acetylcysteine reduces cocaine‐seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine‐dependent individuals

• Published in: Addiction biology Vol. 26; no. 2; pp. e12900 - n/a
• Main Authors: Woodcock, Eric A., Lundahl, Leslie H., Khatib, Dalal, Stanley, Jeffrey A., Greenwald, Mark K.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2021
• Subjects: Acetylcysteine; Acetylcysteine - pharmacology; Acetylcysteine - therapeutic use; Adult; anterior cingulate cortex; Blindness; Cocaine; Cocaine-Related Disorders - drug therapy; Cross-Over Studies; Double-Blind Method; Drug-Seeking Behavior - drug effects; drug‐seeking behavior; Female; glutamate; Glutamic Acid - drug effects; Glutamine; Glutamine - drug effects; Gyrus Cinguli - drug effects; Humans; Magnetic resonance spectroscopy; Male; Middle Aged; N‐acetylcysteine; Placebos; Proton Magnetic Resonance Spectroscopy; Reinstatement; relapse; Reward; drug-seeking behavior; cocaine; relapse; anterior cingulate cortex; glutamate; N-acetylcysteine

N‐acetylcysteine (NAC) is a cystine prodrug shown to reduce cocaine‐ and cue‐primed reinstatement of cocaine‐seeking behavior in preclinical studies. In this inpatient study, the effects of NAC maintenance versus placebo on cocaine‐seeking behavior were examined during cocaine‐primed and unprimed se...