A neural circuit associated with anxiety‐like behaviors induced by chronic inflammatory pain and the anxiolytic effects of electroacupuncture

• Published in: CNS neuroscience & therapeutics Vol. 30; no. 4; pp. e14520 - n/a
• Main Authors: Wu, Zemin, Shen, Zui, Xu, Yingling, Chen, Shaozong, Xiao, Siqi, Ye, Jiayu, Zhang, Haiyan, Ma, Xinyi, Zhu, Yichen, Zhu, Xixiao, Jiang, Yongliang, Fang, Junfan, Liu, Boyi, He, Xiaofen, Gao, Shuzhong, Shao, Xiaomei, Liu, Jinggen, Fang, Jianqiao
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2024; John Wiley and Sons Inc
• Subjects: Acupuncture; Animals; Anti-Anxiety Agents - pharmacology; Anxiety; Anxiety - drug therapy; anxiety‐like behavior; Behavior; Ca2+/calmodulin-dependent protein kinase II; Calcium-Calmodulin-Dependent Protein Kinase Type 2; chronic inflammatory pain; Chronic pain; Chronic Pain - chemically induced; Chronic Pain - therapy; Comorbidity; Cortex (cingulate); Dorsal raphe nucleus; Electroacupuncture; Emotional disorders; Emotions; Freund's adjuvant; gamma-Aminobutyric Acid - pharmacology; Inflammation; Life sciences; Mood disorders; Neurons; Original; Raphe nuclei; Rats; rostral anterior cingulate cortex; Serotonergic Neurons; Serotonin; Synaptic transmission; Viruses; γ-Aminobutyric acid; United States > US; China; dorsal raphe nucleus; anxiety‐like behavior; rostral anterior cingulate cortex; chronic inflammatory pain; electroacupuncture; serotonergic neurons

Aims Negative emotions induced by chronic pain are a serious clinical problem. Electroacupuncture (EA) is a clinically proven safe and effective method to manage pain‐related negative emotions. However, the circuit mechanisms underlying the effect of EA treatment on negative emotions remain unclear....