A Sos proteomimetic as a pan-Ras inhibitor

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 18; pp. 1 - 11
• Main Authors: Hong, Seong Ho, Yoo, Daniel Y., Conway, Louis, Richards-Corke, Khyle C., Parker, Christopher G., Arora, Paramjit S.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 04.05.2021
• Subjects: Biological Sciences; Crystal structure; Guanine; Guanine nucleotide exchange factor; Kinases; Mutation; Nucleotides; Physical Sciences; Proteolysis; Ras protein; Signal transduction; Signaling; peptide; proteomimetic; Ras; Sos

Aberrant Ras signaling is linked to a wide spectrum of hyperproliferative diseases, and components of the signaling pathway, including Ras, have been the subject of intense and ongoing drug discovery efforts. The cellular activity of Ras is modulated by its association with the guanine nucleotide ex...