Growth and Translation Inhibition through Sequence-specific RNA Binding by Mycobacterium tuberculosis VapC Toxin

• Published in: The Journal of biological chemistry Vol. 287; no. 16; pp. 12835 - 12847
• Main Authors: Sharp, Jared D., Cruz, Jonathan W., Raman, Sahadevan, Inouye, Masayori, Husson, Robert N., Woychik, Nancy A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.04.2012; American Society for Biochemistry and Molecular Biology
• Subjects: Antitoxin; Antitoxins - genetics; Antitoxins - metabolism; Bacterial Toxins; Bacterial Toxins - genetics; Bacterial Toxins - metabolism; DNA, Bacterial - metabolism; Enzymology; Escherichia coli - genetics; Latency; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - growth & development; Mycobacterium tuberculosis - metabolism; Protein Biosynthesis - physiology; Protein Synthesis; Ribonuclease; Ribosomes - genetics; Ribosomes - metabolism; RNA; RNA, Bacterial - metabolism; RNA, Messenger - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Translation; Tuberculosis; Virulence Factors; Virulence Factors - genetics; Virulence Factors - metabolism; Translation; Protein Synthesis; Tuberculosis; RNA; Bacterial Toxins; Antitoxin; Ribonuclease; Virulence Factors; Latency

The Mycobacterium tuberculosis genome harbors an unusually large number of toxin-antitoxin (TA) modules. Curiously, over half of these are VapBC (virulence-associated protein) family members. Nonetheless, the cellular target, precise mode of action, and physiological role of the VapC toxins in this...