Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis

• Published in: The Journal of biological chemistry Vol. 289; no. 43; pp. 29751 - 29765
• Main Authors: Jiang, Shan, Yan, Cheng, Fang, Qi-chen, Shao, Meng-le, Zhang, Yong-liang, Liu, Yang, Deng, Yi-ping, Shan, Bo, Liu, Jing-qi, Li, Hua-ting, Yang, Liu, Zhou, Jian, Dai, Zhi, Liu, Yong, Jia, Wei-ping
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.10.2014; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Base Sequence; Diet; DNA-Binding Proteins - metabolism; Endoplasmic Reticulum Stress - genetics; Endoribonucleases - metabolism; Enzyme Activation - drug effects; Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors; Extracellular Signal-Regulated MAP Kinases - metabolism; Fatty Liver - genetics; Fatty Liver - pathology; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Hep G2 Cells; Hepatocytes - drug effects; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; Male; Mice, Inbred C57BL; Mice, Obese; Molecular Biophysics; Molecular Sequence Data; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Organ Specificity - drug effects; Organ Specificity - genetics; Promoter Regions, Genetic - genetics; Protein-Serine-Threonine Kinases - metabolism; Recombinant Proteins - pharmacology; Regulatory Factor X Transcription Factors; Signal Transduction - drug effects; Signal Transduction - genetics; Transcription Factors - metabolism; Transcription, Genetic - drug effects; Transcriptional Activation - drug effects; Transcriptional Activation - genetics; Unfolded Protein Response - drug effects; Unfolded Protein Response - genetics; X-Box Binding Protein 1; Unfolded Protein Response (UPR); Fibroblast Growth Factor (FGF); Liver Metabolism; ER Stress; Hepatocyte

Endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR) and represents a critical mechanism that underlies metabolic dysfunctions. Fibroblast growth factor 21 (FGF21), a hormone that is predominantly secreted by the liver, exerts a broad range of effects upon the met...