Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis - Jiang, Shan; Yan, Cheng; Fang, Qi-chen; Shao, Meng-le; Zhang, Yong-liang; Liu, Yang; Deng, Yi-ping; Shan, Bo; Liu, Jing-qi; Li, Hua-ting; Yang, Liu; Zhou, Jian; et al. (The Journal of biological chemistry, 2014)
Keywords: Animals; Base Sequence; Diet; DNA-Binding Proteins - metabolism; Endoplasmic Reticulum Stress - genetics; Endoribonucleases - metabolism; Enzyme Activation - drug effects; Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors; Extracellular Signal-Regulated MAP Kinases - metabolism; Fatty Liver - genetics; Fatty Liver - pathology; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Hep G2 Cells; Hepatocytes - drug effects; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; Male; Mice, Inbred C57BL; Mice, Obese; Molecular Biophysics; Molecular Sequence Data; Non-alcoholic Fatty Liver Disease - metabolism; Non-alcoholic Fatty Liver Disease - pathology; Organ Specificity - drug effects; Organ Specificity - genetics; Promoter Regions, Genetic - genetics; Protein-Serine-Threonine Kinases - metabolism; Recombinant Proteins - pharmacology; Regulatory Factor X Transcription Factors; Signal Transduction - drug effects; Signal Transduction - genetics; Transcription Factors - metabolism; Transcription, Genetic - drug effects; Transcriptional Activation - drug effects; Transcriptional Activation - genetics; Unfolded Protein Response - drug effects; Unfolded Protein Response - genetics; X-Box Binding Protein 1; Unfolded Protein Response (UPR); Fibroblast Growth Factor (FGF); Liver Metabolism; ER Stress; Hepatocyte