Antiviral combination therapies for persistent COVID-19 in immunocompromised patients

• Published in: International journal of infectious diseases Vol. 137; pp. 55 - 59
• Main Authors: Focosi, Daniele, Maggi, Fabrizio, D'Abramo, Alessandra, Nicastri, Emanuele, Sullivan, David J
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2023; Elsevier
• Subjects: Combination therapies; COVID-19; Immunocompromised; SARS-CoV-2; COVID-19; SARS-CoV-2; Combination therapies; Immunocompromised

•Immunocompromised patients require combined antiviral therapies.•In vitro synergies exist for small molecule antivirals and passive immunotherapies.•Anti-spike monoclonal antibodies lost efficacy against recent Omicron variants.•Small molecule antivirals can be combined with increased efficacy.•Com...