A dual agonist of farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice

• Published in: The Journal of biological chemistry Vol. 292; no. 29; pp. 12018 - 12024
• Main Authors: Wang, Xiaoxin X., Luo, Yuhuan, Wang, Dong, Adorini, Luciano, Pruzanski, Mark, Dobrinskikh, Evgenia, Levi, Moshe
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.07.2017; American Society for Biochemistry and Molecular Biology
• Subjects: Accelerated Communications; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; bile acid; Bile Acids and Salts - pharmacology; Bile Acids and Salts - therapeutic use; Caloric Restriction; Cells, Cultured; Gene Expression Regulation, Developmental; Humans; Hypolipidemic Agents - pharmacology; Hypolipidemic Agents - therapeutic use; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - metabolism; kidney; Kidney - drug effects; Kidney - immunology; Kidney - metabolism; Kidney - pathology; Longevity; Mice, Inbred C57BL; Mice, Mutant Strains; Mitochondria - enzymology; Mitochondria - immunology; Mitochondria - metabolism; Mitochondria - pathology; mitochondrial metabolism; Mitochondrial Turnover; Podocytes - drug effects; Podocytes - immunology; Podocytes - metabolism; Podocytes - pathology; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; Receptors, G-Protein-Coupled - agonists; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Renal Insufficiency - drug therapy; Renal Insufficiency - metabolism; Renal Insufficiency - pathology; Renal Insufficiency - prevention & control; kidney; aging; bile acid; kidney metabolism; mitochondrial metabolism

Even in healthy individuals, renal function gradually declines during aging. However, an observed variation in the rate of this decline has raised the possibility of slowing or delaying age-related kidney disease. One of the most successful interventional measures that slows down and delays age-rela...