A dual agonist of farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice - Wang, Xiaoxin X.; Luo, Yuhuan; Wang, Dong; Adorini, Luciano; Pruzanski, Mark; Dobrinskikh, Evgenia; Levi, Moshe (The Journal of biological chemistry, 2017)
Keywords: Accelerated Communications; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; bile acid; Bile Acids and Salts - pharmacology; Bile Acids and Salts - therapeutic use; Caloric Restriction; Cells, Cultured; Gene Expression Regulation, Developmental; Humans; Hypolipidemic Agents - pharmacology; Hypolipidemic Agents - therapeutic use; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - metabolism; kidney; Kidney - drug effects; Kidney - immunology; Kidney - metabolism; Kidney - pathology; Longevity; Mice, Inbred C57BL; Mice, Mutant Strains; Mitochondria - enzymology; Mitochondria - immunology; Mitochondria - metabolism; Mitochondria - pathology; mitochondrial metabolism; Mitochondrial Turnover; Podocytes - drug effects; Podocytes - immunology; Podocytes - metabolism; Podocytes - pathology; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; Receptors, G-Protein-Coupled - agonists; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Renal Insufficiency - drug therapy; Renal Insufficiency - metabolism; Renal Insufficiency - pathology; Renal Insufficiency - prevention & control; kidney; aging; bile acid; kidney metabolism; mitochondrial metabolism