SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer

• Published in: Cancer letters Vol. 530; pp. 142 - 155
• Main Authors: Li, Tian-Jiao, Jin, Kai-Zhou, Li, Hao, Ye, Long-Yun, Li, Peng-Cheng, Jiang, Bruce, Lin, Xuan, Liao, Zhen-Yu, Zhang, Hui-Ru, Shi, Sai-Meng, Lin, Meng-Xiong, Fei, Qing-Lin, Xiao, Zhi-Wen, Xu, Hua-Xiang, Liu, Liang, Yu, Xian-Jun, Wu, Wei-Ding
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2022; Elsevier Limited
• Subjects: Acids; Adenocarcinoma; Animals; Apoptosis; Cancer therapies; Carcinoma, Pancreatic Ductal - genetics; Cell culture; Cell Line, Tumor; Chemokines; Chemotherapy; Clinical significance; Cytokines; Cytokines - genetics; Enzymes; Experiments; Gene Expression Regulation, Neoplastic - genetics; Humans; Immune checkpoint inhibitors; Immunoglobulins - genetics; Immunoregulation; Immunosuppression Therapy - methods; Lectins; Lymphocytes T; Macrophages; Membrane Proteins - genetics; Metastases; Mice; Mice, Inbred C57BL; Microenvironments; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - genetics; PDAC; Phenotypes; Phosphorylation; Proteins; Sialic acid; Sialic acids; SIGLEC15; Sodium; Surgery; SYK; Syk protein; T-Lymphocytes - pathology; TAM; THP-1 Cells; Tumor Microenvironment - genetics; Tumor-Associated Macrophages - pathology; Tumors; Visualization; TAM; SIGLEC15; Sialic acid; PDAC; SYK

Pancreatic ductal adenocarcinoma (PDAC) usually presents infrequent infiltration of T lymphocytes. The known immune-checkpoint inhibitors to date focus on activating T cells and manifest limited effectiveness in PDAC. SIGLEC15 was identified as a novel tumor-associated macrophage (TAM)-related immun...