SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer - Li, Tian-Jiao; Jin, Kai-Zhou; Li, Hao; Ye, Long-Yun; Li, Peng-Cheng; Jiang, Bruce; Lin, Xuan; Liao, Zhen-Yu; Zhang, Hui-Ru; Shi, Sai-Meng; Lin, Meng-Xiong; Fei, Qing-Lin; et al. (Cancer letters, 2022)
Keywords: Acids; Adenocarcinoma; Animals; Apoptosis; Cancer therapies; Carcinoma, Pancreatic Ductal - genetics; Cell culture; Cell Line, Tumor; Chemokines; Chemotherapy; Clinical significance; Cytokines; Cytokines - genetics; Enzymes; Experiments; Gene Expression Regulation, Neoplastic - genetics; Humans; Immune checkpoint inhibitors; Immunoglobulins - genetics; Immunoregulation; Immunosuppression Therapy - methods; Lectins; Lymphocytes T; Macrophages; Membrane Proteins - genetics; Metastases; Mice; Mice, Inbred C57BL; Microenvironments; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - genetics; PDAC; Phenotypes; Phosphorylation; Proteins; Sialic acid; Sialic acids; SIGLEC15; Sodium; Surgery; SYK; Syk protein; T-Lymphocytes - pathology; TAM; THP-1 Cells; Tumor Microenvironment - genetics; Tumor-Associated Macrophages - pathology; Tumors; Visualization; TAM; SIGLEC15; Sialic acid; PDAC; SYK