UBD modifies APOL1-induced kidney disease risk

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 13; pp. 3446 - 3451
• Main Authors: Zhang, Jia-Yue, Wang, Minxian, Tian, Lei, Genovese, Giulio, Yan, Paul, Wilson, James G., Thadhani, Ravi, Mottl, Amy K., Appel, Gerald B., Bick, Alexander G., Sampson, Matthew G., Alper, Seth L., Friedman, David J., Pollak, Martin R.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.03.2018
• Subjects: Admixtures; Alleles; Apolipoproteins; Apoptosis; Biological Sciences; Gene expression; Gene mapping; Genes; Genetic code; Genotype & phenotype; Genotypes; Health risks; Heredity; Inflammation; Kidney diseases; Kidneys; L1 gene; Loci; Phenotypes; Proteasomes; Proteins; Risk; Toxicity; Ubiquitin; FSGS; FAT10; kidney; APOL1; UBD

People of recent African ancestry develop kidney disease at much higher rates than most other groups. Two specific coding variants in the Apolipoprotein-L1 gene APOL1 termed G1 and G2 are the causal drivers of much of this difference in risk, following a recessive pattern of inheritance. However, mo...