BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer
We have recently demonstrated that a natural dietary supplement BreastDefend (BD), which contains extracts from medicinal mushrooms (Coriolus versicolor, Ganoderma lucidum, Phellinus linteus), medicinal herbs (Scutellaria barbata, Astragalus membranaceus, Curcuma longa), and purified biologically ac...
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Published in | Oncology reports Vol. 28; no. 4; pp. 1139 - 1145 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
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D.A. Spandidos
01.10.2012
Spandidos Publications UK Ltd |
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Abstract | We have recently demonstrated that a natural dietary supplement BreastDefend (BD), which contains extracts from medicinal mushrooms (Coriolus versicolor, Ganoderma lucidum, Phellinus linteus), medicinal herbs (Scutellaria barbata, Astragalus membranaceus, Curcuma longa), and purified biologically active nutritional compounds (diindolylmethane and quercetin), inhibits proliferation and metastatic behavior of MDA-MB-231 invasive human breast cancer cells in vitro. In the present study, we evaluated whether BD suppresses growth and breast-to lung cancer metastasis in an orthotopic model of human breast cancer cells implanted in mice. Oral application of BD (100 mg/kg of body weight for 4 weeks) by intragastric gavage did not affect body weight or activity of liver enzymes and did not show any sign of toxicity in liver, spleen, kidney, lung and heart tissues in mice. Moreover, BD significantly decreased the change in tumor volume over time compared to the control group (p=0.002). BD treatment also markedly decreased the incidence of breast-to-lung cancer metastasis from 67% (control) to 20% (BD) (p<0.05) and the number of metastases from 2.8 (0.0, 48.0) in the control group to 0.0 (0.0, 14.2) in the BD treatment group (p<0.05). Finally, anti-metastatic activity of BD in vivo was further confirmed by the downregulation of expression of PLAU (urokinase plasminogen activator, uPA) and CXCR4 (C-X-C chemokine receptor-4) genes in breast tumors. In conclusion, BD may be considered as a biological therapeutic agent against invasive breast cancers. |
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AbstractList | We have recently demonstrated that a natural dietary supplement BreastDefend (BD), which contains extracts from medicinal mushrooms (Coriolus versicolor, Ganoderma lucidum, Phellinus linteus), medicinal herbs (Scutellaria barbata, Astragalus membranaceus, Curcuma longa), and purified biologically active nutritional compounds (diindolylmethane and quercetin), inhibits proliferation and metastatic behavior of MDA-MB-231 invasive human breast cancer cells in vitro. In the present study, we evaluated whether BD suppresses growth and breast-to lung cancer metastasis in an orthotopic model of human breast cancer cells implanted in mice. Oral application of BD (100 mg/kg of body weight for 4 weeks) by intragastric gavage did not affect body weight or activity of liver enzymes and did not show any sign of toxicity in liver, spleen, kidney, lung and heart tissues in mice. Moreover, BD significantly decreased the change in tumor volume over time compared to the control group (p=0.002). BD treatment also markedly decreased the incidence of breast-to-lung cancer metastasis from 67% (control) to 20% (BD) (p<0.05) and the number of metastases from 2.8 (0.0, 48.0) in the control group to 0.0 (0.0, 14.2) in the BD treatment group (p<0.05). Finally, anti-metastatic activity of BD in vivo was further confirmed by the downregulation of expression of PLAU (urokinase plasminogen activator, uPA) and CXCR4 (C-X-C chemokine receptor-4) genes in breast tumors. In conclusion, BD may be considered as a biological therapeutic agent against invasive breast cancers. We have recently demonstrated that a natural dietary supplement BreastDefend (BD), which contains extracts from medicinal mushrooms ( Coriolus versicolor, Ganoderma lucidum, Phellinus linteus ), medicinal herbs (S cutellaria barbata, Astragalus membranaceus, Curcuma longa ), and purified biologically active nutritional compounds (diindolylmethane and quercetin), inhibits proliferation and metastatic behavior of MDA-MB-231 invasive human breast cancer cells in vitro . In the present study, we evaluated whether BD suppresses growth and breast-to lung cancer metastasis in an orthotopic model of human breast cancer cells implanted in mice. Oral application of BD (100 mg/kg of body weight for 4 weeks) by intragastric gavage did not affect body weight or activity of liver enzymes and did not show any sign of toxicity in liver, spleen, kidney, lung and heart tissues in mice. Moreover, BD significantly decreased the change in tumor volume over time compared to the control group (p=0.002). BD treatment also markedly decreased the incidence of breast-to-lung cancer metastasis from 67% (control) to 20% (BD) (p<0.05) and the number of metastases from 2.8 (0.0, 48.0) in the control group to 0.0 (0.0, 14.2) in the BD treatment group (p<0.05). Finally, anti-metastatic activity of BD in vivo was further confirmed by the downregulation of expression of PLAU (urokinase plasminogen activator, uPA) and CXCR4 (C-X-C chemokine receptor-4) genes in breast tumors. In conclusion, BD may be considered as a biological therapeutic agent against invasive breast cancers. |
Author | ELIAZ, ISAAC THYAGARAJAN-SAHU, ANITA TERRY, COLIN SLIVA, DANIEL JIANG, JIAHUA LOGANATHAN, JAGADISH SANDUSKY, GEORGE E |
AuthorAffiliation | 4 Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA 2 Amitabha Medical Clinic and Healing Center, Sebastopol, CA 1 Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202 3 Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA 5 Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA |
AuthorAffiliation_xml | – name: 3 Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA – name: 1 Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202 – name: 2 Amitabha Medical Clinic and Healing Center, Sebastopol, CA – name: 4 Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA – name: 5 Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA |
Author_xml | – sequence: 1 givenname: JIAHUA surname: JIANG fullname: JIANG, JIAHUA organization: Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202 – sequence: 2 givenname: ANITA surname: THYAGARAJAN-SAHU fullname: THYAGARAJAN-SAHU, ANITA organization: Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202 – sequence: 3 givenname: JAGADISH surname: LOGANATHAN fullname: LOGANATHAN, JAGADISH organization: Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202 – sequence: 4 givenname: ISAAC surname: ELIAZ fullname: ELIAZ, ISAAC organization: Amitabha Medical Clinic and Healing Center, Sebastopol, CA – sequence: 5 givenname: COLIN surname: TERRY fullname: TERRY, COLIN organization: Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202 – sequence: 6 givenname: GEORGE E surname: SANDUSKY fullname: SANDUSKY, GEORGE E organization: Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA – sequence: 7 givenname: DANIEL surname: SLIVA fullname: SLIVA, DANIEL organization: Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202 |
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Snippet | We have recently demonstrated that a natural dietary supplement BreastDefend (BD), which contains extracts from medicinal mushrooms (Coriolus versicolor,... We have recently demonstrated that a natural dietary supplement BreastDefend (BD), which contains extracts from medicinal mushrooms ( Coriolus versicolor,... |
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SubjectTerms | Administration, Oral Animals Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology C-X-C chemokine receptor-4 Cancer therapies Cell Line, Tumor dietary supplement Dietary supplements Dietary Supplements - adverse effects Disease Models, Animal Down-Regulation Female Gene Expression Regulation, Neoplastic - drug effects Good Manufacturing Practice Humans Laboratory animals Lung cancer lung cancer metastasis Lung Neoplasms - genetics Lung Neoplasms - prevention & control Lung Neoplasms - secondary Metastasis Mice Mice, Nude Plant Extracts - adverse effects Plant Extracts - pharmacology Plants, Medicinal - chemistry Proteins Receptors, CXCR4 - genetics Toxicity Toxicity Tests triple negative breast cancer cells Tumors urokinase plasminogen activator Urokinase-Type Plasminogen Activator - genetics Xenograft Model Antitumor Assays |
Title | BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer |
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