The relationship between birth timing, circuit wiring, and physiological response properties of cerebellar granule cells

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 23; pp. 1 - 11
• Main Authors: Shuster, S. Andrew, Wagner, Mark J., Pan-Doh, Nathan, Ren, Jing, Grutzner, Sophie M., Beier, Kevin T., Kim, Tony Hyun, Schnitzer, Mark J., Luo, Liqun
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 08.06.2021
• Subjects: Animals; Animals, Newborn; Axons; Biological Sciences; Birth; Calcium imaging; Calcium ions; Cerebellar Cortex - growth & development; Cerebellar Cortex - virology; Cerebellum; Granular materials; Granule cells; Lyssavirus; Mice; Mice, Transgenic; Motor nuclei; Nerve Fibers - metabolism; Nerve Fibers - virology; Nuclei (cytology); Parallel processing; Rabies; Rabies virus - metabolism; Reinforcement; Representations; Stimuli; Timer circuits; Viruses; Wiring; birth timing; rabies tracing; granule cells; two-photon Ca2+ imaging; cerebellum

Cerebellar granule cells (GrCs) are usually regarded as a uniform cell type that collectively expands the coding space of the cerebellum by integrating diverse combinations of mossy fiber inputs. Accordingly, stable molecularly or physiologically defined GrC subtypes within a single cerebellar regio...