The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

• Published in: The Journal of biological chemistry Vol. 295; no. 15; pp. 4773 - 4779
• Main Authors: Gordon, Calvin J., Tchesnokov, Egor P., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.04.2020; American Society for Biochemistry and Molecular Biology
• Subjects: Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - chemistry; Adenosine Monophosphate - pharmacology; Alanine - analogs & derivatives; Alanine - chemistry; Alanine - pharmacology; Animals; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; antiviral drug; coronavirus; Coronavirus - enzymology; drug development; Ebola virus (EBOV); Ebolavirus - enzymology; Editors' Picks; enzyme inhibitor; Gene Expression; Middle East respiratory syndrome coronavirus (MERS–CoV); Middle East Respiratory Syndrome Coronavirus - enzymology; Nucleic Acid Synthesis Inhibitors - chemistry; Nucleic Acid Synthesis Inhibitors - pharmacology; nucleoside/nucleotide analog; plus-stranded RNA virus; positive-sense RNA virus; remdesivir; RNA; RNA chain termination; RNA-dependent RNA polymerase (RdRp); RNA-Dependent RNA Polymerase - antagonists & inhibitors; RNA-Dependent RNA Polymerase - genetics; SARS–CoV-2; Sf9 Cells; Viral Nonstructural Proteins - genetics; viral polymerase; viral replicase; Virus Replication - drug effects; Ebola virus (EBOV); positive-sense RNA virus; Middle East respiratory syndrome coronavirus (MERS–CoV); drug development; coronavirus; RNA chain termination; remdesivir; viral replicase; RNA-dependent RNA polymerase (RdRp); SARS–CoV-2; viral polymerase; enzyme inhibitor; nucleoside/nucleotide analog; antiviral drug; plus-stranded RNA virus

Antiviral drugs for managing infections with human coronaviruses are not yet approved, posing a serious challenge to current global efforts aimed at containing the outbreak of severe acute respiratory syndrome–coronavirus 2 (CoV-2). Remdesivir (RDV) is an investigational compound with a broad spectr...