The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus - Gordon, Calvin J.; Tchesnokov, Egor P.; Feng, Joy Y.; Porter, Danielle P.; Götte, Matthias (The Journal of biological chemistry, 2020)
Keywords: Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - chemistry; Adenosine Monophosphate - pharmacology; Alanine - analogs & derivatives; Alanine - chemistry; Alanine - pharmacology; Animals; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; antiviral drug; coronavirus; Coronavirus - enzymology; drug development; Ebola virus (EBOV); Ebolavirus - enzymology; Editors' Picks; enzyme inhibitor; Gene Expression; Middle East respiratory syndrome coronavirus (MERS–CoV); Middle East Respiratory Syndrome Coronavirus - enzymology; Nucleic Acid Synthesis Inhibitors - chemistry; Nucleic Acid Synthesis Inhibitors - pharmacology; nucleoside/nucleotide analog; plus-stranded RNA virus; positive-sense RNA virus; remdesivir; RNA; RNA chain termination; RNA-dependent RNA polymerase (RdRp); RNA-Dependent RNA Polymerase - antagonists & inhibitors; RNA-Dependent RNA Polymerase - genetics; SARS–CoV-2; Sf9 Cells; Viral Nonstructural Proteins - genetics; viral polymerase; viral replicase; Virus Replication - drug effects; Ebola virus (EBOV); positive-sense RNA virus; Middle East respiratory syndrome coronavirus (MERS–CoV); drug development; coronavirus; RNA chain termination; remdesivir; viral replicase; RNA-dependent RNA polymerase (RdRp); SARS–CoV-2; viral polymerase; enzyme inhibitor; nucleoside/nucleotide analog; antiviral drug; plus-stranded RNA virus