Associations between Variants of the 8q24 Chromosome and Nine Smoking-Related Cancer Sites

Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24 SNPs have also been associated with colorectal cancer, suggesting that this region may not be specifically associated to just prostate cancer. T...

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Published inCancer epidemiology, biomarkers & prevention Vol. 17; no. 11; pp. 3193 - 3202
Main Authors Park, Sungshim Lani, Chang, Shen-Chih, Cai, Lin, Cordon-Cardo, Carlos, Ding, Bao-Guo, Greenland, Sander, Hussain, Shehnaz K., Jiang, Qingwu, Liu, Simin, Lu, Ming-Lan, Mao, Jenny T., Morgenstern, Hal, Mu, Li-Na, Ng, Leslie J., Pantuck, Allan, Rao, Jianyu, Reuter, Victor E., Tashkin, Donald P., You, Nai-Chieh Y., Yu, Can-Qing, Yu, Shun-Zhang, Zhao, Jin-Kou, Belldegrun, Arie, Zhang, Zuo-Feng
Format Journal Article
LanguageEnglish
Published United States American Association for Cancer Research 01.11.2008
Subjects
8q24 polymorphisms
Adolescent
Adult
Aged
Alleles
bladder
Case-Control Studies
Chi-Square Distribution
Chromosomes, Human, Pair 8 - genetics
esophagus
Female
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
kidney
larynx
liver
Liver Neoplasms - ethnology
Liver Neoplasms - genetics
lung
Lung Neoplasms - ethnology
Lung Neoplasms - genetics
Male
Middle Aged
nasopharynx
neoplasms
Neoplasms - ethnology
Neoplasms - genetics
oropharynx
Otorhinolaryngologic Neoplasms - ethnology
Otorhinolaryngologic Neoplasms - genetics
Polymorphism, Single Nucleotide
Risk
Smoking - genetics
smoking-related cancers
SNP
stomach
Urinary Bladder Neoplasms - ethnology
Urinary Bladder Neoplasms - genetics
Online AccessGet full text
ISSN1055-9965
1538-7755
DOI10.1158/1055-9965.EPI-08-0523

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Abstract Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24 SNPs have also been associated with colorectal cancer, suggesting that this region may not be specifically associated to just prostate cancer. To date, the association between these polymorphisms and tobacco smoking-related cancer sites remains unknown. Using epidemiologic data and biological samples previously collected in three case-control studies from U.S. and Chinese populations, we selected and genotyped one SNP from each of the three previously determined “regions” within the 8q24 loci, rs1447295 (region 1), rs16901979 (region 2), and rs6983267 (region 3), and examined their association with cancers of the lung, oropharynx, nasopharynx, larynx, esophagus, stomach, liver, bladder, and kidney. We observed noteworthy associations between rs6983267 and upper aerodigestive tract cancers [adjusted odds ratio (OR adj ), 1.69; 95% confidence interval (95% CI), 1.28-2.24], particularly in oropharynx (OR adj , 1.80; 95% CI, 1.30-2.49) and larynx (OR adj , 2.04; 95% CI, 1.12-3.72). We also observed a suggestive association between rs6983267 and liver cancer (OR adj , 1.51; 95% CI, 0.99-2.31). When we stratified our analysis by smoking status, rs6983267 was positively associated with lung cancer among ever-smokers (OR adj , 1.45; 95% CI, 1.05-2.00) and inversely associated with bladder cancer among ever-smokers (OR adj , 0.35; 95% CI, 0.14-0.83). Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers. Our results suggest variants of the 8q24 chromosome may play an important role in smoking-related cancer development. Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3193–202)
AbstractList Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24 SNPs have also been associated with colorectal cancer, suggesting that this region may not be specifically associated to just prostate cancer. To date, the association between these polymorphisms and tobacco smoking-related cancer sites remains unknown. Using epidemiologic data and biological samples previously collected in three case-control studies from U.S. and Chinese populations, we selected and genotyped one SNP from each of the three previously determined "regions" within the 8q24 loci, rs1447295 (region 1), rs16901979 (region 2), and rs6983267 (region 3), and examined their association with cancers of the lung, oropharynx, nasopharynx, larynx, esophagus, stomach, liver, bladder, and kidney. We observed noteworthy associations between rs6983267 and upper aerodigestive tract cancers [adjusted odds ratio (ORadj), 1.69; 95% confidence interval (95% CI), 1.28-2.24], particularly in oropharynx (ORadj, 1.80; 95% CI, 1.30-2.49) and larynx (ORadj, 2.04; 95% CI, 1.12-3.72). We also observed a suggestive association between rs6983267 and liver cancer (ORadj, 1.51; 95% CI, 0.99-2.31). When we stratified our analysis by smoking status, rs6983267 was positively associated with lung cancer among ever-smokers (ORadj, 1.45; 95% CI, 1.05-2.00) and inversely associated with bladder cancer among ever-smokers (ORadj, 0.35; 95% CI, 0.14-0.83). Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers. Our results suggest variants of the 8q24 chromosome may play an important role in smoking-related cancer development. Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers.
Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24 SNPs have also been associated with colorectal cancer, suggesting that this region may not be specifically associated to just prostate cancer. To date, the association between these polymorphisms and tobacco smoking-related cancer sites remains unknown. Using epidemiologic data and biological samples previously collected in three case-control studies from U.S. and Chinese populations, we selected and genotyped one SNP from each of the three previously determined “regions” within the 8q24 loci, rs1447295 (region 1), rs16901979 (region 2), and rs6983267 (region 3), and examined their association with cancers of the lung, oropharynx, nasopharynx, larynx, esophagus, stomach, liver, bladder, and kidney. We observed noteworthy associations between rs6983267 and upper aerodigestive tract cancers [adjusted odds ratio (ORadj), 1.69; 95% confidence interval (95% CI), 1.28-2.24], particularly in oropharynx (ORadj, 1.80; 95% CI, 1.30-2.49) and larynx (ORadj, 2.04; 95% CI, 1.12-3.72). We also observed a suggestive association between rs6983267 and liver cancer (ORadj, 1.51; 95% CI, 0.99-2.31). When we stratified our analysis by smoking status, rs6983267 was positively associated with lung cancer among ever-smokers (ORadj, 1.45; 95% CI, 1.05-2.00) and inversely associated with bladder cancer among ever-smokers (ORadj, 0.35; 95% CI, 0.14-0.83). Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers. Our results suggest variants of the 8q24 chromosome may play an important role in smoking-related cancer development. Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3193–202)
Recent genome-wide association (GWA) studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24 SNPs have also been associated with colorectal cancer, suggesting this region may not be specifically associated to just prostate cancer. To date, the association between these polymorphisms and tobacco smoking-related cancer sites remains unknown. Using epidemiological data and biological samples previously collected in three case-control studies from U.S. and Chinese populations, we selected and genotyped one SNP from each of the three previously determined “regions” within the 8q24 loci: rs1447295 (region 1), rs16901979 (region 2), and rs6983267 (region 3), and examined their association with cancers of the lung, oropharynx, nasopharynx, larynx, esophagus, stomach, liver, bladder, and kidney. We observed noteworthy associations between rs6983267 and upper aero-digestive tract (UADT) cancers (OR adj =1.69, 95% CI=1.28, 2.24), particularly in oropharynx (OR adj =1.80, 95% CI=1.30, 2.49) and larynx (OR adj =2.04, 95% CI=1.12, 3.72). We also observed a suggestive association between rs6983267 and liver cancer (OR adj =1.51, 95% CI=0.99, 2.31). When we stratified our analysis by smoking status, rs6983267 was positively associated with lung cancer among ever-smokers (OR adj =1.45, 95% CI=1.05, 2.00) and inversely associated with bladder cancer among ever-smokers (OR adj =0.35, 95% CI=0.14, 0.83). Associations were observed between rs16901979 and UADT cancer among never-smokers, and between rs1447295 and liver cancer among ever-smokers. Our results suggest variants of the 8q24 chromosome may play an important role in smoking-related cancer development. Functional and large epidemiological studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers.
Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24 SNPs have also been associated with colorectal cancer, suggesting that this region may not be specifically associated to just prostate cancer. To date, the association between these polymorphisms and tobacco smoking-related cancer sites remains unknown. Using epidemiologic data and biological samples previously collected in three case-control studies from U.S. and Chinese populations, we selected and genotyped one SNP from each of the three previously determined "regions" within the 8q24 loci, rs1447295 (region 1), rs16901979 (region 2), and rs6983267 (region 3), and examined their association with cancers of the lung, oropharynx, nasopharynx, larynx, esophagus, stomach, liver, bladder, and kidney. We observed noteworthy associations between rs6983267 and upper aerodigestive tract cancers [adjusted odds ratio (ORadj), 1.69; 95% confidence interval (95% CI), 1.28-2.24], particularly in oropharynx (ORadj, 1.80; 95% CI, 1.30-2.49) and larynx (ORadj, 2.04; 95% CI, 1.12-3.72). We also observed a suggestive association between rs6983267 and liver cancer (ORadj, 1.51; 95% CI, 0.99-2.31). When we stratified our analysis by smoking status, rs6983267 was positively associated with lung cancer among ever-smokers (ORadj, 1.45; 95% CI, 1.05-2.00) and inversely associated with bladder cancer among ever-smokers (ORadj, 0.35; 95% CI, 0.14-0.83). Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers. Our results suggest variants of the 8q24 chromosome may play an important role in smoking-related cancer development. Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers.Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24 SNPs have also been associated with colorectal cancer, suggesting that this region may not be specifically associated to just prostate cancer. To date, the association between these polymorphisms and tobacco smoking-related cancer sites remains unknown. Using epidemiologic data and biological samples previously collected in three case-control studies from U.S. and Chinese populations, we selected and genotyped one SNP from each of the three previously determined "regions" within the 8q24 loci, rs1447295 (region 1), rs16901979 (region 2), and rs6983267 (region 3), and examined their association with cancers of the lung, oropharynx, nasopharynx, larynx, esophagus, stomach, liver, bladder, and kidney. We observed noteworthy associations between rs6983267 and upper aerodigestive tract cancers [adjusted odds ratio (ORadj), 1.69; 95% confidence interval (95% CI), 1.28-2.24], particularly in oropharynx (ORadj, 1.80; 95% CI, 1.30-2.49) and larynx (ORadj, 2.04; 95% CI, 1.12-3.72). We also observed a suggestive association between rs6983267 and liver cancer (ORadj, 1.51; 95% CI, 0.99-2.31). When we stratified our analysis by smoking status, rs6983267 was positively associated with lung cancer among ever-smokers (ORadj, 1.45; 95% CI, 1.05-2.00) and inversely associated with bladder cancer among ever-smokers (ORadj, 0.35; 95% CI, 0.14-0.83). Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers. Our results suggest variants of the 8q24 chromosome may play an important role in smoking-related cancer development. Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers.
Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24 SNPs have also been associated with colorectal cancer, suggesting that this region may not be specifically associated to just prostate cancer. To date, the association between these polymorphisms and tobacco smoking-related cancer sites remains unknown. Using epidemiologic data and biological samples previously collected in three case-control studies from U.S. and Chinese populations, we selected and genotyped one SNP from each of the three previously determined “regions” within the 8q24 loci, rs1447295 (region 1), rs16901979 (region 2), and rs6983267 (region 3), and examined their association with cancers of the lung, oropharynx, nasopharynx, larynx, esophagus, stomach, liver, bladder, and kidney. We observed noteworthy associations between rs6983267 and upper aerodigestive tract cancers [adjusted odds ratio (OR adj ), 1.69; 95% confidence interval (95% CI), 1.28-2.24], particularly in oropharynx (OR adj , 1.80; 95% CI, 1.30-2.49) and larynx (OR adj , 2.04; 95% CI, 1.12-3.72). We also observed a suggestive association between rs6983267 and liver cancer (OR adj , 1.51; 95% CI, 0.99-2.31). When we stratified our analysis by smoking status, rs6983267 was positively associated with lung cancer among ever-smokers (OR adj , 1.45; 95% CI, 1.05-2.00) and inversely associated with bladder cancer among ever-smokers (OR adj , 0.35; 95% CI, 0.14-0.83). Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers. Our results suggest variants of the 8q24 chromosome may play an important role in smoking-related cancer development. Functional and large epidemiologic studies should be conducted to further investigate the association of 8q24 SNPs with smoking-related cancers. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3193–202)
Author Can-Qing Yu
Allan Pantuck
Simin Liu
Sander Greenland
Leslie J. Ng
Li-Na Mu
Arie Belldegrun
Jianyu Rao
Victor E. Reuter
Zuo-Feng Zhang
Carlos Cordon-Cardo
Shen-Chih Chang
Ming-Lan Lu
Jin-Kou Zhao
Bao-Guo Ding
Qingwu Jiang
Hal Morgenstern
Nai-Chieh Y. You
Lin Cai
Jenny T. Mao
Shun-Zhang Yu
Shehnaz K. Hussain
Donald P. Tashkin
Sungshim Lani Park
AuthorAffiliation 11 Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA
13 Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
5 Department of Statistics, UCLA, Los Angeles, CA, USA
6 Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA
4 Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China
8 Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY
12 Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
3 Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY
15 Gates Foundation Beijing Office, China
9 Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
2 Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China
7 Fudan University School of Public Health, Shanghai, China
10 Department of
AuthorAffiliation_xml – name: 3 Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY
– name: 4 Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China
– name: 9 Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
– name: 14 School of Public Health, Peking University, Beijing, China
– name: 11 Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA
– name: 1 Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA
– name: 7 Fudan University School of Public Health, Shanghai, China
– name: 2 Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China
– name: 10 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA
– name: 5 Department of Statistics, UCLA, Los Angeles, CA, USA
– name: 13 Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
– name: 8 Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY
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  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 3
  givenname: Lin
  surname: Cai
  fullname: Cai, Lin
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
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  givenname: Carlos
  surname: Cordon-Cardo
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  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 5
  givenname: Bao-Guo
  surname: Ding
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  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
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  givenname: Sander
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– sequence: 7
  givenname: Shehnaz K.
  surname: Hussain
  fullname: Hussain, Shehnaz K.
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 8
  givenname: Qingwu
  surname: Jiang
  fullname: Jiang, Qingwu
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 9
  givenname: Simin
  surname: Liu
  fullname: Liu, Simin
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
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  givenname: Ming-Lan
  surname: Lu
  fullname: Lu, Ming-Lan
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 11
  givenname: Jenny T.
  surname: Mao
  fullname: Mao, Jenny T.
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 12
  givenname: Hal
  surname: Morgenstern
  fullname: Morgenstern, Hal
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 13
  givenname: Li-Na
  surname: Mu
  fullname: Mu, Li-Na
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 14
  givenname: Leslie J.
  surname: Ng
  fullname: Ng, Leslie J.
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 15
  givenname: Allan
  surname: Pantuck
  fullname: Pantuck, Allan
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 16
  givenname: Jianyu
  surname: Rao
  fullname: Rao, Jianyu
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 17
  givenname: Victor E.
  surname: Reuter
  fullname: Reuter, Victor E.
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 18
  givenname: Donald P.
  surname: Tashkin
  fullname: Tashkin, Donald P.
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 19
  givenname: Nai-Chieh Y.
  surname: You
  fullname: You, Nai-Chieh Y.
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 20
  givenname: Can-Qing
  surname: Yu
  fullname: Yu, Can-Qing
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 21
  givenname: Shun-Zhang
  surname: Yu
  fullname: Yu, Shun-Zhang
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 22
  givenname: Jin-Kou
  surname: Zhao
  fullname: Zhao, Jin-Kou
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 23
  givenname: Arie
  surname: Belldegrun
  fullname: Belldegrun, Arie
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
– sequence: 24
  givenname: Zuo-Feng
  surname: Zhang
  fullname: Zhang, Zuo-Feng
  organization: Department of Epidemiology, University of California, Los Angeles (UCLA) School of Public Health, Los Angeles, CA, USA Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China Herbert Irwing Comprehensive Cancer Center, Columbia University, New York, NY Taixing City Center for Disease Prevention and Control (CDC), Taixing City, Jiangsu, China Department of Statistics, UCLA, Los Angeles, CA, USA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA USA Fudan University School of Public Health, Shanghai, China Departments of Pathology, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Social and Preventive Medicine, State University of New York (SUNY) at Buffalo, NY, USA Department of Urology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA Departments of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA School of Public Health, Peking University, Beijing, China Gates Foundation Beijing Office, China
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Snippet Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24...
Recent genome-wide association studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer. 8q24...
Recent genome-wide association (GWA) studies identified key single nucleotide polymorphisms (SNPs) in the 8q24 region to be associated with prostate cancer....
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StartPage 3193
SubjectTerms 8q24 polymorphisms
Adolescent
Adult
Aged
Alleles
bladder
Case-Control Studies
Chi-Square Distribution
Chromosomes, Human, Pair 8 - genetics
esophagus
Female
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
kidney
larynx
liver
Liver Neoplasms - ethnology
Liver Neoplasms - genetics
lung
Lung Neoplasms - ethnology
Lung Neoplasms - genetics
Male
Middle Aged
nasopharynx
neoplasms
Neoplasms - ethnology
Neoplasms - genetics
oropharynx
Otorhinolaryngologic Neoplasms - ethnology
Otorhinolaryngologic Neoplasms - genetics
Polymorphism, Single Nucleotide
Risk
Smoking - genetics
smoking-related cancers
SNP
stomach
Urinary Bladder Neoplasms - ethnology
Urinary Bladder Neoplasms - genetics
Title Associations between Variants of the 8q24 Chromosome and Nine Smoking-Related Cancer Sites
URI http://cebp.aacrjournals.org/content/17/11/3193.abstract
https://www.ncbi.nlm.nih.gov/pubmed/18990762
https://www.proquest.com/docview/69758151
https://pubmed.ncbi.nlm.nih.gov/PMC2664075
Volume 17
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