Ultrasensitive detection of malignant melanoma using PET molecular imaging probes

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 23; pp. 12991 - 12999
• Main Authors: Pyo, Ayoung, Kim, Dong-Yeon, Kim, Heejung, Lim, Daejin, Kwon, Seong Young, Kang, Sae-Ryung, Kim, Hyung-Seok, Bom, Hee-Seung, Min, Jung-Joon
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 09.06.2020
• Subjects: Benzamide; Biological Sciences; Diagnosis; Dosage; Fluorine isotopes; Image quality; Lymph nodes; Medical imaging; Melanoma; Metastases; Metastasis; Physical Sciences; Positron emission; Positron emission tomography; Pyridines; Radiochemistry; Retention; Skin cancer; Synthesis; Tomography; Tracers; Tumors; Xenografts; Xenotransplantation; malignant melanoma; molecular imaging; metastasis; 18F-labeled pyridine-based benzamide derivative; PET

Malignant melanoma has one of the highest mortality rates of any cancer because of its aggressive nature and high metastatic potential. Clinical staging of the disease at the time of diagnosis is very important for the prognosis and outcome of melanoma treatment. In this study, we designed and synth...