A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer

• Published in: Cancer letters Vol. 437; pp. 67 - 78
• Main Authors: Zhang, Hao, Zhang, Yanqiu, Chen, Chen, Zhu, Xiaoyun, Zhang, Chao, Xia, Yuanzheng, Zhao, Yucheng, Andrisani, Ourania M., Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.11.2018; Elsevier Limited
• Subjects: Binding sites; Breast cancer; Breast cancer metastasis; Cell culture; DDX21; DNA helicase; DNA methylation; EMT; Epigenetics; Feedback; Gene expression; Medical research; Mesenchyme; Metastases; Metastasis; miRNA; Polycomb group proteins; Proteins; Ribonucleic acid; RNA; RNA polymerase; Snail; Snail protein; Transcription; Transcription factors; Tumors; Beijing China; United States > US; China; DDX21; miRNA; Breast cancer metastasis; Snail; EMT

DDX21, a DEAD-box protein, implicated in fundamental aspects of RNA metabolism such as gene transcription. DDX21 expression is dysregulated in cancer, but its specific contribution to tumor invasion and metastasis remains to be determined. Here, we demonstrate DDX21 down-regulation is associated wit...