Structural and Kinetic Basis of Steroid 17α,20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2 - Pallan, Pradeep S.; Nagy, Leslie D.; Lei, Li; Gonzalez, Eric; Kramlinger, Valerie M.; Azumaya, Caleigh M.; Wawrzak, Zdzislaw; Waterman, Michael R.; Guengerich, F. Peter; Egli, Martin (The Journal of biological chemistry, 2015)
Keywords: Amino Acid Sequence; Androstenes - pharmacology; Animals; Catalytic Domain; Cytochrome P450; Enzyme Kinetics; Enzymology; Kinetics; Molecular Docking Simulation; Molecular Sequence Data; Pre-steady-state Kinetics; Progesterone - pharmacology; Protein Binding; Steroid 17-alpha-Hydroxylase - antagonists & inhibitors; Steroid 17-alpha-Hydroxylase - chemistry; Steroid 17-alpha-Hydroxylase - metabolism; Steroidogenesis; X-ray Crystallography; Zebrafish; Zebrafish Proteins - antagonists & inhibitors; Zebrafish Proteins - chemistry; Zebrafish Proteins - metabolism; Steroidogenesis; Enzyme Kinetics; Pre-steady-state Kinetics; X-ray Crystallography; Cytochrome P450