Proteoform-Specific Insights into Cellular Proteome Regulation

• Published in: Molecular & cellular proteomics Vol. 15; no. 10; pp. 3297 - 3320
• Main Authors: Norris, Emma L., Headlam, Madeleine J., Dave, Keyur A., Smith, David D., Bukreyev, Alexander, Singh, Toshna, Jayakody, Buddhika A., Chappell, Keith J., Collins, Peter L., Gorman, Jeffrey J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2016; The American Society for Biochemistry and Molecular Biology
• Subjects: A549 Cells - metabolism; A549 Cells - virology; Chromatography, Liquid - methods; Gene Expression Regulation; Humans; Phosphorylation; Proteolysis; Proteome - metabolism; Proteomics - methods; Respiratory Syncytial Virus, Human - physiology; Tandem Mass Spectrometry - methods; Technological Innovation and Resources

Knowledge regarding compositions of proteomes at the proteoform level enhances insights into cellular phenotypes. A strategy is described herein for discovery of proteoform-specific information about cellular proteomes. This strategy involved analysis of data obtained by bottom-up mass spectrometry...