Astrocytes Transplanted during Early Postnatal Development Integrate, Mature, and Survive Long Term in Mouse Cortex

• Published in: The Journal of neuroscience Vol. 43; no. 9; pp. 1509 - 1529
• Main Authors: Chierzi, Sabrina, Kacerovsky, J Benjamin, Fok, Albert H K, Lahaie, Sylvie, Shibi Rosen, Arielle, Farmer, W Todd, Murai, Keith K
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 01.03.2023
• Subjects: Animals; Aquaporin 4; Astrocytes; Astrocytes - metabolism; Brain; Calcium ions; Cerebellum; Cerebral Cortex; Circuits; Female; Male; Maturation; Mice; Microenvironments; Morphology; Neuroglia; Phenotypes; Physiology; Regenerative medicine; Survival; Tiling; Transplantation; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors; cortex; confocal imaging; diversity; astrocytes; transplantation

Astrocytes have complex structural, molecular, and physiological properties and form specialized microenvironments that support circuit-specific functions in the CNS. To better understand how astrocytes acquire their unique features, we transplanted immature mouse cortical astrocytes into the develo...