Estrogen Signaling as a Therapeutic Target in Neurodevelopmental Disorders

Estrogens, the primary female sex hormones, were originally characterized through their important role in sexual maturation and reproduction. However, recent studies have shown that estrogens play critical roles in a number of brain functions, including cognition, learning and memory, neurodevelopme...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of pharmacology and experimental therapeutics Vol. 360; no. 1; pp. 48 - 58
Main Authors Crider, Amanda, Pillai, Anilkumar
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2017
The American Society for Pharmacology and Experimental Therapeutics
Subjects
Animals
Brain - drug effects
Brain - physiopathology
Estrogens - metabolism
Humans
Minireviews
Molecular Targeted Therapy - methods
Neurodevelopmental Disorders - drug therapy
Neurodevelopmental Disorders - pathology
Neurodevelopmental Disorders - physiopathology
Signal Transduction - drug effects
CBP
FXS
ADHD
NF-κB
ASD
BPA
KO
BDNF
GPER
SERM
ER
Online AccessGet full text
ISSN0022-3565
1521-0103
1521-0103
DOI10.1124/jpet.116.237412

Cover

Abstract Estrogens, the primary female sex hormones, were originally characterized through their important role in sexual maturation and reproduction. However, recent studies have shown that estrogens play critical roles in a number of brain functions, including cognition, learning and memory, neurodevelopment, and adult neuroplasticity. A number of studies from both clinical as well as preclinical research suggest a protective role of estrogen in neurodevelopmental disorders including autism spectrum disorder (ASD) and schizophrenia. Alterations in the levels of estrogen receptors have been found in subjects with ASD or schizophrenia, and adjunctive estrogen therapy has been shown to be effective in enhancing the treatment of schizophrenia. This review summarizes the findings on the role of estrogen in the pathophysiology of neurodevelopmental disorders with a focus on ASD and schizophrenia. We also discuss the potential of estrogen as a therapeutic target in the above disorders.
AbstractList Estrogens, the primary female sex hormones, were originally characterized through their important role in sexual maturation and reproduction. However, recent studies have shown that estrogens play critical roles in a number of brain functions, including cognition, learning and memory, neurodevelopment, and adult neuroplasticity. A number of studies from both clinical as well as preclinical research suggest a protective role of estrogen in neurodevelopmental disorders including autism spectrum disorder (ASD) and schizophrenia. Alterations in the levels of estrogen receptors have been found in subjects with ASD or schizophrenia, and adjunctive estrogen therapy has been shown to be effective in enhancing the treatment of schizophrenia. This review summarizes the findings on the role of estrogen in the pathophysiology of neurodevelopmental disorders with a focus on ASD and schizophrenia. We also discuss the potential of estrogen as a therapeutic target in the above disorders.
Estrogens, the primary female sex hormones, were originally characterized through their important role in sexual maturation and reproduction. However, recent studies have shown that estrogens play critical roles in a number of brain functions, including cognition, learning and memory, neurodevelopment, and adult neuroplasticity. A number of studies from both clinical as well as preclinical research suggest a protective role of estrogen in neurodevelopmental disorders including autism spectrum disorder (ASD) and schizophrenia. Alterations in the levels of estrogen receptors have been found in subjects with ASD or schizophrenia, and adjunctive estrogen therapy has been shown to be effective in enhancing the treatment of schizophrenia. This review summarizes the findings on the role of estrogen in the pathophysiology of neurodevelopmental disorders with a focus on ASD and schizophrenia. We also discuss the potential of estrogen as a therapeutic target in the above disorders.Estrogens, the primary female sex hormones, were originally characterized through their important role in sexual maturation and reproduction. However, recent studies have shown that estrogens play critical roles in a number of brain functions, including cognition, learning and memory, neurodevelopment, and adult neuroplasticity. A number of studies from both clinical as well as preclinical research suggest a protective role of estrogen in neurodevelopmental disorders including autism spectrum disorder (ASD) and schizophrenia. Alterations in the levels of estrogen receptors have been found in subjects with ASD or schizophrenia, and adjunctive estrogen therapy has been shown to be effective in enhancing the treatment of schizophrenia. This review summarizes the findings on the role of estrogen in the pathophysiology of neurodevelopmental disorders with a focus on ASD and schizophrenia. We also discuss the potential of estrogen as a therapeutic target in the above disorders.
Author Crider, Amanda
Pillai, Anilkumar
Author_xml – sequence: 1
  givenname: Amanda
  surname: Crider
  fullname: Crider, Amanda
– sequence: 2
  givenname: Anilkumar
  surname: Pillai
  fullname: Pillai, Anilkumar
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27789681$$D View this record in MEDLINE/PubMed
BookMark eNp1UUtr3DAQFiWl2TzOvRUfe3GilyX7Uih5NizNIZuzkOWxo-CVXEle6L-vls2GNJDTDMz3GL7vCB047wChrwSfEUL5-fMEKW_ijDLJCf2EFqSipMQEswO0wJjSklWiOkRHMT5jTDgX7As6pFLWjajJAt1dxRT8AK54sIPTo3VDoWOhi9UTBD3BnKwpVjoMkArrit8wB9_BBkY_rcElPRaXNvrQQYgn6HOvxwinL_MYPV5frS5uy-X9za-Ln8vScM5S2Tad5LUk-d--aijGbYdFzRgTopa0rQTUvaBAKW9N1wtgQle0lYK1UlMiJTtGP3a609yuoTP5jaBHNQW71uGv8tqq_y_OPqnBb1RFGoYlywLfXwSC_zNDTGpto4Fx1A78HBWpc2YNYYRn6Le3Xq8m-wAzoNoBTPAxBuiVsUkn67fWdlQEq21RaltU3oTaFZV55-94e-mPGc2OATnbjYWgorHgDHQ2gEmq8_ZD7j_GzKl8
CitedBy_id crossref_primary_10_1038_s41467_021_21820_1
crossref_primary_10_3390_ijms22010373
crossref_primary_10_3390_women1010001
crossref_primary_10_1038_s41398_023_02357_x
crossref_primary_10_1016_j_bbi_2023_03_023
crossref_primary_10_1016_j_phymed_2019_153012
crossref_primary_10_3389_fphar_2020_590457
crossref_primary_10_1093_schizbullopen_sgaa062
crossref_primary_10_1016_j_biopsych_2022_09_033
crossref_primary_10_1007_s12035_018_0929_8
crossref_primary_10_1093_ijnp_pyx073
crossref_primary_10_3389_fpsyt_2020_579995
crossref_primary_10_3389_fpsyt_2021_630876
crossref_primary_10_1016_j_ecoenv_2023_114561
crossref_primary_10_1038_s41537_018_0044_x
crossref_primary_10_1186_s12964_020_00578_x
crossref_primary_10_1186_s12967_024_05973_3
crossref_primary_10_3390_ijms21093219
crossref_primary_10_3892_mmr_2020_10996
crossref_primary_10_3390_women2020015
crossref_primary_10_1016_j_pbb_2023_173630
crossref_primary_10_1007_s12020_016_1197_x
crossref_primary_10_1007_s11065_018_9372_x
crossref_primary_10_1093_toxsci_kfaa160
crossref_primary_10_1242_dev_199860
crossref_primary_10_1080_19490976_2023_2283911
crossref_primary_10_1097_MD_0000000000031787
crossref_primary_10_1111_bcpt_13576
crossref_primary_10_1016_j_neuroscience_2020_04_051
crossref_primary_10_1016_j_biopha_2019_109114
crossref_primary_10_1016_j_pnpbp_2025_111261
crossref_primary_10_1016_j_scitotenv_2024_174450
crossref_primary_10_1016_j_neuroscience_2023_10_009
crossref_primary_10_1016_j_yhbeh_2020_104848
crossref_primary_10_1016_j_yhbeh_2019_104637
crossref_primary_10_1002_aur_2177
crossref_primary_10_1007_s12035_022_02878_4
crossref_primary_10_3389_fmicb_2022_821311
crossref_primary_10_3174_ajnr_A6601
crossref_primary_10_2147_DDDT_S249608
crossref_primary_10_1016_j_psyneuen_2021_105165
crossref_primary_10_1007_s12038_022_00308_0
crossref_primary_10_1155_2019_6869350
crossref_primary_10_3389_fped_2021_729198
crossref_primary_10_1016_j_lfs_2023_121860
crossref_primary_10_1007_s12035_024_04312_3
crossref_primary_10_3390_ijms21093316
crossref_primary_10_3389_fendo_2023_1240018
crossref_primary_10_1016_j_envpol_2022_120956
crossref_primary_10_1016_j_jtemb_2020_126638
crossref_primary_10_3389_fendo_2021_701364
crossref_primary_10_1016_j_euroneuro_2021_03_016
crossref_primary_10_3389_fendo_2024_1472908
crossref_primary_10_3390_jcm13072106
Cites_doi 10.1016/0306-4530(90)90018-5
10.1016/j.psyneuen.2011.03.016
10.1016/S0022-5347(05)00049-2
10.1523/JNEUROSCI.4333-09.2010
10.1046/j.1471-4159.1995.65041651.x
10.1016/j.brainresrev.2007.05.013
10.1126/science.3753802
10.1016/j.psyneuen.2014.02.004
10.1176/ajp.154.11.1626-a
10.1016/j.psyneuen.2006.11.002
10.1073/pnas.0704757104
10.1523/JNEUROSCI.16-21-07021.1996
10.1523/JNEUROSCI.5186-03.2004
10.1016/j.jsbmb.2014.05.001
10.1074/jbc.M114.566893
10.1016/j.yhbeh.2005.08.010
10.1523/JNEUROSCI.10-12-04035.1990
10.2165/11630660-000000000-00000
10.1038/onc.2014.343
10.1080/j.1440-1614.2000.00728.x
10.1210/er.2011-0004
10.1111/j.1365-2265.2012.04443.x
10.1016/j.nlm.2005.10.003
10.1074/jbc.M112.412478
10.1016/j.brainres.2008.02.061
10.1016/j.jsbmb.2013.09.018
10.1016/S0301-0082(00)00059-9
10.1016/j.biopsych.2005.04.047
10.1196/annals.1286.006
10.1212/WNL.57.8.1519
10.1523/JNEUROSCI.1298-14.2015
10.5812/ijem.6615
10.1056/NEJMra000471
10.1097/JCP.0000000000000492
10.1172/JCI11066
10.1016/j.euroneuro.2013.11.012
10.1523/JNEUROSCI.3264-10.2010
10.1016/j.pnpbp.2008.04.017
10.1097/01.jcp.0000237942.50270.35
10.1016/j.cell.2009.07.036
10.1111/j.1751-7893.2007.00026.x
10.1146/annurev.neuro.25.112701.142754
10.1073/pnas.012032699
10.1016/S0306-4530(01)00054-3
10.1034/j.1399-5618.1999.010204.x
10.1016/j.euroneuro.2005.07.007
10.1002/hipo.20173
10.1371/journal.pbio.1001081
10.1111/j.1600-0447.2001.00288.x
10.1016/j.addr.2008.06.003
10.1016/j.tem.2005.01.004
10.1093/jnci/86.7.527
10.1210/endo.141.10.7693
10.1159/000088448
10.1016/j.schres.2009.07.002
10.1186/1866-1955-6-26
10.1093/hmg/ddn130
10.1160/TH07-07-0468
10.1016/j.brainres.2014.12.056
10.1007/s00213-009-1464-0
10.1523/JNEUROSCI.3059-09.2009
10.1016/j.neuroscience.2011.02.012
10.1038/sj.npp.1300956
10.1002/cne.10989
10.1523/JNEUROSCI.3135-15.2016
10.1523/JNEUROSCI.1968-08.2008
10.1016/S0006-8993(99)01452-3
10.1016/j.molmed.2012.12.007
10.1126/science.1068537
10.1002/0470870818.ch10
10.1016/j.bbagen.2010.06.002
10.1002/aur.80
10.1073/pnas.221451898
10.1016/j.jchemneu.2016.05.005
10.1677/JOE-09-0242
10.1073/pnas.0801581105
10.1177/1534582305277152
10.1016/j.envres.2015.07.024
10.1186/2040-2392-5-46
10.1016/S0193-953X(03)00036-4
10.1523/JNEUROSCI.10-04-01286.1990
10.1016/S0140-6736(95)91386-6
10.1016/j.brainres.2004.12.014
10.1006/hbeh.1997.1433
10.1111/j.1749-6632.2010.05529.x
10.1002/ana.24358
10.1196/annals.1347.005
10.1016/S0166-2236(96)01035-1
10.1007/s00213-015-3935-9
10.1176/appi.ajp.159.7.1225
10.1097/00001756-200310270-00020
10.1002/(SICI)1096-9861(19971208)389:1<81::AID-CNE6>3.0.CO;2-A
10.1523/JNEUROSCI.22-07-02650.2002
10.1210/en.2012-1061
10.1210/en.2014-1734
10.1530/EJE-10-1038
10.1016/j.neurobiolaging.2011.03.001
10.1210/en.2011-1925
10.1038/nrendo.2009.193
10.2165/00003495-200464200-00003
10.1210/en.2007-1645
10.1192/bjp.150.5.662
10.1073/pnas.97.7.3602
10.1016/j.yhbeh.2008.02.001
10.1038/mp.2014.33
10.1016/j.neuroscience.2005.11.054
10.1002/glia.20805
10.1016/S0140-6736(94)92466-X
10.1002/ana.20275
10.1074/jbc.M111.224071
10.1038/mp.2013.83
10.1177/070674370204700504
10.1038/nn2057
10.1016/j.psyneuen.2010.02.007
10.1124/pr.114.009712
10.1016/j.yhbeh.2007.05.011
10.1016/j.steroids.2007.02.003
10.1016/S0306-4530(98)00068-7
10.1016/S0165-5728(00)00386-6
10.1016/S0278-5846(03)00161-1
10.1016/j.neurobiolaging.2009.11.002
10.1038/320134a0
10.1038/npp.2015.88
10.1523/JNEUROSCI.21-06-01809.2001
10.1348/000712608X311731
10.1016/j.neuroscience.2010.04.030
10.1001/jamapsychiatry.2016.1383
10.1016/B978-0-12-411546-0.00009-3
10.1016/0304-3940(94)90510-X
10.1001/archgenpsychiatry.2007.43
10.1289/ehp.1104492
10.1016/j.biopsych.2005.10.019
10.1080/00048670701732699
10.1159/000065951
10.1093/schbul/20.1.203
10.1016/j.jchemneu.2011.02.002
10.1111/jne.12034
10.1007/BF02088176
10.1126/science.1106943
10.1016/0006-8993(94)91694-2
10.1016/j.neuroscience.2005.03.056
10.1176/appi.ajp.159.5.713
10.1016/j.expneurol.2006.07.020
10.1016/j.amjmed.2009.01.033
10.1159/000093780
10.1016/j.jsbmb.2004.02.004
10.1067/mjd.2001.117432
10.1016/S0893-133X(00)00085-3
10.1152/physrev.00010.2007
10.3389/fnbeh.2013.00136
10.1093/schbul/sbr070
10.1016/j.yfrne.2011.10.001
10.1007/s12264-010-0913-4
10.1016/S0079-6123(08)81012-6
10.1210/en.2010-0371
10.4331/wjbc.v1.i5.133
10.1371/journal.pone.0009851
10.1186/2040-2392-3-17
10.1016/S0006-3223(99)00156-0
10.1073/pnas.93.12.5925
10.1097/YPG.0b013e328351850b
10.1046/j.1471-4159.1999.0731453.x
10.1093/schbul/sbm138
10.1523/JNEUROSCI.19-15-06385.1999
10.1016/j.tem.2005.08.005
10.1016/j.schres.2010.09.014
10.1001/jama.281.23.2189
10.1176/appi.ajp.158.7.1134
10.1016/S1016-8478(23)13962-8
10.1016/j.yfrne.2006.02.004
10.1038/nrn846
10.1016/j.neuroscience.2009.09.011
10.1038/sj.embor.7400444
10.1073/pnas.1531957100
10.1155/2015/615356
10.1186/2040-2392-6-7
10.1161/hh2101.098543
10.1093/epirev/mxn001
10.1016/j.physbeh.2014.09.014
10.1006/hbeh.1998.1473
10.1016/0304-3940(90)90618-J
10.1002/aur.191
10.1017/S0033291707000578
10.1038/mp.2015.11
10.1016/j.yfrne.2007.08.002
10.1016/j.tins.2006.03.004
10.1523/JNEUROSCI.2588-07.2007
10.1111/j.1472-8206.2004.00284.x
ContentType Journal Article
Copyright 2016 American Society for Pharmacology and Experimental Therapeutics
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics 2017
Copyright_xml – notice: 2016 American Society for Pharmacology and Experimental Therapeutics
– notice: Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.
– notice: Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics 2017
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1124/jpet.116.237412
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
DocumentTitleAlternate Estrogen Signaling, ASD, and Schizophrenia
EISSN 1521-0103
EndPage 58
ExternalDocumentID PMC5193073
27789681
10_1124_jpet_116_237412
S0022356524194669
Genre Journal Article
Review
GrantInformation_xml – fundername: NIMH NIH HHS
  grantid: R01 MH097060
GroupedDBID ---
-~X
.55
.GJ
0R~
18M
2WC
3O-
4.4
53G
5GY
5RE
5VS
8WZ
A6W
AAJMC
AALRI
AAXUO
AAYOK
ABCQX
ABIVO
ABJNI
ABOCM
ABSQV
ACGFO
ACGFS
ACNCT
ADBBV
ADCOW
ADIYS
AENEX
AERNN
AFFNX
AFHIN
AFOSN
AGFXO
AI.
ALMA_UNASSIGNED_HOLDINGS
BAWUL
BTFSW
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
F9R
FDB
GX1
H13
HZ~
INIJC
KQ8
L7B
LSO
M41
MJL
MVM
O9-
OHT
OK1
P2P
PKN
R.V
R0Z
RHF
RHI
ROL
RPT
TR2
UQL
VH1
W2D
W8F
WH7
WOQ
X7M
YBU
YHG
YQT
ZGI
ZXP
AAYXX
ACVFH
ADCNI
AETEA
AEUPX
AFPUW
AIGII
AKBMS
AKYEP
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
ID FETCH-LOGICAL-c443t-b9d74871741f59200bd06833366872b56e8f62e224bcdf6e36a52b763b7a21773
ISSN 0022-3565
1521-0103
IngestDate Thu Aug 21 18:24:24 EDT 2025
Fri Jul 11 09:37:53 EDT 2025
Sat Mar 08 01:25:23 EST 2025
Tue Jul 01 05:40:00 EDT 2025
Thu Apr 24 23:03:56 EDT 2025
Sat Feb 15 15:51:29 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords CBP
FXS
ADHD
NF-κB
ASD
BPA
KO
BDNF
GPER
SERM
ER
Language English
License Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c443t-b9d74871741f59200bd06833366872b56e8f62e224bcdf6e36a52b763b7a21773
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink https://jpet.aspetjournals.org/content/jpet/360/1/48.full.pdf
PMID 27789681
PQID 1835691314
PQPubID 23479
PageCount 11
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5193073
proquest_miscellaneous_1835691314
pubmed_primary_27789681
crossref_citationtrail_10_1124_jpet_116_237412
crossref_primary_10_1124_jpet_116_237412
elsevier_sciencedirect_doi_10_1124_jpet_116_237412
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate January 2017
2017-01-00
2017-Jan
20170101
PublicationDateYYYYMMDD 2017-01-01
PublicationDate_xml – month: 01
  year: 2017
  text: January 2017
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Bethesda, MD
PublicationTitle The Journal of pharmacology and experimental therapeutics
PublicationTitleAlternate J Pharmacol Exp Ther
PublicationYear 2017
Publisher Elsevier Inc
The American Society for Pharmacology and Experimental Therapeutics
Publisher_xml – name: Elsevier Inc
– name: The American Society for Pharmacology and Experimental Therapeutics
References Kuiper, Enmark, Pelto-Huikko, Nilsson, Gustafsson (bib101) 1996; 93
Cheng, Quinn, Graeber, Filardo (bib45) 2011; 286
Filardo, Thomas (bib64) 2012; 153
Rissman, Wersinger, Fugger, Foster (bib148) 1999; 835
Bodo, Rissman (bib32) 2006; 27
Kulkarni, Gavrilidis, Worsley, Van Rheenen, Hayes (bib106) 2013; 11
Dodel, Du, Bales, Gao, Paul (bib54) 1999; 73
Palomba, Marotta, Di Cello, Russo, Falbo, Orio, Tolino, Zullo, Esposito, La Sala (bib133) 2012; 77
McCarthy (bib119) 2008; 88
Bossé, DiPaolo (bib34) 1996; 16
Srivastava, Woolfrey, Jones, Shum, Lash, Swanson, Penzes (bib172) 2008; 105
Auyeung, Baron-Cohen, Ashwin, Knickmeyer, Taylor, Hackett (bib13) 2009; 100
Evans, Eckert, Lai, Adelman, Harnish (bib59) 2001; 89
Fan, Zhao, Orr, Chambers, Lewis, Frick (bib61) 2010; 30
Weickert, Miranda-Angulo, Wong, Perlman, Ward, Radhakrishna, Straub, Weinberger, Kleinman (bib186) 2008; 17
Mendrek, Lakis, Jiménez (bib121) 2011; 36
Österlund, Hurd (bib131) 2001; 64
Wu, Manoli, Fraser, Coats, Tollkuhn, Honda, Harada, Shah (bib194) 2009; 139
Andreescu, Milojkovic, Haasdijk, Kramer, De Jong, Krust, De Zeeuw, De Jeu (bib8) 2007; 27
Choi, Lee, Hong, Lee (bib46) 2004; 18
Krezel, Dupont, Krust, Chambon, Chapman (bib100) 2001; 98
O’Neill, Kaltschmidt (bib130) 1997; 20
Hao, Rapp, Janssen, Lou, Lasley, Hof, Morrison (bib79) 2007; 104
Hoff, Kremen, Wieneke, Lauriello, Blankfeld, Faustman, Csernansky, Nordahl (bib83) 2001; 158
Martino, Macerollo, Leckman (bib118) 2013; 112
Xiao, Becker (bib195) 1994; 180
Meitzen, Mermelstein (bib210) 2011; 42
Almey, Hafez, Hantson, Brake (bib5) 2013; 7
Kulkarni, Gavrilidis, Worsley, Hayes (bib105) 2012; 26
Arad, Weiner (bib9) 2009; 206
Riecher-Rössler, Häfner, Stumbaum, Maurer, Schmidt (bib146) 1994; 20
Bimonte, Denenberg (bib30) 1999; 24
Piriu, Torac, Gaman, Iosif, Tivig, Delia, Gilca, Stoian, Atanasiu (bib140) 2015; 8
Amin, Canli, Epperson (bib7) 2005; 4
Filardo, Thomas (bib63) 2005; 16
Balthazart, Ball (bib16) 2006; 29
Yague, Wang, Janssen, Hof, Garcia-Segura, Azcoitia, Morrison (bib198) 2008; 1209
Weinberger (bib188) 1995; 346
Cui, Shen, Li (bib50) 2013; 19
Waters, Thompson, Patel, Gonzales, Ye, Filardo, Clegg, Gorecka, Akama, McEwen (bib184) 2015; 35
Cotton, Lambert, Schimmelmann, Foley, Morley, McGorry, Conus (bib48) 2009; 114
Sherman, Curnow, Easley, Jin, Hukema, Tejada, Willemsen, Usdin (bib165) 2014; 6
Frye, Rhodes, Dudek (bib66) 2005; 1036
Miodovnik, Diplas, Chen, Zhu, Engel, Wolff (bib124) 2012; 22
Kedar, Bourne, Powles, Collins, Ashley, Cosgrove, Campbell (bib91) 1994; 343
Asscheman, Giltay, Megens, de Ronde, van Trotsenburg, Gooren (bib11) 2011; 164
Akama, Thompson, Milner, McEwen (bib3) 2013; 288
Wei, Yuen, Liu, Li, Zhong, Karatsoreos, McEwen, Yan (bib185) 2014; 19
Revankar, Cimino, Sklar, Arterburn, Prossnitz (bib144) 2005; 307
Simpson, Zhao, Agarwal, Michael, Bulun, Hinshelwood, Graham-Lorence, Sun, Fisher, Qin (bib169) 1997; 52
Brinton (bib36) 2005; 1052
Nelson, Bulun (bib127) 2001; 45
Shang, Zhao, Cao, Xue (bib164) 2010; 26
(bib6) 2013
Bebo, Dehghani, Foster, Kurniawan, Lopez, Sherman (bib19) 2009; 57
Solum, Handa (bib171) 2002; 22
Casas, Forns, Martínez, Avella-García, Valvi, Ballesteros-Gómez, Luque, Rubio, Julvez, Sunyer (bib41) 2015; 142
Srivastava, Woolfrey, Liu, Brandon, Penzes (bib173) 2010; 30
Daniel, Fader, Spencer, Dohanich (bib52) 1997; 32
Baron-Cohen, Lombardo, Auyeung, Ashwin, Chakrabarti, Knickmeyer (bib17) 2011; 9
Conus, Cotton, Schimmelmann, McGorry, Lambert (bib47) 2007; 1
Sánchez, Morissette, Di Paolo (bib157) 2013; 25
Sherwin (bib168) 2009; 5
Bergemann, Parzer, Runnebaum, Resch, Mundt (bib26) 2007; 37
Dubal, Zhu, Yu, Rau, Shughrue, Merchenthaler, Kindy, Wise (bib56) 2001; 98
Gruber, Tschugguel, Schneeberger, Huber (bib75) 2002; 346
Roybal, Singh, Cosgrove, Howe, Kelley, Barnea-Goraly, Chang (bib152) 2012; 49
Mahé, Dumaine (bib116) 2001; 104
Morgan, Castle, Jablensky (bib125) 2008; 42
Prange-Kiel, Fester, Zhou, Lauke, Carrétero, Rune (bib141) 2006; 16
Weickert, Weinberg, Lenroot, Catts, Wells, Vercammen, O’Donnell, Galletly, Liu, Balzan (bib187) 2015; 20
Kulkarni, Gavrilidis, Wang, Worsley, Fitzgerald, Gurvich, Van Rheenen, Berk, Burger (bib104) 2015; 20
Chang, Renshaw (bib44) 1986; 12
Zhou, Zhang, Cohen, Pandey (bib206) 2005; 81
Gould, Woolley, Frankfurt, McEwen (bib72) 1990; 10
Ostlund, Keller, Hurd (bib132) 2003; 1007
Kooptiwut, Mahawong, Hanchang, Semprasert, Kaewin, Limjindaporn, Yenchitsomanus (bib97) 2014; 139
Lee, Park, Kim (bib111) 2008; 26
Hahn, Friedman (bib77) 1999; 1
Woolley, Gould, Frankfurt, McEwen (bib193) 1990; 10
Sherwin, Henry (bib167) 2008; 29
Dubal, Shughrue, Wilson, Merchenthaler, Wise (bib57) 1999; 19
Weiser, Foradori, Handa (bib189) 2008; 57
Kompoliti, Goetz, Leurgans, Raman, Comella (bib96) 2001; 57
Tordjman, Ferrari, Sulmont, Duyme, Roubertoux (bib179) 1997; 154
Cummings, Eckert, Krueger, Grady, Powles, Cauley, Norton, Nickelsen, Bjarnason, Morrow, Lippman, Black, Glusman, Costa, Jordan (bib209) 1999; 281
Kyomen, Satlin, Hennen, Wei (bib107) 1999; 7
Yokosuka, Okamura, Hayashi (bib205) 1997; 389
Ritsner, Gibel, Ratner, Tsinovoy, Strous (bib150) 2006; 26
Perlman, Tomaskovic-Crook, Montague, Webster, Rubinow, Kleinman, Weickert (bib137) 2005; 58
Yague, Muñoz, de Monasterio-Schrader, Defelipe, Garcia-Segura, Azcoitia (bib197) 2006; 138
Cyr, Landry, Di Paolo (bib51) 2000; 23
Brann, Dhandapani, Wakade, Mahesh, Khan (bib35) 2007; 72
Huang, Yin, Li, Li, Qi, Fang, Yuan, Liu, Wang, Li (bib86) 2016; 9
Broselid, Berg, Chavera, Kahn, Clarke, Olde, Leeb-Lundberg (bib38) 2014; 289
Kulkarni, Berk, Wang, Mu, Scarr, Van Rheenen, Worsley, Gurvich, Gavrilidis, de Castella (bib102) 2014; 43
Beer, Bland, Bussiere, Neiss, Wersinger, Garzotto, Ryan, Janowsky (bib22) 2006; 175
Bethea, Mirkes, Su, Michelson (bib28) 2002; 27
Pasqualini, Olivier, Guibert, Frain, Leviel (bib134) 1995; 65
Kyomen, Hennen, Gottlieb, Wei (bib108) 2002; 159
Hu, Sarachana, Sherrard, Kocher (bib85) 2015; 6
De Fossé, Hodge, Makris, Kennedy, Caviness, McGrath, Steele, Ziegler, Herbert, Frazier (bib53) 2004; 56
Gogos, Sbisa, Sun, Gibbons, Udawela, Dean (bib71) 2015; 2015
Kalaitzidis, Gilmore (bib89) 2005; 16
Zhou, Lehan, Wehrenberg, Disteldorf, von Lossow, Mares, Jarry, Rune (bib207) 2007; 203
Ko, Joe, Cho, Park, Lee, Jung, Kim, Kim (bib95) 2006; 53
Blurton-Jones, Kuan, Tuszynski (bib31) 2004; 468
Pfaff, Rapin, Goldman (bib138) 2011; 4
Talaei, Pourgholami, Khatibi-Moghadam, Faridhosseini, Farhoudi, Askari-Noghani, Sadeghi (bib177) 2016; 36
Hoftman GD, Datta D, Lewis DA (2016) Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia.
Pierman, Sica, Allieri, Viglietti-Panzica, Panzica, Bakker (bib139) 2008; 54
Rhodes, Frye (bib145) 2006; 85
Knickmeyer, Baron-Cohen, Raggatt, Taylor, Hackett (bib94) 2006; 49
Lewis, Levitt (bib112) 2002; 25
Bi, Broutman, Foy, Thompson, Baudry (bib29) 2000; 97
Kretz, Fester, Wehrenberg, Zhou, Brauckmann, Zhao, Prange-Kiel, Naumann, Jarry, Frotscher (bib99) 2004; 24
Shang, Brown (bib163) 2002; 295
Auyeung, Ahluwalia, Thomson, Taylor, Hackett, O’Donnell, Baron-Cohen (bib12) 2012; 3
Kramár, Chen, Brandon, Rex, Liu, Gall, Lynch (bib98) 2009; 29
Singh, Meyer, Millard, Simpkins (bib170) 1994; 644
Rissman, Heck, Leonard, Shupnik, Gustafsson (bib147) 2002; 99
McGrath, Saha, Chant, Welham (bib120) 2008; 30
Tuscher, Luine, Frankfurt, Frick (bib180) 2016; 36
Kulkarni, Gavrilidis, Gwini, Worsley, Grigg, Warren, Gurvich, Gilbert, Berk, Davis (bib103) 2016; 73
Rubin, Carter, Drogos, Pournajafi-Nazarloo, Sweeney, Maki (bib153) 2010; 124
Haddad, Wieck (bib76) 2004; 64
Cenci, Weitzmann, Roggia, Namba, Novack, Woodring, Pacifici (bib42) 2000; 106
Sanches, Keshavan, Brambilla, Soares (bib156) 2008; 32
Fernandez, Lewis, Pechenino, Harburger, Orr, Gresack, Schafe, Frick (bib62) 2008; 28
Milad, Igoe, Lebron-Milad, Novales (bib122) 2009; 164
Chakrabarti, Dudbridge, Kent, Wheelwright, Hill-Cawthorne, Allison, Banerjee-Basu, Baron-Cohen (bib43) 2009; 2
Tata (bib178) 2005; 6
Gibbs, Johnson (bib68) 2008; 149
Whitehouse, Maybery, Hart, Mattes, Newnham, Sloboda, Stanley, Hickey (bib190) 2010; 35
Vegeto, Ghisletti, Meda, Etteri, Belcredito, Maggi (bib183) 2004; 91
Pecins-Thompson, Brown, Kohama, Bethea (bib135) 1996; 16
Adomaityte, Farooq, Qayyum (bib2) 2008; 99
Yang, Yang, Zhang, Guo, Liu, Wu, Li, Song, Zhuo, Zhao (bib199) 2015; 77
Hampson (bib78) 1990; 15
Fallah, Arman, Najafi, Shayegh (bib60) 2016; 10
O’Brian, Liskamp, Solomon, Weinstein (bib129) 1986; 76
Yang, Zhang, Zhou, Yang, Zhang, Wang, Brann (bib200) 2010; 5
Boon, Chow, Simpson (bib33) 2010; 181
Maggiolini, Picard (bib115) 2010; 204
Milad, Zeidan, Contero, Pitman, Klibanski, Rauch, Goldstein (bib123) 2010; 168
Sherwin, Chertkow, Schipper, Nasreddine (bib166) 2011; 32
Bergemann, Parzer, Jaggy, Auler, Mundt, Maier-Braunleder (bib25) 2008; 34
Scott, Zhang, Wang, Vadlamudi, Brann (bib161) 2012; 33
Hasegawa, Hojo, Kojima, Ikeda, Hotta, Sato, Ooishi, Yoshiya, Chung, Yamazaki (bib80) 2015; 1621
Wong, Rothmond, Webster, Weickert (bib192) 2013; 39
Jablensky, McGrath, Herrman, Castle, Gureje, Evans, Carr, Morgan, Korten, Harvey (bib88) 2000; 34
Bruce-Keller, Keeling, Keller, Huang, Camondola, Mattson (bib40) 2000; 141
Stevens (bib175) 2002; 159
Becker (bib21) 2000; 230
Schug, Blawas, Gray, Heindel, Lawler (bib160) 2015; 156
Azcoitia, Yague, Garcia-Segura (bib15) 2011; 191
Kindler, Weickert, Skilleter, Catts, Lenroot, Weickert (bib93) 2015; 40
Behl (bib23) 2002; 3
Labouesse, Langhans, Meyer (bib109) 2015; 232
Perera, Vishnevetsky, Herbstman, Calafat, Xiong, Rauh, Wang (bib136) 2012; 120
Akhondzadeh, Nejatisafa, Amini, Mohammadi, Larijani, Kashani, Raisi, Kamalipour (bib4) 2003; 27
Green, Walter, Kumar, Krust, Bornert, Argos, Chambon (bib73) 1986; 320
Brinton (bib37) 2008; 60
Martin, Jones, Simpson, van den Buuse (bib117) 2003; 14
Numakawa, Yokomaku, Richards, Hori, Adachi, Kunugi (bib128) 2010; 1
Barrett-Connor, Cox, Song, Mitlak, Mosca, Grady (bib18) 2009; 122
Bethea, Mirkes, Shively, Adams (bib27) 2000; 47
Fisher, Costantino, Redmond, Fisher, Wickerham, Cronin (bib65) 1994; 86
S0006-3223(16)32427-1 10.1016/j.biopsych.2016.05.022.
Vegeto, Belcredito, Ett
Filardo (10.1124/jpet.116.237412_bib63) 2005; 16
Ostlund (10.1124/jpet.116.237412_bib132) 2003; 1007
Becker (10.1124/jpet.116.237412_bib20) 1990; 118
Crider (10.1124/jpet.116.237412_bib49) 2014; 5
Mahé (10.1124/jpet.116.237412_bib116) 2001; 104
O’Brian (10.1124/jpet.116.237412_bib129) 1986; 76
O’Neill (10.1124/jpet.116.237412_bib130) 1997; 20
Perera (10.1124/jpet.116.237412_bib136) 2012; 120
Boon (10.1124/jpet.116.237412_bib33) 2010; 181
Milad (10.1124/jpet.116.237412_bib123) 2010; 168
Cotton (10.1124/jpet.116.237412_bib48) 2009; 114
Bergemann (10.1124/jpet.116.237412_bib25) 2008; 34
Hiroi (10.1124/jpet.116.237412_bib82) 2006; 60
Fernandez (10.1124/jpet.116.237412_bib62) 2008; 28
Bi (10.1124/jpet.116.237412_bib29) 2000; 97
Vegeto (10.1124/jpet.116.237412_bib182) 2001; 21
Martin (10.1124/jpet.116.237412_bib117) 2003; 14
Huerta-Ramos (10.1124/jpet.116.237412_bib87) 2014; 24
Numakawa (10.1124/jpet.116.237412_bib128) 2010; 1
10.1124/jpet.116.237412_bib84
Auyeung (10.1124/jpet.116.237412_bib12) 2012; 3
Liu (10.1124/jpet.116.237412_bib113) 2008; 11
Greene (10.1124/jpet.116.237412_bib74) 1986; 231
Brinton (10.1124/jpet.116.237412_bib36) 2005; 1052
Nelson (10.1124/jpet.116.237412_bib127) 2001; 45
Singh (10.1124/jpet.116.237412_bib170) 1994; 644
Weickert (10.1124/jpet.116.237412_bib187) 2015; 20
Scott (10.1124/jpet.116.237412_bib161) 2012; 33
(10.1124/jpet.116.237412_bib6) 2013
Weiser (10.1124/jpet.116.237412_bib189) 2008; 57
Chakrabarti (10.1124/jpet.116.237412_bib43) 2009; 2
Talaei (10.1124/jpet.116.237412_bib177) 2016; 36
McGrath (10.1124/jpet.116.237412_bib120) 2008; 30
Rune (10.1124/jpet.116.237412_bib154) 2005; 136
Auyeung (10.1124/jpet.116.237412_bib13) 2009; 100
Casas (10.1124/jpet.116.237412_bib41) 2015; 142
Gibbs (10.1124/jpet.116.237412_bib67) 2007; 52
Kendell (10.1124/jpet.116.237412_bib90) 1987; 150
Green (10.1124/jpet.116.237412_bib73) 1986; 320
Cenci (10.1124/jpet.116.237412_bib42) 2000; 106
Vegeto (10.1124/jpet.116.237412_bib181) 2003; 100
Behl (10.1124/jpet.116.237412_bib23) 2002; 3
Kulkarni (10.1124/jpet.116.237412_bib105) 2012; 26
Wong (10.1124/jpet.116.237412_bib192) 2013; 39
Beer (10.1124/jpet.116.237412_bib22) 2006; 175
Kulkarni (10.1124/jpet.116.237412_bib104) 2015; 20
Almey (10.1124/jpet.116.237412_bib5) 2013; 7
Goekoop (10.1124/jpet.116.237412_bib69) 2006; 31
Hasegawa (10.1124/jpet.116.237412_bib80) 2015; 1621
Sánchez (10.1124/jpet.116.237412_bib157) 2013; 25
Sherwin (10.1124/jpet.116.237412_bib168) 2009; 5
Lewis (10.1124/jpet.116.237412_bib112) 2002; 25
Pecins-Thompson (10.1124/jpet.116.237412_bib135) 1996; 16
Bethea (10.1124/jpet.116.237412_bib28) 2002; 27
Ko (10.1124/jpet.116.237412_bib95) 2006; 53
Balthazart (10.1124/jpet.116.237412_bib16) 2006; 29
Brinton (10.1124/jpet.116.237412_bib37) 2008; 60
Landry (10.1124/jpet.116.237412_bib110) 2002; 76
Tuscher (10.1124/jpet.116.237412_bib180) 2016; 36
Sherwin (10.1124/jpet.116.237412_bib166) 2011; 32
Piriu (10.1124/jpet.116.237412_bib140) 2015; 8
Fan (10.1124/jpet.116.237412_bib61) 2010; 30
Maggiolini (10.1124/jpet.116.237412_bib115) 2010; 204
Zhou (10.1124/jpet.116.237412_bib206) 2005; 81
Simpson (10.1124/jpet.116.237412_bib169) 1997; 52
Weickert (10.1124/jpet.116.237412_bib186) 2008; 17
Cummings (10.1124/jpet.116.237412_bib209) 1999; 281
Gogos (10.1124/jpet.116.237412_bib71) 2015; 2015
Mendrek (10.1124/jpet.116.237412_bib121) 2011; 36
Khan (10.1124/jpet.116.237412_bib92) 2015; 146
Hampson (10.1124/jpet.116.237412_bib78) 1990; 15
McCarthy (10.1124/jpet.116.237412_bib119) 2008; 88
Rajapaksa (10.1124/jpet.116.237412_bib143) 2015; 34
Fallah (10.1124/jpet.116.237412_bib60) 2016; 10
Labouesse (10.1124/jpet.116.237412_bib109) 2015; 232
Azcoitia (10.1124/jpet.116.237412_bib15) 2011; 191
Cyr (10.1124/jpet.116.237412_bib51) 2000; 23
Grigoriadis (10.1124/jpet.116.237412_bib208) 2002; 47
Morgan (10.1124/jpet.116.237412_bib125) 2008; 42
Xiao (10.1124/jpet.116.237412_bib195) 1994; 180
Yi (10.1124/jpet.116.237412_bib203) 2016; 77
Chang (10.1124/jpet.116.237412_bib44) 1986; 12
Luine (10.1124/jpet.116.237412_bib114) 1998; 34
Saldanha (10.1124/jpet.116.237412_bib155) 2011; 32
Kyomen (10.1124/jpet.116.237412_bib107) 1999; 7
Ritsner (10.1124/jpet.116.237412_bib150) 2006; 26
Rissman (10.1124/jpet.116.237412_bib148) 1999; 835
Krezel (10.1124/jpet.116.237412_bib100) 2001; 98
Fisher (10.1124/jpet.116.237412_bib65) 1994; 86
Akhondzadeh (10.1124/jpet.116.237412_bib4) 2003; 27
Milad (10.1124/jpet.116.237412_bib122) 2009; 164
Kretz (10.1124/jpet.116.237412_bib99) 2004; 24
Blurton-Jones (10.1124/jpet.116.237412_bib31) 2004; 468
Kooptiwut (10.1124/jpet.116.237412_bib97) 2014; 139
Jablensky (10.1124/jpet.116.237412_bib88) 2000; 34
Hahn (10.1124/jpet.116.237412_bib77) 1999; 1
Yildiz (10.1124/jpet.116.237412_bib204) 2008; 65
Drew (10.1124/jpet.116.237412_bib55) 2000; 111
Bebo (10.1124/jpet.116.237412_bib19) 2009; 57
Waters (10.1124/jpet.116.237412_bib184) 2015; 35
Pfaff (10.1124/jpet.116.237412_bib138) 2011; 4
Sherman (10.1124/jpet.116.237412_bib165) 2014; 6
Bethea (10.1124/jpet.116.237412_bib27) 2000; 47
Yang (10.1124/jpet.116.237412_bib199) 2015; 77
Dumitriu (10.1124/jpet.116.237412_bib58) 2010; 1204
Baron-Cohen (10.1124/jpet.116.237412_bib17) 2011; 9
Vegeto (10.1124/jpet.116.237412_bib183) 2004; 91
Filardo (10.1124/jpet.116.237412_bib64) 2012; 153
Zhou (10.1124/jpet.116.237412_bib207) 2007; 203
Gruber (10.1124/jpet.116.237412_bib75) 2002; 346
Kyomen (10.1124/jpet.116.237412_bib108) 2002; 159
Yao (10.1124/jpet.116.237412_bib201) 2012; 33
Kedar (10.1124/jpet.116.237412_bib91) 1994; 343
Akama (10.1124/jpet.116.237412_bib3) 2013; 288
Hoff (10.1124/jpet.116.237412_bib83) 2001; 158
Österlund (10.1124/jpet.116.237412_bib131) 2001; 64
Shang (10.1124/jpet.116.237412_bib164) 2010; 26
Roybal (10.1124/jpet.116.237412_bib152) 2012; 49
Prange-Kiel (10.1124/jpet.116.237412_bib141) 2006; 16
Conus (10.1124/jpet.116.237412_bib47) 2007; 1
Kulkarni (10.1124/jpet.116.237412_bib102) 2014; 43
Bossé (10.1124/jpet.116.237412_bib34) 1996; 16
Strous (10.1124/jpet.116.237412_bib176) 2007; 32
Tata (10.1124/jpet.116.237412_bib178) 2005; 6
Cui (10.1124/jpet.116.237412_bib50) 2013; 19
Huang (10.1124/jpet.116.237412_bib86) 2016; 9
Solum (10.1124/jpet.116.237412_bib171) 2002; 22
Woolley (10.1124/jpet.116.237412_bib193) 1990; 10
Hao (10.1124/jpet.116.237412_bib79) 2007; 104
Adomaityte (10.1124/jpet.116.237412_bib2) 2008; 99
Amin (10.1124/jpet.116.237412_bib7) 2005; 4
Yang (10.1124/jpet.116.237412_bib200) 2010; 5
Miodovnik (10.1124/jpet.116.237412_bib124) 2012; 22
Knickmeyer (10.1124/jpet.116.237412_bib94) 2006; 49
Ritsner (10.1124/jpet.116.237412_bib149) 2006; 16
Daniel (10.1124/jpet.116.237412_bib52) 1997; 32
Gibbs (10.1124/jpet.116.237412_bib68) 2008; 149
Sherwin (10.1124/jpet.116.237412_bib167) 2008; 29
Andreescu (10.1124/jpet.116.237412_bib8) 2007; 27
Kompoliti (10.1124/jpet.116.237412_bib96) 2001; 57
Stevens (10.1124/jpet.116.237412_bib175) 2002; 159
Yague (10.1124/jpet.116.237412_bib197) 2006; 138
Haddad (10.1124/jpet.116.237412_bib76) 2004; 64
Pierman (10.1124/jpet.116.237412_bib139) 2008; 54
Kulkarni (10.1124/jpet.116.237412_bib106) 2013; 11
Bodo (10.1124/jpet.116.237412_bib32) 2006; 27
Palomba (10.1124/jpet.116.237412_bib133) 2012; 77
Meitzen (10.1124/jpet.116.237412_bib210) 2011; 42
Yague (10.1124/jpet.116.237412_bib198) 2008; 1209
Broselid (10.1124/jpet.116.237412_bib38) 2014; 289
Benedusi (10.1124/jpet.116.237412_bib24) 2012; 153
Sanches (10.1124/jpet.116.237412_bib156) 2008; 32
Dubal (10.1124/jpet.116.237412_bib56) 2001; 98
Kramár (10.1124/jpet.116.237412_bib98) 2009; 29
Schug (10.1124/jpet.116.237412_bib160) 2015; 156
Srivastava (10.1124/jpet.116.237412_bib172) 2008; 105
Kuiper (10.1124/jpet.116.237412_bib101) 1996; 93
Rhodes (10.1124/jpet.116.237412_bib145) 2006; 85
Riecher-Rössler (10.1124/jpet.116.237412_bib146) 1994; 20
Arnold (10.1124/jpet.116.237412_bib10) 2003; 26
Prossnitz (10.1124/jpet.116.237412_bib142) 2015; 67
Barrett-Connor (10.1124/jpet.116.237412_bib18) 2009; 122
Frye (10.1124/jpet.116.237412_bib66) 2005; 1036
Xu (10.1124/jpet.116.237412_bib196) 2015; 138
Bruce-Keller (10.1124/jpet.116.237412_bib40) 2000; 141
Whitehouse (10.1124/jpet.116.237412_bib190) 2010; 35
Asscheman (10.1124/jpet.116.237412_bib11) 2011; 164
Kindler (10.1124/jpet.116.237412_bib93) 2015; 40
Srivastava (10.1124/jpet.116.237412_bib173) 2010; 30
Dubal (10.1124/jpet.116.237412_bib57) 1999; 19
Perlman (10.1124/jpet.116.237412_bib137) 2005; 58
Wu (10.1124/jpet.116.237412_bib194) 2009; 139
Tordjman (10.1124/jpet.116.237412_bib179) 1997; 154
Shang (10.1124/jpet.116.237412_bib163) 2002; 295
Wei (10.1124/jpet.116.237412_bib185) 2014; 19
Rissman (10.1124/jpet.116.237412_bib147) 2002; 99
Lee (10.1124/jpet.116.237412_bib111) 2008; 26
Hu (10.1124/jpet.116.237412_bib85) 2015; 6
Gould (10.1124/jpet.116.237412_bib72) 1990; 10
Becker (10.1124/jpet.116.237412_bib21) 2000; 230
Bimonte (10.1124/jpet.116.237412_bib30) 1999; 24
Cheng (10.1124/jpet.116.237412_bib45) 2011; 286
Brann (10.1124/jpet.116.237412_bib35) 2007; 72
Pasqualini (10.1124/jpet.116.237412_bib134) 1995; 65
De Fossé (10.1124/jpet.116.237412_bib53) 2004; 56
Kulkarni (10.1124/jpet.116.237412_bib103) 2016; 73
Arad (10.1124/jpet.116.237412_bib9) 2009; 206
Kalaitzidis (10.1124/jpet.116.237412_bib89) 2005; 16
Weinberger (10.1124/jpet.116.237412_bib188) 1995; 346
Yokosuka (10.1124/jpet.116.237412_bib205) 1997; 389
Choi (10.1124/jpet.116.237412_bib46) 2004; 18
Revankar (10.1124/jpet.116.237412_bib144) 2005; 307
Dodel (10.1124/jpet.116.237412_bib54) 1999; 73
Bergemann (10.1124/jpet.116.237412_bib26) 2007; 37
Rubin (10.1124/jpet.116.237412_bib153) 2010; 124
Evans (10.1124/jpet.116.237412_bib59) 2001; 89
Brown (10.1124/jpet.116.237412_bib39) 2010; 151
Martino (10.1124/jpet.116.237412_bib118) 2013; 112
Yao (10.1124/jpet.116.237412_bib202) 2010; 1800
References_xml – volume: 17
  start-page: 2293
  year: 2008
  end-page: 2309
  ident: bib186
  article-title: Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
  publication-title: Hum Mol Genet
– volume: 204
  start-page: 105
  year: 2010
  end-page: 114
  ident: bib115
  article-title: The unfolding stories of GPR30, a new membrane-bound estrogen receptor
  publication-title: J Endocrinol
– volume: 8
  start-page: 548
  year: 2015
  end-page: 551
  ident: bib140
  article-title: Clozapine and risperidone influence on cortisol and estradiol levels in male patients with schizophrenia
  publication-title: J Med Life
– volume: 27
  start-page: 1007
  year: 2003
  end-page: 1012
  ident: bib4
  article-title: Adjunctive estrogen treatment in women with chronic schizophrenia: a double-blind, randomized, and placebo-controlled trial
  publication-title: Prog Neuropsychopharmacol Biol Psychiatry
– volume: 120
  start-page: 1190
  year: 2012
  end-page: 1194
  ident: bib136
  article-title: Prenatal bisphenol a exposure and child behavior in an inner-city cohort
  publication-title: Environ Health Perspect
– volume: 154
  start-page: 1626
  year: 1997
  end-page: 1627
  ident: bib179
  article-title: Androgenic activity in autism
  publication-title: Am J Psychiatry
– volume: 139
  start-page: 61
  year: 2009
  end-page: 72
  ident: bib194
  article-title: Estrogen masculinizes neural pathways and sex-specific behaviors
  publication-title: Cell
– volume: 230
  start-page: 134
  year: 2000
  end-page: 145
  ident: bib21
  article-title: Oestrogen effects on dopaminergic function in striatum
  publication-title: Novartis Found Symp
– volume: 6
  start-page: 26
  year: 2014
  ident: bib165
  article-title: Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI)
  publication-title: J Neurodev Disord
– volume: 159
  start-page: 713
  year: 2002
  end-page: 719
  ident: bib175
  article-title: Schizophrenia: reproductive hormones and the brain
  publication-title: Am J Psychiatry
– volume: 34
  start-page: 149
  year: 1998
  end-page: 162
  ident: bib114
  article-title: Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters
  publication-title: Horm Behav
– volume: 18
  start-page: 547
  year: 2004
  end-page: 557
  ident: bib46
  article-title: 17 β-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats
  publication-title: Fundam Clin Pharmacol
– volume: 835
  start-page: 80
  year: 1999
  end-page: 90
  ident: bib148
  article-title: Sex with knockout models: behavioral studies of estrogen receptor alpha
  publication-title: Brain Res
– volume: 36
  start-page: 272
  year: 2016
  end-page: 275
  ident: bib177
  article-title: Tamoxifen: A Protein Kinase C Inhibitor to Treat Mania: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials
  publication-title: J Clin Psychopharmacol
– volume: 98
  start-page: 1952
  year: 2001
  end-page: 1957
  ident: bib56
  article-title: Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
  publication-title: Proc Natl Acad Sci USA
– volume: 30
  start-page: 67
  year: 2008
  end-page: 76
  ident: bib120
  article-title: Schizophrenia: a concise overview of incidence, prevalence, and mortality
  publication-title: Epidemiol Rev
– volume: 60
  start-page: 288
  year: 2006
  end-page: 295
  ident: bib82
  article-title: Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field
  publication-title: Biol Psychiatry
– volume: 20
  start-page: 685
  year: 2015
  end-page: 694
  ident: bib187
  article-title: Adjunctive raloxifene treatment improves attention and memory in men and women with schizophrenia
  publication-title: Mol Psychiatry
– volume: 153
  start-page: 2777
  year: 2012
  end-page: 2788
  ident: bib24
  article-title: A lack of ovarian function increases neuroinflammation in aged mice
  publication-title: Endocrinology
– volume: 159
  start-page: 1225
  year: 2002
  end-page: 1227
  ident: bib108
  article-title: Estrogen therapy and noncognitive psychiatric signs and symptoms in elderly patients with dementia
  publication-title: Am J Psychiatry
– volume: 16
  start-page: 46
  year: 2005
  end-page: 52
  ident: bib89
  article-title: Transcription factor cross-talk: the estrogen receptor and NF-kappaB
  publication-title: Trends Endocrinol Metab
– volume: 27
  start-page: 217
  year: 2006
  end-page: 232
  ident: bib32
  article-title: New roles for estrogen receptor beta in behavior and neuroendocrinology
  publication-title: Front Neuroendocrinol
– volume: 1621
  start-page: 147
  year: 2015
  end-page: 161
  ident: bib80
  article-title: Estradiol rapidly modulates synaptic plasticity of hippocampal neurons: Involvement of kinase networks
  publication-title: Brain Res
– volume: 77
  start-page: 898
  year: 2012
  end-page: 904
  ident: bib133
  article-title: Pervasive developmental disorders in children of hyperandrogenic women with polycystic ovary syndrome: a longitudinal case-control study
  publication-title: Clin Endocrinol (Oxf)
– volume: 122
  start-page: 754
  year: 2009
  end-page: 761
  ident: bib18
  article-title: Raloxifene and risk for stroke based on the framingham stroke risk score
  publication-title: Am J Med
– volume: 65
  start-page: 255
  year: 2008
  end-page: 263
  ident: bib204
  article-title: Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen
  publication-title: Arch Gen Psychiatry
– volume: 203
  start-page: 72
  year: 2007
  end-page: 81
  ident: bib207
  article-title: Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors
  publication-title: Exp Neurol
– volume: 2015
  start-page: 615356
  year: 2015
  ident: bib71
  article-title: A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
  publication-title: Int J Endocrinol
– volume: 64
  start-page: 2291
  year: 2004
  end-page: 2314
  ident: bib76
  article-title: Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management
  publication-title: Drugs
– volume: 168
  start-page: 652
  year: 2010
  end-page: 658
  ident: bib123
  article-title: The influence of gonadal hormones on conditioned fear extinction in healthy humans
  publication-title: Neuroscience
– volume: 24
  start-page: 161
  year: 1999
  end-page: 173
  ident: bib30
  article-title: Estradiol facilitates performance as working memory load increases
  publication-title: Psychoneuroendocrinology
– volume: 22
  start-page: 2650
  year: 2002
  end-page: 2659
  ident: bib171
  article-title: Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus
  publication-title: J Neurosci
– volume: 141
  start-page: 3646
  year: 2000
  end-page: 3656
  ident: bib40
  article-title: Antiinflammatory effects of estrogen on microglial activation
  publication-title: Endocrinology
– volume: 15
  start-page: 97
  year: 1990
  end-page: 111
  ident: bib78
  article-title: Estrogen-related variations in human spatial and articulatory-motor skills
  publication-title: Psychoneuroendocrinology
– volume: 33
  start-page: 85
  year: 2012
  end-page: 104
  ident: bib161
  article-title: Estrogen neuroprotection and the critical period hypothesis
  publication-title: Front Neuroendocrinol
– volume: 24
  start-page: 223
  year: 2014
  end-page: 231
  ident: bib87
  article-title: Effects of raloxifene on cognition in postmenopausal women with schizophrenia: a double-blind, randomized, placebo-controlled trial
  publication-title: Eur Neuropsychopharmacol
– volume: 1052
  start-page: 57
  year: 2005
  end-page: 74
  ident: bib36
  article-title: Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action
  publication-title: Ann N Y Acad Sci
– volume: 32
  start-page: 217
  year: 1997
  end-page: 225
  ident: bib52
  article-title: Estrogen enhances performance of female rats during acquisition of a radial arm maze
  publication-title: Horm Behav
– volume: 346
  start-page: 340
  year: 2002
  end-page: 352
  ident: bib75
  article-title: Production and actions of estrogens
  publication-title: N Engl J Med
– volume: 29
  start-page: 12982
  year: 2009
  end-page: 12993
  ident: bib98
  article-title: Cytoskeletal changes underlie estrogen’s acute effects on synaptic transmission and plasticity
  publication-title: J Neurosci
– volume: 34
  start-page: 221
  year: 2000
  end-page: 236
  ident: bib88
  article-title: Psychotic disorders in urban areas: an overview of the Study on Low Prevalence Disorders
  publication-title: Aust N Z J Psychiatry
– volume: 139
  start-page: 25
  year: 2014
  end-page: 32
  ident: bib97
  article-title: Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic β-cell death
  publication-title: J Steroid Biochem Mol Biol
– volume: 346
  start-page: 552
  year: 1995
  end-page: 557
  ident: bib188
  article-title: From neuropathology to neurodevelopment
  publication-title: Lancet
– volume: 19
  start-page: 6385
  year: 1999
  end-page: 6393
  ident: bib57
  article-title: Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors
  publication-title: J Neurosci
– volume: 77
  start-page: 618
  year: 2015
  end-page: 636
  ident: bib199
  article-title: Increased coupling of caveolin-1 and estrogen receptor α contributes to the fragile X syndrome
  publication-title: Ann Neurol
– volume: 45
  start-page: S116
  year: 2001
  end-page: S124
  ident: bib127
  article-title: Estrogen production and action
  publication-title: J Am Acad Dermatol
– volume: 106
  start-page: 1229
  year: 2000
  end-page: 1237
  ident: bib42
  article-title: Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α
  publication-title: J Clin Invest
– volume: 28
  start-page: 8660
  year: 2008
  end-page: 8667
  ident: bib62
  article-title: Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors
  publication-title: J Neurosci
– volume: 286
  start-page: 22441
  year: 2011
  end-page: 22455
  ident: bib45
  article-title: Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway
  publication-title: J Biol Chem
– volume: 35
  start-page: 2384
  year: 2015
  end-page: 2397
  ident: bib184
  article-title: G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus
  publication-title: J Neurosci
– volume: 25
  start-page: 560
  year: 2013
  end-page: 569
  ident: bib157
  article-title: Oestradiol modulation of serotonin reuptake transporter and serotonin metabolism in the brain of monkeys
  publication-title: J Neuroendocrinol
– volume: 206
  start-page: 731
  year: 2009
  end-page: 740
  ident: bib9
  article-title: Disruption of latent inhibition induced by ovariectomy can be reversed by estradiol and clozapine as well as by co-administration of haloperidol with estradiol but not by haloperidol alone
  publication-title: Psychopharmacology (Berl)
– volume: 24
  start-page: 5913
  year: 2004
  end-page: 5921
  ident: bib99
  article-title: Hippocampal synapses depend on hippocampal estrogen synthesis
  publication-title: J Neurosci
– volume: 99
  start-page: 338
  year: 2008
  end-page: 342
  ident: bib2
  article-title: Effect of raloxifene therapy on venous thromboembolism in postmenopausal women. A meta-analysis
  publication-title: Thromb Haemost
– volume: 91
  start-page: 59
  year: 2004
  end-page: 66
  ident: bib183
  article-title: Regulation of the lipopolysaccharide signal transduction pathway by 17beta-estradiol in macrophage cells
  publication-title: J Steroid Biochem Mol Biol
– volume: 20
  start-page: 695
  year: 2015
  end-page: 702
  ident: bib104
  article-title: Estradiol for treatment-resistant schizophrenia: a large-scale randomized-controlled trial in women of child-bearing age
  publication-title: Mol Psychiatry
– volume: 9
  start-page: e1001081
  year: 2011
  ident: bib17
  article-title: Why are autism spectrum conditions more prevalent in males?
  publication-title: PLoS Biol
– volume: 232
  start-page: 2981
  year: 2015
  end-page: 2994
  ident: bib109
  article-title: Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice
  publication-title: Psychopharmacology (Berl)
– volume: 124
  start-page: 13
  year: 2010
  end-page: 21
  ident: bib153
  article-title: Peripheral oxytocin is associated with reduced symptom severity in schizophrenia
  publication-title: Schizophr Res
– volume: 191
  start-page: 139
  year: 2011
  end-page: 147
  ident: bib15
  article-title: Estradiol synthesis within the human brain
  publication-title: Neuroscience
– volume: 1
  start-page: 133
  year: 2010
  end-page: 143
  ident: bib128
  article-title: Functional interactions between steroid hormones and neurotrophin BDNF
  publication-title: World J Biol Chem
– volume: 21
  start-page: 1809
  year: 2001
  end-page: 1818
  ident: bib182
  article-title: Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia
  publication-title: J Neurosci
– volume: 98
  start-page: 12278
  year: 2001
  end-page: 12282
  ident: bib100
  article-title: Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice
  publication-title: Proc Natl Acad Sci USA
– volume: 1209
  start-page: 115
  year: 2008
  end-page: 127
  ident: bib198
  article-title: Aromatase distribution in the monkey temporal neocortex and hippocampus
  publication-title: Brain Res
– volume: 32
  start-page: 96
  year: 2007
  end-page: 105
  ident: bib176
  article-title: Analysis of clinical symptomatology, extrapyramidal symptoms and neurocognitive dysfunction following dehydroepiandrosterone (DHEA) administration in olanzapine treated schizophrenia patients: a randomized, double-blind placebo controlled trial
  publication-title: Psychoneuroendocrinology
– volume: 175
  start-page: 130
  year: 2006
  end-page: 135
  ident: bib22
  article-title: Testosterone loss and estradiol administration modify memory in men
  publication-title: J Urol
– volume: 29
  start-page: 88
  year: 2008
  end-page: 113
  ident: bib167
  article-title: Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review
  publication-title: Front Neuroendocrinol
– volume: 60
  start-page: 1504
  year: 2008
  end-page: 1511
  ident: bib37
  article-title: Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer’s disease
  publication-title: Adv Drug Deliv Rev
– volume: 7
  start-page: 136
  year: 2013
  ident: bib5
  article-title: Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment
  publication-title: Front Behav Neurosci
– volume: 153
  start-page: 2953
  year: 2012
  end-page: 2962
  ident: bib64
  article-title: Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology
  publication-title: Endocrinology
– volume: 42
  start-page: 236
  year: 2011
  end-page: 241
  ident: bib210
  article-title: Estrogen receptors stimulate brain region specific metabotropic glutamate receptors to rapidly initiate signal transduction pathways
  publication-title: J Chem Neuroanat
– volume: 100
  start-page: 9614
  year: 2003
  end-page: 9619
  ident: bib181
  article-title: Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol
  publication-title: Proc Natl Acad Sci USA
– volume: 31
  start-page: 1508
  year: 2006
  end-page: 1518
  ident: bib69
  article-title: Raloxifene treatment enhances brain activation during recognition of familiar items: a pharmacological fMRI study in healthy elderly males
  publication-title: Neuropsychopharmacology
– volume: 57
  start-page: 1519
  year: 2001
  ident: bib96
  article-title: Estrogen, progesterone, and tic severity in women with Gilles de la Tourette syndrome
  publication-title: Neurology
– volume: 1800
  start-page: 1121
  year: 2010
  end-page: 1126
  ident: bib202
  article-title: Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence
  publication-title: Biochim Biophys Acta
– reference: S0006-3223(16)32427-1 10.1016/j.biopsych.2016.05.022.
– volume: 4
  start-page: 163
  year: 2011
  end-page: 176
  ident: bib138
  article-title: Male predominance in autism: neuroendocrine influences on arousal and social anxiety
  publication-title: Autism Res
– volume: 39
  start-page: 130
  year: 2013
  end-page: 140
  ident: bib192
  article-title: Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia
  publication-title: Schizophr Bull
– volume: 146
  start-page: 38
  year: 2015
  end-page: 47
  ident: bib92
  article-title: Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia
  publication-title: J Steroid Biochem Mol Biol
– volume: 138
  start-page: 13
  year: 2015
  end-page: 20
  ident: bib196
  article-title: Prenatal hyperandrogenic environment induced autistic-like behavior in rat offspring
  publication-title: Physiol Behav
– volume: 26
  start-page: 549
  year: 2012
  end-page: 557
  ident: bib105
  article-title: Role of estrogen treatment in the management of schizophrenia
  publication-title: CNS Drugs
– volume: 57
  start-page: 777
  year: 2009
  end-page: 790
  ident: bib19
  article-title: Treatment with selective estrogen receptor modulators regulates myelin specific T-cells and suppresses experimental autoimmune encephalomyelitis
  publication-title: Glia
– volume: 231
  start-page: 1150
  year: 1986
  end-page: 1154
  ident: bib74
  article-title: Sequence and expression of human estrogen receptor complementary DNA
  publication-title: Science
– volume: 65
  start-page: 1651
  year: 1995
  end-page: 1657
  ident: bib134
  article-title: Acute stimulatory effect of estradiol on striatal dopamine synthesis
  publication-title: J Neurochem
– volume: 389
  start-page: 81
  year: 1997
  end-page: 93
  ident: bib205
  article-title: Postnatal development and sex difference in neurons containing estrogen receptor-alpha immunoreactivity in the preoptic brain, the diencephalon, and the amygdala in the rat
  publication-title: J Comp Neurol
– volume: 10
  start-page: 4035
  year: 1990
  end-page: 4039
  ident: bib193
  article-title: Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons
  publication-title: J Neurosci
– volume: 23
  start-page: 69
  year: 2000
  end-page: 78
  ident: bib51
  article-title: Modulation by estrogen-receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain
  publication-title: Neuropsychopharmacology
– volume: 36
  start-page: 1483
  year: 2016
  end-page: 1489
  ident: bib180
  article-title: Estradiol-mediated spine changes in the dorsal hippocampus and medial prefrontal cortex of ovariectomized female mice depend on ERK and mTOR activation in the dorsal hippocampus
  publication-title: J Neurosci
– volume: 104
  start-page: 323
  year: 2001
  end-page: 331
  ident: bib116
  article-title: Oestrogen withdrawal associated psychoses
  publication-title: Acta Psychiatr Scand
– volume: 73
  start-page: 1453
  year: 1999
  end-page: 1460
  ident: bib54
  article-title: Sodium salicylate and 17beta-estradiol attenuate nuclear transcription factor NF-kappaB translocation in cultured rat astroglial cultures following exposure to amyloid A beta(1-40) and lipopolysaccharides
  publication-title: J Neurochem
– volume: 112
  start-page: 239
  year: 2013
  end-page: 279
  ident: bib118
  article-title: Neuroendocrine aspects of Tourette syndrome
  publication-title: Int Rev Neurobiol
– volume: 343
  start-page: 1318
  year: 1994
  end-page: 1321
  ident: bib91
  article-title: Effects of tamoxifen on uterus and ovaries of postmenopausal women in a randomised breast cancer prevention trial
  publication-title: Lancet
– volume: 320
  start-page: 134
  year: 1986
  end-page: 139
  ident: bib73
  article-title: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
  publication-title: Nature
– volume: 6
  start-page: 490
  year: 2005
  end-page: 496
  ident: bib178
  article-title: One hundred years of hormones
  publication-title: EMBO Rep
– volume: 288
  start-page: 6438
  year: 2013
  end-page: 6450
  ident: bib3
  article-title: Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines
  publication-title: J Biol Chem
– volume: 32
  start-page: 532
  year: 2011
  end-page: 549
  ident: bib155
  article-title: Synaptocrine signaling: steroid synthesis and action at the synapse
  publication-title: Endocr Rev
– volume: 138
  start-page: 389
  year: 2006
  end-page: 401
  ident: bib197
  article-title: Aromatase expression in the human temporal cortex
  publication-title: Neuroscience
– volume: 77
  start-page: 60
  year: 2016
  end-page: 67
  ident: bib203
  article-title: Estrogen modulation of calretinin and BDNF expression in midbrain dopaminergic neurons of ovariectomised mice
  publication-title: J Chem Neuroanat
– volume: 19
  start-page: 588
  year: 2014
  end-page: 598
  ident: bib185
  article-title: Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition
  publication-title: Mol Psychiatry
– volume: 81
  start-page: 294
  year: 2005
  end-page: 310
  ident: bib206
  article-title: Effects of estrogen treatment on expression of brain-derived neurotrophic factor and cAMP response element-binding protein expression and phosphorylation in rat amygdaloid and hippocampal structures
  publication-title: Neuroendocrinology
– volume: 114
  start-page: 17
  year: 2009
  end-page: 24
  ident: bib48
  article-title: Gender differences in premorbid, entry, treatment, and outcome characteristics in a treated epidemiological sample of 661 patients with first episode psychosis
  publication-title: Schizophr Res
– volume: 111
  start-page: 77
  year: 2000
  end-page: 85
  ident: bib55
  article-title: Female sex steroids: effects upon microglial cell activation
  publication-title: J Neuroimmunol
– volume: 34
  start-page: 4130
  year: 2015
  end-page: 4141
  ident: bib143
  article-title: ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway
  publication-title: Oncogene
– volume: 16
  start-page: 137
  year: 2006
  end-page: 146
  ident: bib149
  article-title: Alterations in DHEA metabolism in schizophrenia: two-month case-control study
  publication-title: Eur Neuropsychopharmacol
– volume: 49
  start-page: 282
  year: 2006
  end-page: 292
  ident: bib94
  article-title: Fetal testosterone and empathy
  publication-title: Horm Behav
– volume: 4
  start-page: 43
  year: 2005
  end-page: 58
  ident: bib7
  article-title: Effect of estrogen-serotonin interactions on mood and cognition
  publication-title: Behav Cogn Neurosci Rev
– volume: 289
  start-page: 22117
  year: 2014
  end-page: 22127
  ident: bib38
  article-title: G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production
  publication-title: J Biol Chem
– volume: 2
  start-page: 157
  year: 2009
  end-page: 177
  ident: bib43
  article-title: Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome
  publication-title: Autism Res
– reference: Hoftman GD, Datta D, Lewis DA (2016) Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia.
– volume: 29
  start-page: 241
  year: 2006
  end-page: 249
  ident: bib16
  article-title: Is brain estradiol a hormone or a neurotransmitter?
  publication-title: Trends Neurosci
– volume: 151
  start-page: 4916
  year: 2010
  end-page: 4925
  ident: bib39
  article-title: Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta
  publication-title: Endocrinology
– volume: 57
  start-page: 309
  year: 2008
  end-page: 320
  ident: bib189
  article-title: Estrogen receptor beta in the brain: from form to function
  publication-title: Brain Res Brain Res Rev
– volume: 49
  start-page: 28
  year: 2012
  end-page: 43
  ident: bib152
  article-title: Biological evidence for a neurodevelopmental model of pediatric bipolar disorder
  publication-title: Isr J Psychiatry Relat Sci
– volume: 56
  start-page: 757
  year: 2004
  end-page: 766
  ident: bib53
  article-title: Language-association cortex asymmetry in autism and specific language impairment
  publication-title: Ann Neurol
– volume: 99
  start-page: 3996
  year: 2002
  end-page: 4001
  ident: bib147
  article-title: Disruption of estrogen receptor beta gene impairs spatial learning in female mice
  publication-title: Proc Natl Acad Sci USA
– volume: 16
  start-page: 199
  year: 1996
  end-page: 212
  ident: bib34
  article-title: The modulation of brain dopamine and GABAA receptors by estradiol: a clue for CNS changes occurring at menopause
  publication-title: Cell Mol Neurobiol
– volume: 32
  start-page: 1808
  year: 2011
  end-page: 1817
  ident: bib166
  article-title: A randomized controlled trial of estrogen treatment in men with mild cognitive impairment
  publication-title: Neurobiol Aging
– volume: 295
  start-page: 2465
  year: 2002
  end-page: 2468
  ident: bib163
  article-title: Molecular determinants for the tissue specificity of SERMs
  publication-title: Science
– volume: 27
  start-page: 431
  year: 2002
  end-page: 445
  ident: bib28
  article-title: Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques
  publication-title: Psychoneuroendocrinology
– volume: 1204
  start-page: 104
  year: 2010
  end-page: 112
  ident: bib58
  article-title: Estrogen and the aging brain: an elixir for the weary cortical network
  publication-title: Ann N Y Acad Sci
– volume: 25
  start-page: 409
  year: 2002
  end-page: 432
  ident: bib112
  article-title: Schizophrenia as a disorder of neurodevelopment
  publication-title: Annu Rev Neurosci
– volume: 20
  start-page: 203
  year: 1994
  end-page: 214
  ident: bib146
  article-title: Can estradiol modulate schizophrenic symptomatology?
  publication-title: Schizophr Bull
– volume: 26
  start-page: 48
  year: 2008
  end-page: 52
  ident: bib111
  article-title: Raloxifene, a selective estrogen receptor modulator, inhibits lipopolysaccharide-induced nitric oxide production by inhibiting the phosphatidylinositol 3-kinase/Akt/nuclear factor-kappa B pathway in RAW264.7 macrophage cells
  publication-title: Mol Cells
– volume: 30
  start-page: 13454
  year: 2010
  end-page: 13460
  ident: bib173
  article-title: Estrogen receptor ß activity modulates synaptic signaling and structure
  publication-title: J Neurosci
– volume: 1036
  start-page: 101
  year: 2005
  end-page: 108
  ident: bib66
  article-title: Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks
  publication-title: Brain Res
– volume: 64
  start-page: 251
  year: 2001
  end-page: 267
  ident: bib131
  article-title: Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders
  publication-title: Prog Neurobiol
– volume: 164
  start-page: 635
  year: 2011
  end-page: 642
  ident: bib11
  article-title: A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones
  publication-title: Eur J Endocrinol
– volume: 40
  start-page: 2388
  year: 2015
  end-page: 2397
  ident: bib93
  article-title: Selective Estrogen Receptor Modulation Increases Hippocampal Activity during Probabilistic Association Learning in Schizophrenia
  publication-title: Neuropsychopharmacology
– volume: 1007
  start-page: 54
  year: 2003
  end-page: 63
  ident: bib132
  article-title: Estrogen receptor gene expression in relation to neuropsychiatric disorders
  publication-title: Ann N Y Acad Sci
– volume: 72
  start-page: 381
  year: 2007
  end-page: 405
  ident: bib35
  article-title: Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications
  publication-title: Steroids
– volume: 136
  start-page: 833
  year: 2005
  end-page: 842
  ident: bib154
  article-title: Neurosteroid synthesis in the hippocampus: role in synaptic plasticity
  publication-title: Neuroscience
– volume: 30
  start-page: 4390
  year: 2010
  end-page: 4400
  ident: bib61
  article-title: Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippocampal extracellular signal-regulated kinase and phosphatidylinositol 3-kinase activation
  publication-title: J Neurosci
– volume: 42
  start-page: 74
  year: 2008
  end-page: 82
  ident: bib125
  article-title: Do women express and experience psychosis differently from men? Epidemiological evidence from the Australian National Study of Low Prevalence (Psychotic) Disorders
  publication-title: Aust N Z J Psychiatry
– volume: 76
  start-page: 1243
  year: 1986
  end-page: 1246
  ident: bib129
  article-title: Triphenylethylenes: a new class of protein kinase C inhibitors
  publication-title: J Natl Cancer Inst
– volume: 181
  start-page: 209
  year: 2010
  end-page: 232
  ident: bib33
  article-title: The multiple roles of estrogens and the enzyme aromatase
  publication-title: Prog Brain Res
– volume: 20
  start-page: 252
  year: 1997
  end-page: 258
  ident: bib130
  article-title: NF-kappa B: a crucial transcription factor for glial and neuronal cell function
  publication-title: Trends Neurosci
– volume: 1
  start-page: 191
  year: 2007
  end-page: 200
  ident: bib47
  article-title: The first-episode psychosis outcome study: Premorbid and baseline characteristics of an epidemiological cohort of 661 first-episode psychosis patients
  publication-title: Early Interv Psychiatry
– volume: 14
  start-page: 1979
  year: 2003
  end-page: 1982
  ident: bib117
  article-title: Impaired spatial reference memory in aromatase-deficient (ArKO) mice
  publication-title: Neuroreport
– volume: 52
  start-page: 352
  year: 2007
  end-page: 359
  ident: bib67
  article-title: Estradiol enhances DMP acquisition via a mechanism not mediated by turning strategy but which requires intact basal forebrain cholinergic projections
  publication-title: Horm Behav
– volume: 105
  start-page: 14650
  year: 2008
  end-page: 14655
  ident: bib172
  article-title: Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity
  publication-title: Proc Natl Acad Sci USA
– volume: 47
  start-page: 437
  year: 2002
  end-page: 442
  ident: bib208
  article-title: The role of estrogen in schizophrenia: implications for schizophrenia practice guidelines for women
  publication-title: Can J Psychiatry
– volume: 26
  start-page: 595
  year: 2003
  end-page: 620
  ident: bib10
  article-title: Gender differences in bipolar disorder
  publication-title: Psychiatr Clin North Am
– volume: 73
  start-page: 947
  year: 2016
  end-page: 954
  ident: bib103
  article-title: Effect of adjunctive raloxifene therapy on severity of refractory schizophrenia in women: a randomized clinical trial
  publication-title: JAMA Psychiatry
– volume: 156
  start-page: 1941
  year: 2015
  end-page: 1951
  ident: bib160
  article-title: Elucidating the links between endocrine disruptors and neurodevelopment
  publication-title: Endocrinology
– volume: 5
  start-page: 620
  year: 2009
  end-page: 627
  ident: bib168
  article-title: Estrogen therapy: is time of initiation critical for neuroprotection?
  publication-title: Nat Rev Endocrinol
– volume: 67
  start-page: 505
  year: 2015
  end-page: 540
  ident: bib142
  article-title: International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators
  publication-title: Pharmacol Rev
– volume: 85
  start-page: 183
  year: 2006
  end-page: 191
  ident: bib145
  article-title: ERbeta-selective SERMs produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks
  publication-title: Neurobiol Learn Mem
– volume: 11
  start-page: 334
  year: 2008
  end-page: 343
  ident: bib113
  article-title: Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory
  publication-title: Nat Neurosci
– year: 2013
  ident: bib6
  publication-title: Diagnostic and Statistical Manual of Mental Disorders
– volume: 26
  start-page: 495
  year: 2006
  end-page: 499
  ident: bib150
  article-title: Improvement of sustained attention and visual and movement skills, but not clinical symptoms, after dehydroepiandrosterone augmentation in schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial
  publication-title: J Clin Psychopharmacol
– volume: 7
  start-page: 339
  year: 1999
  end-page: 348
  ident: bib107
  article-title: Estrogen therapy and aggressive behavior in elderly patients with moderate-to-severe dementia: results from a short-term, randomized, double-blind trial
  publication-title: Am J Geriatr Psychiatry
– volume: 142
  start-page: 671
  year: 2015
  end-page: 679
  ident: bib41
  article-title: Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort
  publication-title: Environ Res
– volume: 26
  start-page: 133
  year: 2010
  end-page: 139
  ident: bib164
  article-title: Effects of synaptic plasticity regulated by 17beta-estradiol on learning and memory in rats with Alzheimer’s disease
  publication-title: Neurosci Bull
– volume: 36
  start-page: 1422
  year: 2011
  end-page: 1426
  ident: bib121
  article-title: Associations of sex steroid hormones with cerebral activations during mental rotation in men and women with schizophrenia
  publication-title: Psychoneuroendocrinology
– volume: 37
  start-page: 1427
  year: 2007
  end-page: 1436
  ident: bib26
  article-title: Estrogen, menstrual cycle phases, and psychopathology in women suffering from schizophrenia
  publication-title: Psychol Med
– volume: 27
  start-page: 10832
  year: 2007
  end-page: 10839
  ident: bib8
  article-title: Estradiol improves cerebellar memory formation by activating estrogen receptor beta
  publication-title: J Neurosci
– volume: 150
  start-page: 662
  year: 1987
  end-page: 673
  ident: bib90
  article-title: Epidemiology of puerperal psychoses
  publication-title: Br J Psychiatry
– volume: 16
  start-page: 7021
  year: 1996
  end-page: 7029
  ident: bib135
  article-title: Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques
  publication-title: J Neurosci
– volume: 468
  start-page: 347
  year: 2004
  end-page: 360
  ident: bib31
  article-title: Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression
  publication-title: J Comp Neurol
– volume: 6
  start-page: 7
  year: 2015
  ident: bib85
  article-title: Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism
  publication-title: Mol Autism
– volume: 16
  start-page: 464
  year: 2006
  end-page: 471
  ident: bib141
  article-title: Inhibition of hippocampal estrogen synthesis causes region-specific downregulation of synaptic protein expression in hippocampal neurons
  publication-title: Hippocampus
– volume: 86
  start-page: 527
  year: 1994
  end-page: 537
  ident: bib65
  article-title: Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14
  publication-title: J Natl Cancer Inst
– volume: 104
  start-page: 11465
  year: 2007
  end-page: 11470
  ident: bib79
  article-title: Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex
  publication-title: Proc Natl Acad Sci USA
– volume: 3
  start-page: 433
  year: 2002
  end-page: 442
  ident: bib23
  article-title: Oestrogen as a neuroprotective hormone
  publication-title: Nat Rev Neurosci
– volume: 281
  start-page: 2189
  year: 1999
  end-page: 2197
  ident: bib209
  article-title: The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
  publication-title: JAMA
– volume: 35
  start-page: 1259
  year: 2010
  end-page: 1264
  ident: bib190
  article-title: Fetal androgen exposure and pragmatic language ability of girls in middle childhood: implications for the extreme male-brain theory of autism
  publication-title: Psychoneuroendocrinology
– volume: 158
  start-page: 1134
  year: 2001
  end-page: 1139
  ident: bib83
  article-title: Association of estrogen levels with neuropsychological performance in women with schizophrenia
  publication-title: Am J Psychiatry
– volume: 89
  start-page: 823
  year: 2001
  end-page: 830
  ident: bib59
  article-title: Reciprocal antagonism between estrogen receptor and NF-kappaB activity in vivo
  publication-title: Circ Res
– volume: 164
  start-page: 887
  year: 2009
  end-page: 895
  ident: bib122
  article-title: Estrous cycle phase and gonadal hormones influence conditioned fear extinction
  publication-title: Neuroscience
– volume: 88
  start-page: 91
  year: 2008
  end-page: 124
  ident: bib119
  article-title: Estradiol and the developing brain
  publication-title: Physiol Rev
– volume: 22
  start-page: 115
  year: 2012
  end-page: 122
  ident: bib124
  article-title: Polymorphisms in the maternal sex steroid pathway are associated with behavior problems in male offspring
  publication-title: Psychiatr Genet
– volume: 34
  start-page: 1172
  year: 2008
  end-page: 1181
  ident: bib25
  article-title: Estrogen and comprehension of metaphoric speech in women suffering from schizophrenia: results of a double-blind, placebo-controlled trial
  publication-title: Schizophr Bull
– volume: 53
  start-page: 169
  year: 2006
  end-page: 175
  ident: bib95
  article-title: Estrogen, cognitive function and negative symptoms in female schizophrenia
  publication-title: Neuropsychobiology
– volume: 5
  start-page: 46
  year: 2014
  ident: bib49
  article-title: Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects
  publication-title: Mol Autism
– volume: 1
  start-page: 81
  year: 1999
  end-page: 86
  ident: bib77
  article-title: Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder
  publication-title: Bipolar Disord
– volume: 12
  start-page: 36
  year: 1986
  end-page: 41
  ident: bib44
  article-title: Psychosis and pregnancy
  publication-title: Compr Ther
– volume: 9
  start-page: 3415
  year: 2016
  end-page: 3422
  ident: bib86
  article-title: GPR30 decreases with vascular aging and promotes vascular smooth muscle cells maintaining differentiated phenotype and suppressing migration via activation of ERK1/2
  publication-title: Onco Targets Ther
– volume: 11
  start-page: 129
  year: 2013
  end-page: 136
  ident: bib106
  article-title: The role of estrogen in the treatment of men with schizophrenia
  publication-title: Int J Endocrinol Metab
– volume: 43
  start-page: 52
  year: 2014
  end-page: 61
  ident: bib102
  article-title: A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania
  publication-title: Psychoneuroendocrinology
– volume: 180
  start-page: 155
  year: 1994
  end-page: 158
  ident: bib195
  article-title: Quantitative microdialysis determination of extracellular striatal dopamine concentration in male and female rats: effects of estrous cycle and gonadectomy
  publication-title: Neurosci Lett
– volume: 5
  start-page: e9851
  year: 2010
  ident: bib200
  article-title: Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus
  publication-title: PLoS One
– volume: 10
  start-page: 1286
  year: 1990
  end-page: 1291
  ident: bib72
  article-title: Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
  publication-title: J Neurosci
– volume: 307
  start-page: 1625
  year: 2005
  end-page: 1630
  ident: bib144
  article-title: A transmembrane intracellular estrogen receptor mediates rapid cell signaling
  publication-title: Science
– volume: 32
  start-page: 1617
  year: 2008
  end-page: 1627
  ident: bib156
  article-title: Neurodevelopmental basis of bipolar disorder: a critical appraisal
  publication-title: Prog Neuropsychopharmacol Biol Psychiatry
– volume: 16
  start-page: 362
  year: 2005
  end-page: 367
  ident: bib63
  article-title: GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
  publication-title: Trends Endocrinol Metab
– volume: 118
  start-page: 169
  year: 1990
  end-page: 171
  ident: bib20
  article-title: Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis
  publication-title: Neurosci Lett
– volume: 47
  start-page: 562
  year: 2000
  end-page: 576
  ident: bib27
  article-title: Steroid regulation of tryptophan hydroxylase protein in the dorsal raphe of macaques
  publication-title: Biol Psychiatry
– volume: 97
  start-page: 3602
  year: 2000
  end-page: 3607
  ident: bib29
  article-title: The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus
  publication-title: Proc Natl Acad Sci USA
– volume: 76
  start-page: 214
  year: 2002
  end-page: 222
  ident: bib110
  article-title: Estrogenic properties of raloxifene, but not tamoxifen, on D2 and D3 dopamine receptors in the rat forebrain
  publication-title: Neuroendocrinology
– volume: 58
  start-page: 812
  year: 2005
  end-page: 824
  ident: bib137
  article-title: Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illness
  publication-title: Biol Psychiatry
– volume: 54
  start-page: 98
  year: 2008
  end-page: 106
  ident: bib139
  article-title: Activational effects of estradiol and dihydrotestosterone on social recognition and the arginine-vasopressin immunoreactive system in male mice lacking a functional aromatase gene
  publication-title: Horm Behav
– volume: 93
  start-page: 5925
  year: 1996
  end-page: 5930
  ident: bib101
  article-title: Cloning of a novel receptor expressed in rat prostate and ovary
  publication-title: Proc Natl Acad Sci USA
– volume: 644
  start-page: 305
  year: 1994
  end-page: 312
  ident: bib170
  article-title: Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats
  publication-title: Brain Res
– volume: 100
  start-page: 1
  year: 2009
  end-page: 22
  ident: bib13
  article-title: Fetal testosterone and autistic traits
  publication-title: Br J Psychol
– volume: 3
  start-page: 17
  year: 2012
  ident: bib12
  article-title: Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age
  publication-title: Mol Autism
– volume: 19
  start-page: 197
  year: 2013
  end-page: 209
  ident: bib50
  article-title: Estrogen synthesis and signaling pathways during aging: from periphery to brain
  publication-title: Trends Mol Med
– volume: 10
  start-page: 16
  year: 2016
  end-page: 25
  ident: bib60
  article-title: Effect of tamoxifen and lithium on treatment of acute mania symptoms in children and adolescents
  publication-title: Iran J Child Neurol
– volume: 52
  start-page: 185
  year: 1997
  end-page: 213
  ident: bib169
  article-title: Aromatase expression in health and disease
  publication-title: Recent Prog Horm Res
– volume: 149
  start-page: 3176
  year: 2008
  end-page: 3183
  ident: bib68
  article-title: Sex-specific effects of gonadectomy and hormone treatment on acquisition of a 12-arm radial maze task by Sprague Dawley rats
  publication-title: Endocrinology
– volume: 33
  start-page: 1507
  year: 2012
  end-page: 1521
  ident: bib201
  article-title: Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid
  publication-title: Neurobiol Aging
– volume: 15
  start-page: 97
  year: 1990
  ident: 10.1124/jpet.116.237412_bib78
  article-title: Estrogen-related variations in human spatial and articulatory-motor skills
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/0306-4530(90)90018-5
– volume: 36
  start-page: 1422
  year: 2011
  ident: 10.1124/jpet.116.237412_bib121
  article-title: Associations of sex steroid hormones with cerebral activations during mental rotation in men and women with schizophrenia
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2011.03.016
– ident: 10.1124/jpet.116.237412_bib84
– volume: 175
  start-page: 130
  year: 2006
  ident: 10.1124/jpet.116.237412_bib22
  article-title: Testosterone loss and estradiol administration modify memory in men
  publication-title: J Urol
  doi: 10.1016/S0022-5347(05)00049-2
– volume: 30
  start-page: 4390
  year: 2010
  ident: 10.1124/jpet.116.237412_bib61
  article-title: Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippocampal extracellular signal-regulated kinase and phosphatidylinositol 3-kinase activation
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4333-09.2010
– volume: 65
  start-page: 1651
  year: 1995
  ident: 10.1124/jpet.116.237412_bib134
  article-title: Acute stimulatory effect of estradiol on striatal dopamine synthesis
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.1995.65041651.x
– volume: 57
  start-page: 309
  year: 2008
  ident: 10.1124/jpet.116.237412_bib189
  article-title: Estrogen receptor beta in the brain: from form to function
  publication-title: Brain Res Brain Res Rev
  doi: 10.1016/j.brainresrev.2007.05.013
– volume: 231
  start-page: 1150
  year: 1986
  ident: 10.1124/jpet.116.237412_bib74
  article-title: Sequence and expression of human estrogen receptor complementary DNA
  publication-title: Science
  doi: 10.1126/science.3753802
– volume: 43
  start-page: 52
  year: 2014
  ident: 10.1124/jpet.116.237412_bib102
  article-title: A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2014.02.004
– volume: 7
  start-page: 339
  year: 1999
  ident: 10.1124/jpet.116.237412_bib107
  article-title: Estrogen therapy and aggressive behavior in elderly patients with moderate-to-severe dementia: results from a short-term, randomized, double-blind trial
  publication-title: Am J Geriatr Psychiatry
– volume: 154
  start-page: 1626
  year: 1997
  ident: 10.1124/jpet.116.237412_bib179
  article-title: Androgenic activity in autism
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.154.11.1626-a
– volume: 32
  start-page: 96
  year: 2007
  ident: 10.1124/jpet.116.237412_bib176
  article-title: Analysis of clinical symptomatology, extrapyramidal symptoms and neurocognitive dysfunction following dehydroepiandrosterone (DHEA) administration in olanzapine treated schizophrenia patients: a randomized, double-blind placebo controlled trial
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2006.11.002
– volume: 104
  start-page: 11465
  year: 2007
  ident: 10.1124/jpet.116.237412_bib79
  article-title: Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0704757104
– volume: 16
  start-page: 7021
  year: 1996
  ident: 10.1124/jpet.116.237412_bib135
  article-title: Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.16-21-07021.1996
– volume: 24
  start-page: 5913
  year: 2004
  ident: 10.1124/jpet.116.237412_bib99
  article-title: Hippocampal synapses depend on hippocampal estrogen synthesis
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5186-03.2004
– volume: 146
  start-page: 38
  year: 2015
  ident: 10.1124/jpet.116.237412_bib92
  article-title: Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2014.05.001
– volume: 289
  start-page: 22117
  year: 2014
  ident: 10.1124/jpet.116.237412_bib38
  article-title: G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M114.566893
– volume: 49
  start-page: 282
  year: 2006
  ident: 10.1124/jpet.116.237412_bib94
  article-title: Fetal testosterone and empathy
  publication-title: Horm Behav
  doi: 10.1016/j.yhbeh.2005.08.010
– volume: 10
  start-page: 4035
  year: 1990
  ident: 10.1124/jpet.116.237412_bib193
  article-title: Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.10-12-04035.1990
– volume: 26
  start-page: 549
  year: 2012
  ident: 10.1124/jpet.116.237412_bib105
  article-title: Role of estrogen treatment in the management of schizophrenia
  publication-title: CNS Drugs
  doi: 10.2165/11630660-000000000-00000
– volume: 34
  start-page: 4130
  year: 2015
  ident: 10.1124/jpet.116.237412_bib143
  article-title: ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway
  publication-title: Oncogene
  doi: 10.1038/onc.2014.343
– volume: 34
  start-page: 221
  year: 2000
  ident: 10.1124/jpet.116.237412_bib88
  article-title: Psychotic disorders in urban areas: an overview of the Study on Low Prevalence Disorders
  publication-title: Aust N Z J Psychiatry
  doi: 10.1080/j.1440-1614.2000.00728.x
– volume: 32
  start-page: 532
  year: 2011
  ident: 10.1124/jpet.116.237412_bib155
  article-title: Synaptocrine signaling: steroid synthesis and action at the synapse
  publication-title: Endocr Rev
  doi: 10.1210/er.2011-0004
– volume: 77
  start-page: 898
  year: 2012
  ident: 10.1124/jpet.116.237412_bib133
  article-title: Pervasive developmental disorders in children of hyperandrogenic women with polycystic ovary syndrome: a longitudinal case-control study
  publication-title: Clin Endocrinol (Oxf)
  doi: 10.1111/j.1365-2265.2012.04443.x
– volume: 85
  start-page: 183
  year: 2006
  ident: 10.1124/jpet.116.237412_bib145
  article-title: ERbeta-selective SERMs produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks
  publication-title: Neurobiol Learn Mem
  doi: 10.1016/j.nlm.2005.10.003
– volume: 288
  start-page: 6438
  year: 2013
  ident: 10.1124/jpet.116.237412_bib3
  article-title: Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112.412478
– volume: 1209
  start-page: 115
  year: 2008
  ident: 10.1124/jpet.116.237412_bib198
  article-title: Aromatase distribution in the monkey temporal neocortex and hippocampus
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2008.02.061
– volume: 139
  start-page: 25
  year: 2014
  ident: 10.1124/jpet.116.237412_bib97
  article-title: Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic β-cell death
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2013.09.018
– volume: 64
  start-page: 251
  year: 2001
  ident: 10.1124/jpet.116.237412_bib131
  article-title: Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders
  publication-title: Prog Neurobiol
  doi: 10.1016/S0301-0082(00)00059-9
– volume: 58
  start-page: 812
  year: 2005
  ident: 10.1124/jpet.116.237412_bib137
  article-title: Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illness
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2005.04.047
– year: 2013
  ident: 10.1124/jpet.116.237412_bib6
– volume: 1007
  start-page: 54
  year: 2003
  ident: 10.1124/jpet.116.237412_bib132
  article-title: Estrogen receptor gene expression in relation to neuropsychiatric disorders
  publication-title: Ann N Y Acad Sci
  doi: 10.1196/annals.1286.006
– volume: 57
  start-page: 1519
  year: 2001
  ident: 10.1124/jpet.116.237412_bib96
  article-title: Estrogen, progesterone, and tic severity in women with Gilles de la Tourette syndrome
  publication-title: Neurology
  doi: 10.1212/WNL.57.8.1519
– volume: 35
  start-page: 2384
  year: 2015
  ident: 10.1124/jpet.116.237412_bib184
  article-title: G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1298-14.2015
– volume: 11
  start-page: 129
  year: 2013
  ident: 10.1124/jpet.116.237412_bib106
  article-title: The role of estrogen in the treatment of men with schizophrenia
  publication-title: Int J Endocrinol Metab
  doi: 10.5812/ijem.6615
– volume: 346
  start-page: 340
  year: 2002
  ident: 10.1124/jpet.116.237412_bib75
  article-title: Production and actions of estrogens
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra000471
– volume: 12
  start-page: 36
  year: 1986
  ident: 10.1124/jpet.116.237412_bib44
  article-title: Psychosis and pregnancy
  publication-title: Compr Ther
– volume: 36
  start-page: 272
  year: 2016
  ident: 10.1124/jpet.116.237412_bib177
  article-title: Tamoxifen: A Protein Kinase C Inhibitor to Treat Mania: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials
  publication-title: J Clin Psychopharmacol
  doi: 10.1097/JCP.0000000000000492
– volume: 106
  start-page: 1229
  year: 2000
  ident: 10.1124/jpet.116.237412_bib42
  article-title: Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α
  publication-title: J Clin Invest
  doi: 10.1172/JCI11066
– volume: 24
  start-page: 223
  year: 2014
  ident: 10.1124/jpet.116.237412_bib87
  article-title: Effects of raloxifene on cognition in postmenopausal women with schizophrenia: a double-blind, randomized, placebo-controlled trial
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2013.11.012
– volume: 30
  start-page: 13454
  year: 2010
  ident: 10.1124/jpet.116.237412_bib173
  article-title: Estrogen receptor ß activity modulates synaptic signaling and structure
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3264-10.2010
– volume: 32
  start-page: 1617
  year: 2008
  ident: 10.1124/jpet.116.237412_bib156
  article-title: Neurodevelopmental basis of bipolar disorder: a critical appraisal
  publication-title: Prog Neuropsychopharmacol Biol Psychiatry
  doi: 10.1016/j.pnpbp.2008.04.017
– volume: 26
  start-page: 495
  year: 2006
  ident: 10.1124/jpet.116.237412_bib150
  article-title: Improvement of sustained attention and visual and movement skills, but not clinical symptoms, after dehydroepiandrosterone augmentation in schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial
  publication-title: J Clin Psychopharmacol
  doi: 10.1097/01.jcp.0000237942.50270.35
– volume: 139
  start-page: 61
  year: 2009
  ident: 10.1124/jpet.116.237412_bib194
  article-title: Estrogen masculinizes neural pathways and sex-specific behaviors
  publication-title: Cell
  doi: 10.1016/j.cell.2009.07.036
– volume: 1
  start-page: 191
  year: 2007
  ident: 10.1124/jpet.116.237412_bib47
  article-title: The first-episode psychosis outcome study: Premorbid and baseline characteristics of an epidemiological cohort of 661 first-episode psychosis patients
  publication-title: Early Interv Psychiatry
  doi: 10.1111/j.1751-7893.2007.00026.x
– volume: 25
  start-page: 409
  year: 2002
  ident: 10.1124/jpet.116.237412_bib112
  article-title: Schizophrenia as a disorder of neurodevelopment
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev.neuro.25.112701.142754
– volume: 99
  start-page: 3996
  year: 2002
  ident: 10.1124/jpet.116.237412_bib147
  article-title: Disruption of estrogen receptor beta gene impairs spatial learning in female mice
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.012032699
– volume: 27
  start-page: 431
  year: 2002
  ident: 10.1124/jpet.116.237412_bib28
  article-title: Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/S0306-4530(01)00054-3
– volume: 1
  start-page: 81
  year: 1999
  ident: 10.1124/jpet.116.237412_bib77
  article-title: Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder
  publication-title: Bipolar Disord
  doi: 10.1034/j.1399-5618.1999.010204.x
– volume: 16
  start-page: 137
  year: 2006
  ident: 10.1124/jpet.116.237412_bib149
  article-title: Alterations in DHEA metabolism in schizophrenia: two-month case-control study
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2005.07.007
– volume: 16
  start-page: 464
  year: 2006
  ident: 10.1124/jpet.116.237412_bib141
  article-title: Inhibition of hippocampal estrogen synthesis causes region-specific downregulation of synaptic protein expression in hippocampal neurons
  publication-title: Hippocampus
  doi: 10.1002/hipo.20173
– volume: 9
  start-page: e1001081
  year: 2011
  ident: 10.1124/jpet.116.237412_bib17
  article-title: Why are autism spectrum conditions more prevalent in males?
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.1001081
– volume: 104
  start-page: 323
  year: 2001
  ident: 10.1124/jpet.116.237412_bib116
  article-title: Oestrogen withdrawal associated psychoses
  publication-title: Acta Psychiatr Scand
  doi: 10.1111/j.1600-0447.2001.00288.x
– volume: 60
  start-page: 1504
  year: 2008
  ident: 10.1124/jpet.116.237412_bib37
  article-title: Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer’s disease
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2008.06.003
– volume: 16
  start-page: 46
  year: 2005
  ident: 10.1124/jpet.116.237412_bib89
  article-title: Transcription factor cross-talk: the estrogen receptor and NF-kappaB
  publication-title: Trends Endocrinol Metab
  doi: 10.1016/j.tem.2005.01.004
– volume: 86
  start-page: 527
  year: 1994
  ident: 10.1124/jpet.116.237412_bib65
  article-title: Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/86.7.527
– volume: 141
  start-page: 3646
  year: 2000
  ident: 10.1124/jpet.116.237412_bib40
  article-title: Antiinflammatory effects of estrogen on microglial activation
  publication-title: Endocrinology
  doi: 10.1210/endo.141.10.7693
– volume: 81
  start-page: 294
  year: 2005
  ident: 10.1124/jpet.116.237412_bib206
  article-title: Effects of estrogen treatment on expression of brain-derived neurotrophic factor and cAMP response element-binding protein expression and phosphorylation in rat amygdaloid and hippocampal structures
  publication-title: Neuroendocrinology
  doi: 10.1159/000088448
– volume: 114
  start-page: 17
  year: 2009
  ident: 10.1124/jpet.116.237412_bib48
  article-title: Gender differences in premorbid, entry, treatment, and outcome characteristics in a treated epidemiological sample of 661 patients with first episode psychosis
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2009.07.002
– volume: 6
  start-page: 26
  year: 2014
  ident: 10.1124/jpet.116.237412_bib165
  article-title: Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI)
  publication-title: J Neurodev Disord
  doi: 10.1186/1866-1955-6-26
– volume: 17
  start-page: 2293
  year: 2008
  ident: 10.1124/jpet.116.237412_bib186
  article-title: Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddn130
– volume: 99
  start-page: 338
  year: 2008
  ident: 10.1124/jpet.116.237412_bib2
  article-title: Effect of raloxifene therapy on venous thromboembolism in postmenopausal women. A meta-analysis
  publication-title: Thromb Haemost
  doi: 10.1160/TH07-07-0468
– volume: 9
  start-page: 3415
  year: 2016
  ident: 10.1124/jpet.116.237412_bib86
  article-title: GPR30 decreases with vascular aging and promotes vascular smooth muscle cells maintaining differentiated phenotype and suppressing migration via activation of ERK1/2
  publication-title: Onco Targets Ther
– volume: 1621
  start-page: 147
  year: 2015
  ident: 10.1124/jpet.116.237412_bib80
  article-title: Estradiol rapidly modulates synaptic plasticity of hippocampal neurons: Involvement of kinase networks
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2014.12.056
– volume: 206
  start-page: 731
  year: 2009
  ident: 10.1124/jpet.116.237412_bib9
  article-title: Disruption of latent inhibition induced by ovariectomy can be reversed by estradiol and clozapine as well as by co-administration of haloperidol with estradiol but not by haloperidol alone
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-009-1464-0
– volume: 29
  start-page: 12982
  year: 2009
  ident: 10.1124/jpet.116.237412_bib98
  article-title: Cytoskeletal changes underlie estrogen’s acute effects on synaptic transmission and plasticity
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3059-09.2009
– volume: 191
  start-page: 139
  year: 2011
  ident: 10.1124/jpet.116.237412_bib15
  article-title: Estradiol synthesis within the human brain
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2011.02.012
– volume: 31
  start-page: 1508
  year: 2006
  ident: 10.1124/jpet.116.237412_bib69
  article-title: Raloxifene treatment enhances brain activation during recognition of familiar items: a pharmacological fMRI study in healthy elderly males
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1300956
– volume: 468
  start-page: 347
  year: 2004
  ident: 10.1124/jpet.116.237412_bib31
  article-title: Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression
  publication-title: J Comp Neurol
  doi: 10.1002/cne.10989
– volume: 36
  start-page: 1483
  year: 2016
  ident: 10.1124/jpet.116.237412_bib180
  article-title: Estradiol-mediated spine changes in the dorsal hippocampus and medial prefrontal cortex of ovariectomized female mice depend on ERK and mTOR activation in the dorsal hippocampus
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3135-15.2016
– volume: 28
  start-page: 8660
  year: 2008
  ident: 10.1124/jpet.116.237412_bib62
  article-title: Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1968-08.2008
– volume: 835
  start-page: 80
  year: 1999
  ident: 10.1124/jpet.116.237412_bib148
  article-title: Sex with knockout models: behavioral studies of estrogen receptor alpha
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(99)01452-3
– volume: 19
  start-page: 197
  year: 2013
  ident: 10.1124/jpet.116.237412_bib50
  article-title: Estrogen synthesis and signaling pathways during aging: from periphery to brain
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2012.12.007
– volume: 295
  start-page: 2465
  year: 2002
  ident: 10.1124/jpet.116.237412_bib163
  article-title: Molecular determinants for the tissue specificity of SERMs
  publication-title: Science
  doi: 10.1126/science.1068537
– volume: 230
  start-page: 134
  year: 2000
  ident: 10.1124/jpet.116.237412_bib21
  article-title: Oestrogen effects on dopaminergic function in striatum
  publication-title: Novartis Found Symp
  doi: 10.1002/0470870818.ch10
– volume: 1800
  start-page: 1121
  year: 2010
  ident: 10.1124/jpet.116.237412_bib202
  article-title: Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbagen.2010.06.002
– volume: 2
  start-page: 157
  year: 2009
  ident: 10.1124/jpet.116.237412_bib43
  article-title: Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome
  publication-title: Autism Res
  doi: 10.1002/aur.80
– volume: 98
  start-page: 12278
  year: 2001
  ident: 10.1124/jpet.116.237412_bib100
  article-title: Increased anxiety and synaptic plasticity in estrogen receptor beta -deficient mice
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.221451898
– volume: 77
  start-page: 60
  year: 2016
  ident: 10.1124/jpet.116.237412_bib203
  article-title: Estrogen modulation of calretinin and BDNF expression in midbrain dopaminergic neurons of ovariectomised mice
  publication-title: J Chem Neuroanat
  doi: 10.1016/j.jchemneu.2016.05.005
– volume: 204
  start-page: 105
  year: 2010
  ident: 10.1124/jpet.116.237412_bib115
  article-title: The unfolding stories of GPR30, a new membrane-bound estrogen receptor
  publication-title: J Endocrinol
  doi: 10.1677/JOE-09-0242
– volume: 105
  start-page: 14650
  year: 2008
  ident: 10.1124/jpet.116.237412_bib172
  article-title: Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0801581105
– volume: 4
  start-page: 43
  year: 2005
  ident: 10.1124/jpet.116.237412_bib7
  article-title: Effect of estrogen-serotonin interactions on mood and cognition
  publication-title: Behav Cogn Neurosci Rev
  doi: 10.1177/1534582305277152
– volume: 142
  start-page: 671
  year: 2015
  ident: 10.1124/jpet.116.237412_bib41
  article-title: Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort
  publication-title: Environ Res
  doi: 10.1016/j.envres.2015.07.024
– volume: 5
  start-page: 46
  year: 2014
  ident: 10.1124/jpet.116.237412_bib49
  article-title: Dysregulation of estrogen receptor beta (ERβ), aromatase (CYP19A1), and ER co-activators in the middle frontal gyrus of autism spectrum disorder subjects
  publication-title: Mol Autism
  doi: 10.1186/2040-2392-5-46
– volume: 26
  start-page: 595
  year: 2003
  ident: 10.1124/jpet.116.237412_bib10
  article-title: Gender differences in bipolar disorder
  publication-title: Psychiatr Clin North Am
  doi: 10.1016/S0193-953X(03)00036-4
– volume: 10
  start-page: 1286
  year: 1990
  ident: 10.1124/jpet.116.237412_bib72
  article-title: Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.10-04-01286.1990
– volume: 346
  start-page: 552
  year: 1995
  ident: 10.1124/jpet.116.237412_bib188
  article-title: From neuropathology to neurodevelopment
  publication-title: Lancet
  doi: 10.1016/S0140-6736(95)91386-6
– volume: 1036
  start-page: 101
  year: 2005
  ident: 10.1124/jpet.116.237412_bib66
  article-title: Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2004.12.014
– volume: 32
  start-page: 217
  year: 1997
  ident: 10.1124/jpet.116.237412_bib52
  article-title: Estrogen enhances performance of female rats during acquisition of a radial arm maze
  publication-title: Horm Behav
  doi: 10.1006/hbeh.1997.1433
– volume: 1204
  start-page: 104
  year: 2010
  ident: 10.1124/jpet.116.237412_bib58
  article-title: Estrogen and the aging brain: an elixir for the weary cortical network
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2010.05529.x
– volume: 77
  start-page: 618
  year: 2015
  ident: 10.1124/jpet.116.237412_bib199
  article-title: Increased coupling of caveolin-1 and estrogen receptor α contributes to the fragile X syndrome
  publication-title: Ann Neurol
  doi: 10.1002/ana.24358
– volume: 1052
  start-page: 57
  year: 2005
  ident: 10.1124/jpet.116.237412_bib36
  article-title: Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action
  publication-title: Ann N Y Acad Sci
  doi: 10.1196/annals.1347.005
– volume: 20
  start-page: 252
  year: 1997
  ident: 10.1124/jpet.116.237412_bib130
  article-title: NF-kappa B: a crucial transcription factor for glial and neuronal cell function
  publication-title: Trends Neurosci
  doi: 10.1016/S0166-2236(96)01035-1
– volume: 232
  start-page: 2981
  year: 2015
  ident: 10.1124/jpet.116.237412_bib109
  article-title: Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-015-3935-9
– volume: 159
  start-page: 1225
  year: 2002
  ident: 10.1124/jpet.116.237412_bib108
  article-title: Estrogen therapy and noncognitive psychiatric signs and symptoms in elderly patients with dementia
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.159.7.1225
– volume: 14
  start-page: 1979
  year: 2003
  ident: 10.1124/jpet.116.237412_bib117
  article-title: Impaired spatial reference memory in aromatase-deficient (ArKO) mice
  publication-title: Neuroreport
  doi: 10.1097/00001756-200310270-00020
– volume: 389
  start-page: 81
  year: 1997
  ident: 10.1124/jpet.116.237412_bib205
  article-title: Postnatal development and sex difference in neurons containing estrogen receptor-alpha immunoreactivity in the preoptic brain, the diencephalon, and the amygdala in the rat
  publication-title: J Comp Neurol
  doi: 10.1002/(SICI)1096-9861(19971208)389:1<81::AID-CNE6>3.0.CO;2-A
– volume: 22
  start-page: 2650
  year: 2002
  ident: 10.1124/jpet.116.237412_bib171
  article-title: Estrogen regulates the development of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.22-07-02650.2002
– volume: 49
  start-page: 28
  year: 2012
  ident: 10.1124/jpet.116.237412_bib152
  article-title: Biological evidence for a neurodevelopmental model of pediatric bipolar disorder
  publication-title: Isr J Psychiatry Relat Sci
– volume: 153
  start-page: 2953
  year: 2012
  ident: 10.1124/jpet.116.237412_bib64
  article-title: Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology
  publication-title: Endocrinology
  doi: 10.1210/en.2012-1061
– volume: 156
  start-page: 1941
  year: 2015
  ident: 10.1124/jpet.116.237412_bib160
  article-title: Elucidating the links between endocrine disruptors and neurodevelopment
  publication-title: Endocrinology
  doi: 10.1210/en.2014-1734
– volume: 164
  start-page: 635
  year: 2011
  ident: 10.1124/jpet.116.237412_bib11
  article-title: A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones
  publication-title: Eur J Endocrinol
  doi: 10.1530/EJE-10-1038
– volume: 33
  start-page: 1507
  year: 2012
  ident: 10.1124/jpet.116.237412_bib201
  article-title: Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2011.03.001
– volume: 153
  start-page: 2777
  year: 2012
  ident: 10.1124/jpet.116.237412_bib24
  article-title: A lack of ovarian function increases neuroinflammation in aged mice
  publication-title: Endocrinology
  doi: 10.1210/en.2011-1925
– volume: 5
  start-page: 620
  year: 2009
  ident: 10.1124/jpet.116.237412_bib168
  article-title: Estrogen therapy: is time of initiation critical for neuroprotection?
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/nrendo.2009.193
– volume: 64
  start-page: 2291
  year: 2004
  ident: 10.1124/jpet.116.237412_bib76
  article-title: Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management
  publication-title: Drugs
  doi: 10.2165/00003495-200464200-00003
– volume: 149
  start-page: 3176
  year: 2008
  ident: 10.1124/jpet.116.237412_bib68
  article-title: Sex-specific effects of gonadectomy and hormone treatment on acquisition of a 12-arm radial maze task by Sprague Dawley rats
  publication-title: Endocrinology
  doi: 10.1210/en.2007-1645
– volume: 150
  start-page: 662
  year: 1987
  ident: 10.1124/jpet.116.237412_bib90
  article-title: Epidemiology of puerperal psychoses
  publication-title: Br J Psychiatry
  doi: 10.1192/bjp.150.5.662
– volume: 97
  start-page: 3602
  year: 2000
  ident: 10.1124/jpet.116.237412_bib29
  article-title: The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.97.7.3602
– volume: 54
  start-page: 98
  year: 2008
  ident: 10.1124/jpet.116.237412_bib139
  article-title: Activational effects of estradiol and dihydrotestosterone on social recognition and the arginine-vasopressin immunoreactive system in male mice lacking a functional aromatase gene
  publication-title: Horm Behav
  doi: 10.1016/j.yhbeh.2008.02.001
– volume: 20
  start-page: 695
  year: 2015
  ident: 10.1124/jpet.116.237412_bib104
  article-title: Estradiol for treatment-resistant schizophrenia: a large-scale randomized-controlled trial in women of child-bearing age
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2014.33
– volume: 138
  start-page: 389
  year: 2006
  ident: 10.1124/jpet.116.237412_bib197
  article-title: Aromatase expression in the human temporal cortex
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2005.11.054
– volume: 57
  start-page: 777
  year: 2009
  ident: 10.1124/jpet.116.237412_bib19
  article-title: Treatment with selective estrogen receptor modulators regulates myelin specific T-cells and suppresses experimental autoimmune encephalomyelitis
  publication-title: Glia
  doi: 10.1002/glia.20805
– volume: 343
  start-page: 1318
  year: 1994
  ident: 10.1124/jpet.116.237412_bib91
  article-title: Effects of tamoxifen on uterus and ovaries of postmenopausal women in a randomised breast cancer prevention trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(94)92466-X
– volume: 56
  start-page: 757
  year: 2004
  ident: 10.1124/jpet.116.237412_bib53
  article-title: Language-association cortex asymmetry in autism and specific language impairment
  publication-title: Ann Neurol
  doi: 10.1002/ana.20275
– volume: 286
  start-page: 22441
  year: 2011
  ident: 10.1124/jpet.116.237412_bib45
  article-title: Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.224071
– volume: 19
  start-page: 588
  year: 2014
  ident: 10.1124/jpet.116.237412_bib185
  article-title: Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2013.83
– volume: 47
  start-page: 437
  year: 2002
  ident: 10.1124/jpet.116.237412_bib208
  article-title: The role of estrogen in schizophrenia: implications for schizophrenia practice guidelines for women
  publication-title: Can J Psychiatry
  doi: 10.1177/070674370204700504
– volume: 11
  start-page: 334
  year: 2008
  ident: 10.1124/jpet.116.237412_bib113
  article-title: Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory
  publication-title: Nat Neurosci
  doi: 10.1038/nn2057
– volume: 35
  start-page: 1259
  year: 2010
  ident: 10.1124/jpet.116.237412_bib190
  article-title: Fetal androgen exposure and pragmatic language ability of girls in middle childhood: implications for the extreme male-brain theory of autism
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2010.02.007
– volume: 67
  start-page: 505
  year: 2015
  ident: 10.1124/jpet.116.237412_bib142
  article-title: International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.114.009712
– volume: 52
  start-page: 352
  year: 2007
  ident: 10.1124/jpet.116.237412_bib67
  article-title: Estradiol enhances DMP acquisition via a mechanism not mediated by turning strategy but which requires intact basal forebrain cholinergic projections
  publication-title: Horm Behav
  doi: 10.1016/j.yhbeh.2007.05.011
– volume: 10
  start-page: 16
  year: 2016
  ident: 10.1124/jpet.116.237412_bib60
  article-title: Effect of tamoxifen and lithium on treatment of acute mania symptoms in children and adolescents
  publication-title: Iran J Child Neurol
– volume: 72
  start-page: 381
  year: 2007
  ident: 10.1124/jpet.116.237412_bib35
  article-title: Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications
  publication-title: Steroids
  doi: 10.1016/j.steroids.2007.02.003
– volume: 24
  start-page: 161
  year: 1999
  ident: 10.1124/jpet.116.237412_bib30
  article-title: Estradiol facilitates performance as working memory load increases
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/S0306-4530(98)00068-7
– volume: 111
  start-page: 77
  year: 2000
  ident: 10.1124/jpet.116.237412_bib55
  article-title: Female sex steroids: effects upon microglial cell activation
  publication-title: J Neuroimmunol
  doi: 10.1016/S0165-5728(00)00386-6
– volume: 27
  start-page: 1007
  year: 2003
  ident: 10.1124/jpet.116.237412_bib4
  article-title: Adjunctive estrogen treatment in women with chronic schizophrenia: a double-blind, randomized, and placebo-controlled trial
  publication-title: Prog Neuropsychopharmacol Biol Psychiatry
  doi: 10.1016/S0278-5846(03)00161-1
– volume: 32
  start-page: 1808
  year: 2011
  ident: 10.1124/jpet.116.237412_bib166
  article-title: A randomized controlled trial of estrogen treatment in men with mild cognitive impairment
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2009.11.002
– volume: 320
  start-page: 134
  year: 1986
  ident: 10.1124/jpet.116.237412_bib73
  article-title: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
  publication-title: Nature
  doi: 10.1038/320134a0
– volume: 40
  start-page: 2388
  year: 2015
  ident: 10.1124/jpet.116.237412_bib93
  article-title: Selective Estrogen Receptor Modulation Increases Hippocampal Activity during Probabilistic Association Learning in Schizophrenia
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2015.88
– volume: 21
  start-page: 1809
  year: 2001
  ident: 10.1124/jpet.116.237412_bib182
  article-title: Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-06-01809.2001
– volume: 100
  start-page: 1
  year: 2009
  ident: 10.1124/jpet.116.237412_bib13
  article-title: Fetal testosterone and autistic traits
  publication-title: Br J Psychol
  doi: 10.1348/000712608X311731
– volume: 168
  start-page: 652
  year: 2010
  ident: 10.1124/jpet.116.237412_bib123
  article-title: The influence of gonadal hormones on conditioned fear extinction in healthy humans
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.04.030
– volume: 73
  start-page: 947
  year: 2016
  ident: 10.1124/jpet.116.237412_bib103
  article-title: Effect of adjunctive raloxifene therapy on severity of refractory schizophrenia in women: a randomized clinical trial
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2016.1383
– volume: 112
  start-page: 239
  year: 2013
  ident: 10.1124/jpet.116.237412_bib118
  article-title: Neuroendocrine aspects of Tourette syndrome
  publication-title: Int Rev Neurobiol
  doi: 10.1016/B978-0-12-411546-0.00009-3
– volume: 180
  start-page: 155
  year: 1994
  ident: 10.1124/jpet.116.237412_bib195
  article-title: Quantitative microdialysis determination of extracellular striatal dopamine concentration in male and female rats: effects of estrous cycle and gonadectomy
  publication-title: Neurosci Lett
  doi: 10.1016/0304-3940(94)90510-X
– volume: 65
  start-page: 255
  year: 2008
  ident: 10.1124/jpet.116.237412_bib204
  article-title: Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archgenpsychiatry.2007.43
– volume: 120
  start-page: 1190
  year: 2012
  ident: 10.1124/jpet.116.237412_bib136
  article-title: Prenatal bisphenol a exposure and child behavior in an inner-city cohort
  publication-title: Environ Health Perspect
  doi: 10.1289/ehp.1104492
– volume: 60
  start-page: 288
  year: 2006
  ident: 10.1124/jpet.116.237412_bib82
  article-title: Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2005.10.019
– volume: 42
  start-page: 74
  year: 2008
  ident: 10.1124/jpet.116.237412_bib125
  article-title: Do women express and experience psychosis differently from men? Epidemiological evidence from the Australian National Study of Low Prevalence (Psychotic) Disorders
  publication-title: Aust N Z J Psychiatry
  doi: 10.1080/00048670701732699
– volume: 76
  start-page: 214
  year: 2002
  ident: 10.1124/jpet.116.237412_bib110
  article-title: Estrogenic properties of raloxifene, but not tamoxifen, on D2 and D3 dopamine receptors in the rat forebrain
  publication-title: Neuroendocrinology
  doi: 10.1159/000065951
– volume: 20
  start-page: 203
  year: 1994
  ident: 10.1124/jpet.116.237412_bib146
  article-title: Can estradiol modulate schizophrenic symptomatology?
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/20.1.203
– volume: 42
  start-page: 236
  year: 2011
  ident: 10.1124/jpet.116.237412_bib210
  article-title: Estrogen receptors stimulate brain region specific metabotropic glutamate receptors to rapidly initiate signal transduction pathways
  publication-title: J Chem Neuroanat
  doi: 10.1016/j.jchemneu.2011.02.002
– volume: 25
  start-page: 560
  year: 2013
  ident: 10.1124/jpet.116.237412_bib157
  article-title: Oestradiol modulation of serotonin reuptake transporter and serotonin metabolism in the brain of monkeys
  publication-title: J Neuroendocrinol
  doi: 10.1111/jne.12034
– volume: 16
  start-page: 199
  year: 1996
  ident: 10.1124/jpet.116.237412_bib34
  article-title: The modulation of brain dopamine and GABAA receptors by estradiol: a clue for CNS changes occurring at menopause
  publication-title: Cell Mol Neurobiol
  doi: 10.1007/BF02088176
– volume: 307
  start-page: 1625
  year: 2005
  ident: 10.1124/jpet.116.237412_bib144
  article-title: A transmembrane intracellular estrogen receptor mediates rapid cell signaling
  publication-title: Science
  doi: 10.1126/science.1106943
– volume: 644
  start-page: 305
  year: 1994
  ident: 10.1124/jpet.116.237412_bib170
  article-title: Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats
  publication-title: Brain Res
  doi: 10.1016/0006-8993(94)91694-2
– volume: 136
  start-page: 833
  year: 2005
  ident: 10.1124/jpet.116.237412_bib154
  article-title: Neurosteroid synthesis in the hippocampus: role in synaptic plasticity
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2005.03.056
– volume: 159
  start-page: 713
  year: 2002
  ident: 10.1124/jpet.116.237412_bib175
  article-title: Schizophrenia: reproductive hormones and the brain
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.159.5.713
– volume: 203
  start-page: 72
  year: 2007
  ident: 10.1124/jpet.116.237412_bib207
  article-title: Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2006.07.020
– volume: 122
  start-page: 754
  year: 2009
  ident: 10.1124/jpet.116.237412_bib18
  article-title: Raloxifene and risk for stroke based on the framingham stroke risk score
  publication-title: Am J Med
  doi: 10.1016/j.amjmed.2009.01.033
– volume: 53
  start-page: 169
  year: 2006
  ident: 10.1124/jpet.116.237412_bib95
  article-title: Estrogen, cognitive function and negative symptoms in female schizophrenia
  publication-title: Neuropsychobiology
  doi: 10.1159/000093780
– volume: 91
  start-page: 59
  year: 2004
  ident: 10.1124/jpet.116.237412_bib183
  article-title: Regulation of the lipopolysaccharide signal transduction pathway by 17beta-estradiol in macrophage cells
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2004.02.004
– volume: 45
  start-page: S116
  issue: 3, Suppl
  year: 2001
  ident: 10.1124/jpet.116.237412_bib127
  article-title: Estrogen production and action
  publication-title: J Am Acad Dermatol
  doi: 10.1067/mjd.2001.117432
– volume: 23
  start-page: 69
  year: 2000
  ident: 10.1124/jpet.116.237412_bib51
  article-title: Modulation by estrogen-receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain
  publication-title: Neuropsychopharmacology
  doi: 10.1016/S0893-133X(00)00085-3
– volume: 88
  start-page: 91
  year: 2008
  ident: 10.1124/jpet.116.237412_bib119
  article-title: Estradiol and the developing brain
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00010.2007
– volume: 7
  start-page: 136
  year: 2013
  ident: 10.1124/jpet.116.237412_bib5
  article-title: Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment
  publication-title: Front Behav Neurosci
  doi: 10.3389/fnbeh.2013.00136
– volume: 39
  start-page: 130
  year: 2013
  ident: 10.1124/jpet.116.237412_bib192
  article-title: Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbr070
– volume: 33
  start-page: 85
  year: 2012
  ident: 10.1124/jpet.116.237412_bib161
  article-title: Estrogen neuroprotection and the critical period hypothesis
  publication-title: Front Neuroendocrinol
  doi: 10.1016/j.yfrne.2011.10.001
– volume: 26
  start-page: 133
  year: 2010
  ident: 10.1124/jpet.116.237412_bib164
  article-title: Effects of synaptic plasticity regulated by 17beta-estradiol on learning and memory in rats with Alzheimer’s disease
  publication-title: Neurosci Bull
  doi: 10.1007/s12264-010-0913-4
– volume: 181
  start-page: 209
  year: 2010
  ident: 10.1124/jpet.116.237412_bib33
  article-title: The multiple roles of estrogens and the enzyme aromatase
  publication-title: Prog Brain Res
  doi: 10.1016/S0079-6123(08)81012-6
– volume: 151
  start-page: 4916
  year: 2010
  ident: 10.1124/jpet.116.237412_bib39
  article-title: Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta
  publication-title: Endocrinology
  doi: 10.1210/en.2010-0371
– volume: 1
  start-page: 133
  year: 2010
  ident: 10.1124/jpet.116.237412_bib128
  article-title: Functional interactions between steroid hormones and neurotrophin BDNF
  publication-title: World J Biol Chem
  doi: 10.4331/wjbc.v1.i5.133
– volume: 5
  start-page: e9851
  year: 2010
  ident: 10.1124/jpet.116.237412_bib200
  article-title: Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0009851
– volume: 3
  start-page: 17
  year: 2012
  ident: 10.1124/jpet.116.237412_bib12
  article-title: Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age
  publication-title: Mol Autism
  doi: 10.1186/2040-2392-3-17
– volume: 98
  start-page: 1952
  year: 2001
  ident: 10.1124/jpet.116.237412_bib56
  article-title: Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
  publication-title: Proc Natl Acad Sci USA
– volume: 47
  start-page: 562
  year: 2000
  ident: 10.1124/jpet.116.237412_bib27
  article-title: Steroid regulation of tryptophan hydroxylase protein in the dorsal raphe of macaques
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(99)00156-0
– volume: 93
  start-page: 5925
  year: 1996
  ident: 10.1124/jpet.116.237412_bib101
  article-title: Cloning of a novel receptor expressed in rat prostate and ovary
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.93.12.5925
– volume: 76
  start-page: 1243
  year: 1986
  ident: 10.1124/jpet.116.237412_bib129
  article-title: Triphenylethylenes: a new class of protein kinase C inhibitors
  publication-title: J Natl Cancer Inst
– volume: 22
  start-page: 115
  year: 2012
  ident: 10.1124/jpet.116.237412_bib124
  article-title: Polymorphisms in the maternal sex steroid pathway are associated with behavior problems in male offspring
  publication-title: Psychiatr Genet
  doi: 10.1097/YPG.0b013e328351850b
– volume: 73
  start-page: 1453
  year: 1999
  ident: 10.1124/jpet.116.237412_bib54
  article-title: Sodium salicylate and 17beta-estradiol attenuate nuclear transcription factor NF-kappaB translocation in cultured rat astroglial cultures following exposure to amyloid A beta(1-40) and lipopolysaccharides
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.1999.0731453.x
– volume: 34
  start-page: 1172
  year: 2008
  ident: 10.1124/jpet.116.237412_bib25
  article-title: Estrogen and comprehension of metaphoric speech in women suffering from schizophrenia: results of a double-blind, placebo-controlled trial
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbm138
– volume: 19
  start-page: 6385
  year: 1999
  ident: 10.1124/jpet.116.237412_bib57
  article-title: Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.19-15-06385.1999
– volume: 16
  start-page: 362
  year: 2005
  ident: 10.1124/jpet.116.237412_bib63
  article-title: GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
  publication-title: Trends Endocrinol Metab
  doi: 10.1016/j.tem.2005.08.005
– volume: 124
  start-page: 13
  year: 2010
  ident: 10.1124/jpet.116.237412_bib153
  article-title: Peripheral oxytocin is associated with reduced symptom severity in schizophrenia
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2010.09.014
– volume: 8
  start-page: 548
  year: 2015
  ident: 10.1124/jpet.116.237412_bib140
  article-title: Clozapine and risperidone influence on cortisol and estradiol levels in male patients with schizophrenia
  publication-title: J Med Life
– volume: 281
  start-page: 2189
  year: 1999
  ident: 10.1124/jpet.116.237412_bib209
  article-title: The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
  publication-title: JAMA
  doi: 10.1001/jama.281.23.2189
– volume: 158
  start-page: 1134
  year: 2001
  ident: 10.1124/jpet.116.237412_bib83
  article-title: Association of estrogen levels with neuropsychological performance in women with schizophrenia
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.158.7.1134
– volume: 26
  start-page: 48
  year: 2008
  ident: 10.1124/jpet.116.237412_bib111
  article-title: Raloxifene, a selective estrogen receptor modulator, inhibits lipopolysaccharide-induced nitric oxide production by inhibiting the phosphatidylinositol 3-kinase/Akt/nuclear factor-kappa B pathway in RAW264.7 macrophage cells
  publication-title: Mol Cells
  doi: 10.1016/S1016-8478(23)13962-8
– volume: 27
  start-page: 217
  year: 2006
  ident: 10.1124/jpet.116.237412_bib32
  article-title: New roles for estrogen receptor beta in behavior and neuroendocrinology
  publication-title: Front Neuroendocrinol
  doi: 10.1016/j.yfrne.2006.02.004
– volume: 3
  start-page: 433
  year: 2002
  ident: 10.1124/jpet.116.237412_bib23
  article-title: Oestrogen as a neuroprotective hormone
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn846
– volume: 164
  start-page: 887
  year: 2009
  ident: 10.1124/jpet.116.237412_bib122
  article-title: Estrous cycle phase and gonadal hormones influence conditioned fear extinction
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2009.09.011
– volume: 6
  start-page: 490
  year: 2005
  ident: 10.1124/jpet.116.237412_bib178
  article-title: One hundred years of hormones
  publication-title: EMBO Rep
  doi: 10.1038/sj.embor.7400444
– volume: 100
  start-page: 9614
  year: 2003
  ident: 10.1124/jpet.116.237412_bib181
  article-title: Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1531957100
– volume: 2015
  start-page: 615356
  year: 2015
  ident: 10.1124/jpet.116.237412_bib71
  article-title: A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
  publication-title: Int J Endocrinol
  doi: 10.1155/2015/615356
– volume: 6
  start-page: 7
  year: 2015
  ident: 10.1124/jpet.116.237412_bib85
  article-title: Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism
  publication-title: Mol Autism
  doi: 10.1186/2040-2392-6-7
– volume: 89
  start-page: 823
  year: 2001
  ident: 10.1124/jpet.116.237412_bib59
  article-title: Reciprocal antagonism between estrogen receptor and NF-kappaB activity in vivo
  publication-title: Circ Res
  doi: 10.1161/hh2101.098543
– volume: 30
  start-page: 67
  year: 2008
  ident: 10.1124/jpet.116.237412_bib120
  article-title: Schizophrenia: a concise overview of incidence, prevalence, and mortality
  publication-title: Epidemiol Rev
  doi: 10.1093/epirev/mxn001
– volume: 138
  start-page: 13
  year: 2015
  ident: 10.1124/jpet.116.237412_bib196
  article-title: Prenatal hyperandrogenic environment induced autistic-like behavior in rat offspring
  publication-title: Physiol Behav
  doi: 10.1016/j.physbeh.2014.09.014
– volume: 34
  start-page: 149
  year: 1998
  ident: 10.1124/jpet.116.237412_bib114
  article-title: Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters
  publication-title: Horm Behav
  doi: 10.1006/hbeh.1998.1473
– volume: 118
  start-page: 169
  year: 1990
  ident: 10.1124/jpet.116.237412_bib20
  article-title: Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis
  publication-title: Neurosci Lett
  doi: 10.1016/0304-3940(90)90618-J
– volume: 4
  start-page: 163
  year: 2011
  ident: 10.1124/jpet.116.237412_bib138
  article-title: Male predominance in autism: neuroendocrine influences on arousal and social anxiety
  publication-title: Autism Res
  doi: 10.1002/aur.191
– volume: 37
  start-page: 1427
  year: 2007
  ident: 10.1124/jpet.116.237412_bib26
  article-title: Estrogen, menstrual cycle phases, and psychopathology in women suffering from schizophrenia
  publication-title: Psychol Med
  doi: 10.1017/S0033291707000578
– volume: 20
  start-page: 685
  year: 2015
  ident: 10.1124/jpet.116.237412_bib187
  article-title: Adjunctive raloxifene treatment improves attention and memory in men and women with schizophrenia
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2015.11
– volume: 29
  start-page: 88
  year: 2008
  ident: 10.1124/jpet.116.237412_bib167
  article-title: Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review
  publication-title: Front Neuroendocrinol
  doi: 10.1016/j.yfrne.2007.08.002
– volume: 52
  start-page: 185
  year: 1997
  ident: 10.1124/jpet.116.237412_bib169
  article-title: Aromatase expression in health and disease
  publication-title: Recent Prog Horm Res
– volume: 29
  start-page: 241
  year: 2006
  ident: 10.1124/jpet.116.237412_bib16
  article-title: Is brain estradiol a hormone or a neurotransmitter?
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2006.03.004
– volume: 27
  start-page: 10832
  year: 2007
  ident: 10.1124/jpet.116.237412_bib8
  article-title: Estradiol improves cerebellar memory formation by activating estrogen receptor beta
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2588-07.2007
– volume: 18
  start-page: 547
  year: 2004
  ident: 10.1124/jpet.116.237412_bib46
  article-title: 17 β-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats
  publication-title: Fundam Clin Pharmacol
  doi: 10.1111/j.1472-8206.2004.00284.x
SSID ssj0014463
Score 2.4545634
SecondaryResourceType review_article
Snippet Estrogens, the primary female sex hormones, were originally characterized through their important role in sexual maturation and reproduction. However, recent...
SourceID pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 48
SubjectTerms Animals
Brain - drug effects
Brain - physiopathology
Estrogens - metabolism
Humans
Minireviews
Molecular Targeted Therapy - methods
Neurodevelopmental Disorders - drug therapy
Neurodevelopmental Disorders - pathology
Neurodevelopmental Disorders - physiopathology
Signal Transduction - drug effects
Title Estrogen Signaling as a Therapeutic Target in Neurodevelopmental Disorders
URI https://dx.doi.org/10.1124/jpet.116.237412
https://www.ncbi.nlm.nih.gov/pubmed/27789681
https://www.proquest.com/docview/1835691314
https://pubmed.ncbi.nlm.nih.gov/PMC5193073
Volume 360
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Li9swEBbp9tJL6bvpCxXKUsg6jSVZto8lpF0WtgTqhdyMH3JruuuEODm0P6u_sDOW7ChOA-1ejLHlSMk3lr5RZr4h5B1O-UJhqFSQZo4I3dABlp87niiUL0XhqgL3Oy6_yPMrcbHwFoPBbytqabtJx9mvv-aV3AZVuAa4YpbsfyDbfShcgHPAF46AMBz_CeNZvVkv4e7oa_kNCTXmG9ajBMMo2qSqUdSEeuO2RqPDke-ChJoJT2tv1jZH3WWLNTx1tRO31lpNe0UBrPytjp1P12VuimTfJJbLP8cKR6UOoyyvf2Bwt73p4Pq9TYdol_VS7YWXzvtDmtlDivpDshMKdMmIsTLzMMMOJ9yeqLmuPLBnkXra1WKdZgHXUvCHSwMTuDSALwLncsw4cClmtwRsVzeNpTDfD0KpS8n01Ljnl1PkvDAx3iF3oR3DxeDzogsrQveadwr18KWMnBT0_qHXN-pQm46OkaJDp6cfu2uRoegBuW-sg37UJvmQDFT1iJwaWH6eURuCM3pKbcAek4vWbmlntzSpaWI_RrXd0rKih3ZLO7t9Qq4-zaLpuWNqejiZEHzjpGHug48MfrBbeCG8zGk-kQHnXMrAZ6knVVBIpoBYplleSMVl4rEUFsHUT8B79vlTclItK_Wc0CzJQmDfUhYBUCwUwgwnIbD7DJz0iZyoIRm3P2qcGcF7rLtyHTeOLxMxAgJnMtaADMn77oGV1no53pS1KMWGqmoKGoO5HX_obYtnDJM4_jOXVGq5rWNYVz0ZutwVQ_JM49uNoLWRIfH3kO8aoED8_p2q_N4IxRtLfXHrJ1-Se7u3_xU52ay36jWQ8E36prH6P1u14hU
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Estrogen+Signaling+as+a+Therapeutic+Target+in+Neurodevelopmental+Disorders&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.au=Crider%2C+Amanda&rft.au=Pillai%2C+Anilkumar&rft.date=2017-01-01&rft.pub=The+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=0022-3565&rft.eissn=1521-0103&rft.volume=360&rft.issue=1&rft.spage=48&rft.epage=58&rft_id=info:doi/10.1124%2Fjpet.116.237412&rft_id=info%3Apmid%2F27789681&rft.externalDocID=PMC5193073
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3565&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3565&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3565&client=summon