Pathogen Sensing by Nucleotide-binding Oligomerization Domain-containing Protein 2 (NOD2) Is Mediated by Direct Binding to Muramyl Dipeptide and ATP

• Published in: The Journal of biological chemistry Vol. 287; no. 27; pp. 23057 - 23067
• Main Authors: Mo, Jinyao, Boyle, Joseph P., Howard, Christopher B., Monie, Tom P., Davis, Beckley K., Duncan, Joseph A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.06.2012; American Society for Biochemistry and Molecular Biology
• Subjects: Acetylmuramyl-Alanyl-Isoglutamine - metabolism; Adenosine Triphosphatases - metabolism; Adenosine Triphosphate; Adenosine Triphosphate - analogs & derivatives; Adenosine Triphosphate - metabolism; Animals; ATP; Bacterial Proteins - metabolism; Baculoviridae - genetics; Cells, Cultured; Cellular Immune Response; Chromatography, Affinity; HEK293 Cells; Humans; Immunity, Innate - physiology; Immunology; Inflammation; Innate Immunity; Insecta - cytology; Muramyl Dipeptide; Nod-like Receptors (NLR); Nod2 Signaling Adaptor Protein - genetics; Nod2 Signaling Adaptor Protein - immunology; Nod2 Signaling Adaptor Protein - metabolism; Nucleotide Binding and Oligomerization Domain-containing Protein 2; Pathogen-associated Molecular Pattern (PAMP); Protein Binding - physiology; Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism; Recombinant Proteins - genetics; Recombinant Proteins - immunology; Recombinant Proteins - metabolism; Signal Transduction; Signal Transduction - immunology; Signal Transduction; Nucleotide Binding and Oligomerization Domain-containing Protein 2; Innate Immunity; Pathogen-associated Molecular Pattern (PAMP); Inflammation; Nod-like Receptors (NLR); Cellular Immune Response; Adenosine Triphosphate; ATP; Muramyl Dipeptide

Nucleotide binding and oligomerization domain-containing protein 2 (NOD2/Card15) is an intracellular protein that is involved in the recognition of bacterial cell wall-derived muramyl dipeptide. Mutations in the gene encoding NOD2 are associated with inherited inflammatory disorders, including Crohn...