Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 43; pp. 26804 - 26811
• Main Authors: Leu, Julia I-Ju, Murphy, Maureen E., George, Donna L.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.10.2020
• Subjects: Activating Transcription Factor 4 - metabolism; Animals; Antioxidants; Biological Sciences; Cell Line; Coenzyme A; Coenzyme A - metabolism; Ferroptosis; Genes, p53; Genetic diversity; Genetic variance; Glucosephosphate dehydrogenase; Glutathione; Glutathione - metabolism; Glyceraldehyde-3-phosphate dehydrogenase; Glycolysis; Homeostasis; Humans; Low molecular weights; Male; Metabolism; Mice; Molecular weight; Oxidation; Oxidation-Reduction; Oxidative stress; p53 Protein; Pentose; Pentose phosphate pathway; Protein Processing, Post-Translational; Proteins; Redox reactions; Signal transduction; Signaling; Sulfhydryl Compounds - metabolism; Thiols; Transcription factors; Tumor suppressor genes; ferroptosis; cysteine modifications; ATF4; coenzyme A; p53

The p53 tumor suppressor protein is a transcription factor and master stress response mediator, and it is subject to reduction-oxidation (redox)-dependent regulation. The P47S variant of TP53, which exists primarily in African-descent populations, associates with an elevated abundance of low molecul...