Pseudomonas aeruginosa lasR mutant fitness in microoxia is supported by an Anr-regulated oxygen-binding hemerythrin

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 6; pp. 3167 - 3173
• Main Authors: Clay, Michelle E., Hammond, John H., Zhong, Fangfang, Chen, Xiaolei, Kowalski, Caitlin H., Lee, Alexandra J., Porter, Monique S., Hampton, Thomas H., Greene, Casey S., Pletneva, Ekaterina V., Hogan, Deborah A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.02.2020
• Subjects: Affinity; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biofilms; Biological Sciences; Cell Hypoxia - genetics; Clonal deletion; Cytochrome; Cytochrome-c oxidase; Cytochromes; Fitness; Genes; Genetic Fitness - genetics; Hemerythrin - genetics; Hemerythrin - metabolism; Lysogeny; Metabolism; Metabolomics; Mutants; Mutation; Oxygen; Oxygen - metabolism; Proteins; Pseudomonas aeruginosa; Pseudomonas aeruginosa - genetics; Pseudomonas aeruginosa - metabolism; Pseudomonas aeruginosa - physiology; Reproductive fitness; Sputum; Trans-Activators - genetics; Trans-Activators - metabolism; Transcription factors; microoxic growth; Pseudomonas aeruginosa; Anr; lasR; hemerythrin

Pseudomonas aeruginosa strains with loss-of-function mutations in the transcription factor LasR are frequently encountered in the clinic and the environment. Among the characteristics common to LasR-defective (LasR−) strains is increased activity of the transcription factor Anr, relative to their La...