Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesis

• Published in: Future oncology (London, England) Vol. 4; no. 6; pp. 793 - 802
• Main Authors: Lunt, Sarah Jane, Fyles, Anthony, Hill, Richard P, Milosevic, Michael
• Format: Journal Article
• Language: English
• Published: England Future Medicine 01.12.2008; Future Medicine Ltd
• Subjects: angiogenesis; Animals; biomarker; Biomarkers, Tumor - analysis; cancer; cervix cancer; chemotherapy; Extracellular Fluid; Humans; interstitial fluid pressure; Neoplasms - blood supply; Neoplasms - pathology; Neovascularization, Pathologic - pathology; Pressure; radiotherapy

Interstitial fluid pressure is elevated in virtually all solid malignant tumors as a result of abnormalities of the vasculature and interstitium. High interstitial fluid pressure is an independent predictor of disease recurrence in cervical cancer patients treated with radiotherapy, has been implica...