A translational study of circulating cell-free microRNA-1 in acute myocardial infarction
miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively stable due to binding with other materials. The aim of the present translational study is to establish a method of determin...
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| Published in | Clinical science (1979) Vol. 119; no. 2; pp. 87 - 95 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
20.04.2010
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| Subjects | |
| Online Access | Get full text |
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| Abstract | miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively stable due to binding with other materials. The aim of the present translational study is to establish a method of determining the absolute amount of an miRNA in blood and to determine the potential applications of circulating cell-free miR-1 (microRNA-1) in AMI (acute myocardial infarction). The results revealed that miR-1 is the most abundant miRNA in the heart and is also a heart- and muscle-specific miRNA. In a cardiac cell necrosis model induced by Triton X-100 in vitro, we found that cardiac miR-1 can be released into the culture medium and is stable at least for 24 h. In a rat model of AMI induced by coronary ligation, we found that serum miR-1 is quickly increased after AMI with a peak at 6 h, in which an increase in miR-1 of over 200-fold was demonstrated. The miR-1 level returned to basal levels at 3 days after AMI. Moreover, the serum miR-1 level in rats with AMI had a strong positive correlation with myocardial infarct size. To verify further the relationship between myocardial size and miR-1 level, an IP (ischaemic preconditioning) model was used. The results showed that IP significantly reduced circulating miR-1 levels and myocardial infract size induced by I/R (ischaemia/reperfusion) injury. Finally, the levels of circulating cell-free miR-1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB (creatine kinase-MB) levels. In conclusion, the results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI. |
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| AbstractList | miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively stable due to binding with other materials. The aim of the present translational study is to establish a method of determining the absolute amount of an miRNA in blood and to determine the potential applications of circulating cell-free miR-1 (microRNA-1) in AMI (acute myocardial infarction). The results revealed that miR-1 is the most abundant miRNA in the heart and is also a heart- and muscle-specific miRNA. In a cardiac cell necrosis model induced by Triton X-100 in vitro, we found that cardiac miR-1 can be released into the culture medium and is stable at least for 24 h. In a rat model of AMI induced by coronary ligation, we found that serum miR-1 is quickly increased after AMI with a peak at 6 h, in which an increase in miR-1 of over 200-fold was demonstrated. The miR-1 level returned to basal levels at 3 days after AMI. Moreover, the serum miR-1 level in rats with AMI had a strong positive correlation with myocardial infarct size. To verify further the relationship between myocardial size and miR-1 level, an IP (ischaemic preconditioning) model was used. The results showed that IP significantly reduced circulating miR-1 levels and myocardial infract size induced by I/R (ischaemia/reperfusion) injury. Finally, the levels of circulating cell-free miR-1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB (creatine kinase-MB) levels. In conclusion, the results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI.miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively stable due to binding with other materials. The aim of the present translational study is to establish a method of determining the absolute amount of an miRNA in blood and to determine the potential applications of circulating cell-free miR-1 (microRNA-1) in AMI (acute myocardial infarction). The results revealed that miR-1 is the most abundant miRNA in the heart and is also a heart- and muscle-specific miRNA. In a cardiac cell necrosis model induced by Triton X-100 in vitro, we found that cardiac miR-1 can be released into the culture medium and is stable at least for 24 h. In a rat model of AMI induced by coronary ligation, we found that serum miR-1 is quickly increased after AMI with a peak at 6 h, in which an increase in miR-1 of over 200-fold was demonstrated. The miR-1 level returned to basal levels at 3 days after AMI. Moreover, the serum miR-1 level in rats with AMI had a strong positive correlation with myocardial infarct size. To verify further the relationship between myocardial size and miR-1 level, an IP (ischaemic preconditioning) model was used. The results showed that IP significantly reduced circulating miR-1 levels and myocardial infract size induced by I/R (ischaemia/reperfusion) injury. Finally, the levels of circulating cell-free miR-1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB (creatine kinase-MB) levels. In conclusion, the results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI. miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively stable due to binding with other materials. The aim of the present translational study is to establish a method of determining the absolute amount of an miRNA in blood and to determine the potential applications of circulating cell-free miR-1 (microRNA-1) in AMI (acute myocardial infarction). The results revealed that miR-1 is the most abundant miRNA in the heart and is also a heart- and muscle-specific miRNA. In a cardiac cell necrosis model induced by Triton X-100 in vitro, we found that cardiac miR-1 can be released into the culture medium and is stable at least for 24 h. In a rat model of AMI induced by coronary ligation, we found that serum miR-1 is quickly increased after AMI with a peak at 6 h, in which an increase in miR-1 of over 200-fold was demonstrated. The miR-1 level returned to basal levels at 3 days after AMI. Moreover, the serum miR-1 level in rats with AMI had a strong positive correlation with myocardial infarct size. To verify further the relationship between myocardial size and miR-1 level, an IP (ischaemic preconditioning) model was used. The results showed that IP significantly reduced circulating miR-1 levels and myocardial infract size induced by I/R (ischaemia/reperfusion) injury. Finally, the levels of circulating cell-free miR-1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB (creatine kinase-MB) levels. In conclusion, the results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI. MicroRNAs (miRNAs) precipitate in many diseases including cardiovascular disease. In contrast to our original thought, miRNAs exist in circulating blood and they are relatively stable due to binding with other materials. The current translational study is to establish a method to determine the absolute amount of a miRNA in blood and to determine the potential applications of circulating cell-free microRNA-1 (miR-1) in acute myocardial infarction (AMI). The results revealed that miR-1 is the most abundant miRNA in the heart and is also a heart and muscle specific miRNA. In a cardiac cell necrosis model induced by Triton-100 in vitro , we found that cardiac miR-1 can be released into cultured medium and is stable at least for 24 h. In a rat model of AMI induced by coronary ligation, we found that serum miR-1 is quickly increased after AMI with the peak at 6h, in which an over 200-fold increased miR-1 was demonstrated. The miR-1 level was returned to basal level at 3 days after AMI. Moreover, the serum miR-1 level in rats with AMI has a strong positive correlation with the myocardial size. To further verify the relationship between myocardial size and miR-1 level, an ischemic preconditioning model was applied. The result showed that ischemic preconditioning significantly reduced the circulating miR-1 and the myocardial size induced by ischemia-reperfusion injury. Finally, the levels of circulating cell-free miR-1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB levels. The results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI. miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively stable due to binding with other materials. The aim of the present translational study is to establish a method of determining the absolute amount of an miRNA in blood and to determine the potential applications of circulating cell-free miR-1 (microRNA-1) in AMI (acute myocardial infarction). The results revealed that miR-1 is the most abundant miRNA in the heart and is also a heart- and muscle-specific miRNA. In a cardiac cell necrosis model induced by Triton X-100 in vitro, we found that cardiac miR-1 can be released into the culture medium and is stable at least for 24 h. In a rat model of AMI induced by coronary ligation, we found that serum miR-1 is quickly increased after AMI with a peak at 6 h, in which an increase in miR-1 of over 200-fold was demonstrated. The miR-1 level returned to basal levels at 3 days after AMI. Moreover, the serum miR-1 level in rats with AMI had a strong positive correlation with myocardial infarct size. To verify further the relationship between myocardial size and miR-1 level, an IP (ischaemic preconditioning) model was used. The results showed that IP significantly reduced circulating miR-1 levels and myocardial infract size induced by I/R (ischaemia/reperfusion) injury. Finally, the levels of circulating cell-free miR-1 were significantly increased in patients with AMI and had a positive correlation with serum CK-MB (creatine kinase-MB) levels. In conclusion, the results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI. |
| Author | He, Pengcheng Cheng, Yunhui Cao, Xiaopei Yang, Jian Liu, Xiaojun Tan, Ning Qin, Shanshan Zhang, Chunxiang Dong, Xiaoli |
| AuthorAffiliation | 4 Sino-American Institute for Translational Medicine, The affiliated hospital of Luzhou Medical College, Luzhou, 646000. China 3 Department of Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China 1 RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA 2 Department of Cardiology, Guangdong Cardiovascular Institute & Guangdong Provincial People's Hospital, Guangzhou, 510100, China |
| AuthorAffiliation_xml | – name: 1 RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA – name: 3 Department of Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China – name: 2 Department of Cardiology, Guangdong Cardiovascular Institute & Guangdong Provincial People's Hospital, Guangzhou, 510100, China – name: 4 Sino-American Institute for Translational Medicine, The affiliated hospital of Luzhou Medical College, Luzhou, 646000. China |
| Author_xml | – sequence: 1 givenname: Yunhui surname: Cheng fullname: Cheng, Yunhui organization: RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, U.S.A – sequence: 2 givenname: Ning surname: Tan fullname: Tan, Ning organization: RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, U.S.A., Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academic of Medical Sciences, Guangzhou 510100, China – sequence: 3 givenname: Jian surname: Yang fullname: Yang, Jian organization: RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, U.S.A – sequence: 4 givenname: Xiaojun surname: Liu fullname: Liu, Xiaojun organization: RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, U.S.A – sequence: 5 givenname: Xiaopei surname: Cao fullname: Cao, Xiaopei organization: Department of Endocrinology, First Affiliated Hospital, Sun yat-sen University, Guangzhou, 510080, China – sequence: 6 givenname: Pengcheng surname: He fullname: He, Pengcheng organization: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academic of Medical Sciences, Guangzhou 510100, China – sequence: 7 givenname: Xiaoli surname: Dong fullname: Dong, Xiaoli organization: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academic of Medical Sciences, Guangzhou 510100, China – sequence: 8 givenname: Shanshan surname: Qin fullname: Qin, Shanshan organization: Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academic of Medical Sciences, Guangzhou 510100, China – sequence: 9 givenname: Chunxiang surname: Zhang fullname: Zhang, Chunxiang organization: RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, U.S.A., Sino-American Institute for Translational Medicine, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20218970$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1126/science.3941911 10.2353/ajpath.2007.061170 10.1016/j.yjmcc.2009.01.008 10.1590/S0074-02762004000700006 10.1016/0092-8674(93)90529-Y 10.1373/clinchem.2009.125310 10.1016/0092-8674(93)90530-4 10.1038/ng1590 10.1074/jbc.M109.027896 10.1038/cr.2008.290 10.1042/CS20070211 10.1101/gad.1356105 10.1016/j.cell.2004.12.035 10.1073/pnas.0804549105 10.1016/S0960-9822(02)00809-6 10.1073/pnas.0813371106 10.1159/000268088 10.1016/j.bbrc.2009.02.097 10.1146/annurev.med.59.053006.104707 10.1517/14712590902932889 10.1161/CIRCRESAHA.106.141986 10.1186/1756-0500-2-89 10.1093/eurheartj/ehq013 10.1074/jbc.M801035200 10.1161/CIRCRESAHA.109.197517 10.1128/MCB.01222-08 10.1038/nature03817 10.1016/j.bbrc.2009.11.005 10.1161/CIRCRESAHA.109.200451 10.1126/science.1064921 10.1016/S1672-0229(05)03011-1 10.1074/jbc.M806920200 10.1038/ncb1596 10.1038/nrg1990 10.1152/physiolgenomics.00034.2008 10.1016/j.cell.2007.04.040 |
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| References | Chin (2021113010131991500_B25) 2008; 18 Zaug (2021113010131991500_B1a) 1986; 231 Cheng (2021113010131991500_B18) 2009; 47 Sokol (2021113010131991500_B33) 2005; 19 Ji (2021113010131991500_B34) 2009; 55 Lagos-Quintana (2021113010131991500_B11) 2002; 12 Valadi (2021113010131991500_B24) 2007; 9 Wang (2021113010131991500_B27) 2009; 106 Shan (2021113010131991500_B30) 2009; 381 Kong (2021113010131991500_B2) 2005; 3 Wightman (2021113010131991500_B4) 1993; 75 Chua (2021113010131991500_B1) 2009; 11 Landgraf (2021113010131991500_B20) 2007; 129 Garzon (2021113010131991500_B23) 2009; 60 Luo (2021113010131991500_B28) 2008; 283 Zhao (2021113010131991500_B21) 2005; 436 Dong. (2021113010131991500_B14) 2009; 284 Wang (2021113010131991500_B36) 2010; 31 Lee (2021113010131991500_B3) 1993; 75 Chen (2021113010131991500_B7) 2007; 8 Bentwich (2021113010131991500_B6) 2005; 37 Cortez (2021113010131991500_B13) 2009; 9 Lin (2021113010131991500_B17) 2009; 284 Bostjancic (2021113010131991500_B31) 2009; 115 Zhang (2021113010131991500_B9) 2008; 114 Cheng (2021113010131991500_B12) 2009; 105 Zhang (2021113010131991500_B10) 2008; 33 Zhu (2021113010131991500_B26) 2009; 2 Mitchell (2021113010131991500_B32) 2008; 105 Lagos-Quintana (2021113010131991500_B5) 2001; 294 Souza (2021113010131991500_B19) 2004; 299 Ji (2021113010131991500_B15) 2007; 100 Cheng (2021113010131991500_B16) 2007; 170 Ikeda (2021113010131991500_B29) 2009; 29 Lewis (2021113010131991500_B8) 2005; 120 Rao (2021113010131991500_B22) 2009; 105 Ai (2021113010131991500_B35) 2010; 391 |
| References_xml | – volume: 231 start-page: 470 year: 1986 ident: 2021113010131991500_B1a article-title: The intervening sequence RNA of Tetrahymena is an enzyme publication-title: Science doi: 10.1126/science.3941911 – volume: 170 start-page: 1831 year: 2007 ident: 2021113010131991500_B16 article-title: MiroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2007.061170 – volume: 47 start-page: 5 year: 2009 ident: 2021113010131991500_B18 article-title: MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4 publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2009.01.008 – volume: 299 start-page: 697 year: 2004 ident: 2021113010131991500_B19 article-title: In vitro measurement of enzymatic markers as a tool to detect mouse cardiomyocytes injury publication-title: Mem. Inst. Oswaldo Cruz doi: 10.1590/S0074-02762004000700006 – volume: 75 start-page: 843 year: 1993 ident: 2021113010131991500_B3 article-title: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 publication-title: Cell doi: 10.1016/0092-8674(93)90529-Y – volume: 55 start-page: 1944 year: 2009 ident: 2021113010131991500_B34 article-title: Plasma miR-208 as a biomarker of myocardial injury publication-title: Clin. Chem. doi: 10.1373/clinchem.2009.125310 – volume: 75 start-page: 855 year: 1993 ident: 2021113010131991500_B4 article-title: Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans publication-title: Cell doi: 10.1016/0092-8674(93)90530-4 – volume: 37 start-page: 766 year: 2005 ident: 2021113010131991500_B6 article-title: Identification of hundreds of conserved and nonconserved human microRNAs publication-title: Nat. Genet. doi: 10.1038/ng1590 – volume: 284 start-page: 29514 year: 2009 ident: 2021113010131991500_B14 article-title: MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.027896 – volume: 18 start-page: 983 year: 2008 ident: 2021113010131991500_B25 article-title: A truth serum for cancer: microRNAs have major potential as cancer biomarkers publication-title: Cell Res. doi: 10.1038/cr.2008.290 – volume: 114 start-page: 699 year: 2008 ident: 2021113010131991500_B9 article-title: MicroRNAs: role in cardiovascular biology and disease publication-title: Clin. Sci. doi: 10.1042/CS20070211 – volume: 19 start-page: 2343 year: 2005 ident: 2021113010131991500_B33 article-title: Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth publication-title: Genes Dev. doi: 10.1101/gad.1356105 – volume: 120 start-page: 15 year: 2005 ident: 2021113010131991500_B8 article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets publication-title: Cell doi: 10.1016/j.cell.2004.12.035 – volume: 105 start-page: 10513 year: 2008 ident: 2021113010131991500_B32 article-title: Circulating microRNAs as stable blood-based markers for cancer detection publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0804549105 – volume: 12 start-page: 735 year: 2002 ident: 2021113010131991500_B11 article-title: Identification of tissue-specific microRNAs from mouse publication-title: Curr. Biol. doi: 10.1016/S0960-9822(02)00809-6 – volume: 106 start-page: 4402 year: 2009 ident: 2021113010131991500_B27 article-title: Circulating microRNAs, potential biomarkers for drug-induced liver injury publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0813371106 – volume: 115 start-page: 163 year: 2009 ident: 2021113010131991500_B31 article-title: MicroRNAs miR-1, miR-133a, miR-133b and miR-208 are dysregulated in human myocardial infarction publication-title: Cardiology doi: 10.1159/000268088 – volume: 381 start-page: 597 year: 2009 ident: 2021113010131991500_B30 article-title: Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2009.02.097 – volume: 60 start-page: 167 year: 2009 ident: 2021113010131991500_B23 article-title: MicroRNAs in cancer publication-title: Annu. Rev. Med. doi: 10.1146/annurev.med.59.053006.104707 – volume: 9 start-page: 703 year: 2009 ident: 2021113010131991500_B13 article-title: MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases publication-title: Expert Opin. Biol. Ther. doi: 10.1517/14712590902932889 – volume: 100 start-page: 1579 year: 2007 ident: 2021113010131991500_B15 article-title: MicroRNA expression signature and antisense-mediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.106.141986 – volume: 2 start-page: 89 year: 2009 ident: 2021113010131991500_B26 article-title: Circulating microRNAs in breast cancer and healthy subjects publication-title: BMC Res. Notes doi: 10.1186/1756-0500-2-89 – volume: 31 start-page: 656 year: 2010 ident: 2021113010131991500_B36 article-title: Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehq013 – volume: 11 start-page: 189 year: 2009 ident: 2021113010131991500_B1 article-title: MicroRNAs: biogenesis, function and applications publication-title: Curr. Opin. Mol. Ther. – volume: 283 start-page: 2045 year: 2008 ident: 2021113010131991500_B28 article-title: Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart publication-title: J. Biol. Chem. doi: 10.1074/jbc.M801035200 – volume: 105 start-page: 158 year: 2009 ident: 2021113010131991500_B12 article-title: MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.109.197517 – volume: 29 start-page: 2193 year: 2009 ident: 2021113010131991500_B29 article-title: MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01222-08 – volume: 436 start-page: 214 year: 2005 ident: 2021113010131991500_B21 article-title: Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis publication-title: Nature doi: 10.1038/nature03817 – volume: 391 start-page: 73 year: 2010 ident: 2021113010131991500_B35 article-title: Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2009.11.005 – volume: 105 start-page: 585 year: 2009 ident: 2021113010131991500_B22 article-title: Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.109.200451 – volume: 294 start-page: 853 year: 2001 ident: 2021113010131991500_B5 article-title: Identification of novel genes coding for small expressed RNAs publication-title: Science doi: 10.1126/science.1064921 – volume: 3 start-page: 62 year: 2005 ident: 2021113010131991500_B2 article-title: MicroRNA: biological and computational perspective publication-title: Genomics Proteomics Bioinformatics doi: 10.1016/S1672-0229(05)03011-1 – volume: 284 start-page: 7903 year: 2009 ident: 2021113010131991500_B17 article-title: Involvement of microRNAs in hydrogen peroxidemediated gene regulation and cellular injury response in vascular smooth muscle cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M806920200 – volume: 9 start-page: 654 year: 2007 ident: 2021113010131991500_B24 article-title: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells publication-title: Nat. Cell Biol. doi: 10.1038/ncb1596 – volume: 8 start-page: 93 year: 2007 ident: 2021113010131991500_B7 article-title: The evolution of gene regulation by transcription factors and microRNAs publication-title: Nat. Rev. Genet. doi: 10.1038/nrg1990 – volume: 33 start-page: 139 year: 2008 ident: 2021113010131991500_B10 article-title: MicroRNomics: a newly emerging approach for disease publication-title: Physiol. Genomics doi: 10.1152/physiolgenomics.00034.2008 – volume: 129 start-page: 1401 year: 2007 ident: 2021113010131991500_B20 article-title: A mammalian microRNA expression atlas based on small RNA library sequencing publication-title: Cell doi: 10.1016/j.cell.2007.04.040 |
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| Snippet | miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood... MicroRNAs (miRNAs) precipitate in many diseases including cardiovascular disease. In contrast to our original thought, miRNAs exist in circulating blood and... |
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| SubjectTerms | Aged Animals Biomarkers - blood Cells, Cultured Female Humans Ischemic Preconditioning, Myocardial Male MicroRNAs - blood MicroRNAs - metabolism Middle Aged Myocardial Infarction - blood Myocardial Infarction - etiology Myocardial Infarction - pathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - complications Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Necrosis Rats Rats, Sprague-Dawley |
| Title | A translational study of circulating cell-free microRNA-1 in acute myocardial infarction |
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