Three-component addition of terminal alkynes, carboxylic acids, and tert-butyl hypochlorite

• Published in: Chemical Communications Vol. 58; no. 16; pp. 2670 - 2673
• Main Authors: Zhang, Xitao, Zhang, Sheng, Li, Shihong, Feng, Xiujuan, Yamamoto, Yoshinori, Bao, Ming
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Society of Chemistry (RSC) 22.02.2022; Royal Soc Chemistry; Royal Society of Chemistry
• Subjects: Alkynes; Carboxylic acids; chemical communication; Chemistry; Chemistry, Multidisciplinary; Functional groups; hypochlorites; Nitrogen dioxide; Physical Sciences; Science & Technology; FUNCTIONALIZATION; ALKENES; CATALYZED ADDITION; HYDROAMINATION; ANTI-MARKOVNIKOV ADDITION

This paper described the unprecedented three-component addition of terminal alkynes, carboxylic acids, and tert -butyl hypochlorite. This new type of addition proceeds smoothly to produce gem -dichloroalkane derivatives in satisfactory to excellent yields via successive two-time additions under mild...