Three-component addition of terminal alkynes, carboxylic acids, and tert-butyl hypochlorite

This paper described the unprecedented three-component addition of terminal alkynes, carboxylic acids, and tert -butyl hypochlorite. This new type of addition proceeds smoothly to produce gem -dichloroalkane derivatives in satisfactory to excellent yields via successive two-time additions under mild...

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Bibliographic Details
Published inChemical Communications Vol. 58; no. 16; pp. 2670 - 2673
Main Authors Zhang, Xitao, Zhang, Sheng, Li, Shihong, Feng, Xiujuan, Yamamoto, Yoshinori, Bao, Ming
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Society of Chemistry (RSC) 22.02.2022
Royal Soc Chemistry
Royal Society of Chemistry
Subjects
Alkynes
Carboxylic acids
chemical communication
Chemistry
Chemistry, Multidisciplinary
Functional groups
hypochlorites
Nitrogen dioxide
Physical Sciences
Science & Technology
FUNCTIONALIZATION
ALKENES
CATALYZED ADDITION
HYDROAMINATION
ANTI-MARKOVNIKOV ADDITION
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Summary:This paper described the unprecedented three-component addition of terminal alkynes, carboxylic acids, and tert -butyl hypochlorite. This new type of addition proceeds smoothly to produce gem -dichloroalkane derivatives in satisfactory to excellent yields via successive two-time additions under mild conditions. The synthetically useful functional groups, such as Cl, Br, CN, and NO 2 , remained intact in the final products.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d2cc00374k