Epstein–Barr virus EBER1 and murine gammaherpesvirus TMER4 share conserved in vivo function to promote B cell egress and dissemination

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 51; pp. 25392 - 25394
• Main Authors: Hoffman, Brett A., Wang, Yiping, Feldman, Emily R., Tibbetts, Scott A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 17.12.2019
• Series: Brief Report
• Subjects: Animals; Biological Sciences; BRIEF REPORTS; Cells, Cultured; Egress; Epstein-Barr virus; Gammaherpesvirinae - genetics; Herpesviridae Infections - virology; In vivo methods and tests; Kaposi's sarcoma; Latency; Lymph nodes; Lymphocytes B; Mice; Nucleic Acid Conformation; Peripheral circulation; Ribonucleic acid; RNA; RNA, Untranslated - chemistry; RNA, Untranslated - genetics; RNA, Untranslated - physiology; RNA, Viral - chemistry; RNA, Viral - genetics; RNA, Viral - physiology; Sarcoma; Spleen - cytology; Spleen - virology; Tumorigenesis; Virus Latency - genetics; Virus Release - genetics; Viruses; murine; EBV; EBER; noncoding RNA; herpesvirus

The oncogenic gammaherpesviruses, including human Epstein–Barr virus (EBV), human Kaposi’s sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV68, γHV68, MuHV-4) establish life-long latency in circulating B cells. The precise determinants that mediate in vivo gammaherpesvirus l...