Anti-CD20 therapy depletes activated myelin-specific CD8⁺ T cells in multiple sclerosis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 51; pp. 25800 - 25807
• Main Authors: Sabatino, Joseph J., Wilson, Michael R., Calabresi, Peter A., Hauser, Stephen L., Schneck, Jonathan P., Zamvil, Scott S.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 17.12.2019
• Series: From the Cover
• Subjects: Adolescent; Adult; Antibodies, Monoclonal - metabolism; Antigens, CD20 - immunology; Antigens, CD20 - metabolism; Biological Sciences; CD20 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - metabolism; Cells, Cultured; Epitopes; Female; Histocompatibility antigen HLA; Humans; Immunological memory; Immunotherapy; Influenza; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Male; Memory cells; Middle Aged; Monoclonal antibodies; Multiple sclerosis; Multiple Sclerosis - immunology; Multiple Sclerosis - metabolism; Myelin; Myelin Proteins - metabolism; Pathogenesis; Peripheral blood; Phenotypes; Precursors; Therapy; Young Adult; CD8+ T cells; anti-CD20 therapy; multiple sclerosis; myelin antigen

CD8⁺ T cells are believed to play an important role in multiple sclerosis (MS), yet their role in MS pathogenesis remains poorly defined. Although myelin proteins are considered potential autoantigenic targets, prior studies of myelin-reactive CD8⁺ T cells in MS have relied on in vitro stimulation,...