Control of resistance against bacteriophage killing by a metabolic regulator in meningitis-associated Escherichia coli

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 45; pp. 1 - 9
• Main Authors: Connolly, James P. R., Turner, Natasha C. A., Serrano, Ester, Rimbi, Patricia T., Browning, Douglas F., O’Boyle, Nicky, Roe, Andrew J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 08.11.2022
• Subjects: Acetylation; Bacteriophages - metabolism; Binding sites; Biological Sciences; Catabolism; Cell surface; Chromosomes; Coliforms; D-Serine; E coli; Endothelial cells; Endothelial Cells - metabolism; Escherichia coli; Escherichia coli - metabolism; Escherichia coli Proteins - metabolism; Gene sequencing; Genomes; Humans; Infant, Newborn; Meningitis; Neonates; Neural coding; Operons; Phages; Serine - metabolism; Transcription factors; transcription factor; capsule; regulation; bacteriophage; E. coli

Ecologically beneficial traits in bacteria are encoded by intrinsic and horizontally acquired genes. However, such traits are not universal, and the highly mosaic nature of bacterial genomes requires control at the transcriptional level to drive these processes. It has emerged that regulatory flexib...