FGFR3 mutations in prostate cancer: association with low-grade tumors

• Published in: Modern pathology Vol. 22; no. 6; pp. 848 - 856
• Main Authors: Hernández, Silvia, de Muga, Silvia, Agell, Laia, Juanpere, Nuria, Esgueva, Raquel, Lorente, José A, Mojal, Sergi, Serrano, Sergio, Lloreta, Josep
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.06.2009; Elsevier Limited
• Subjects: Autopsies; Biopsy; Bladder cancer; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Colorectal cancer; DNA Mutational Analysis; Humans; Kinases; Laboratory Medicine; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Medicine; Medicine & Public Health; Metastasis; Mutation; Neoplasms, Multiple Primary - genetics; Neoplasms, Multiple Primary - pathology; original-article; Pathology; Patients; Polymerase Chain Reaction; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Receptor, Fibroblast Growth Factor, Type 3 - genetics; Skin Neoplasms - genetics; Skin Neoplasms - pathology; Tumors; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology; Spain; mutation; skin tumors; prostate cancer; bladder cancer

Prostate cancer is the second cause of cancer-related death in men of the Western World. The role of FGFR3 and its abnormalities in prostate cancer are not known. FGFR3 mutations have been reported in some human tumors. Few studies have analyzed the mutations of FGFR3 in prostate tumors, and no muta...